Todos os posts

Estudo randomizado | Em pacientes com dor neuropática diabética, a amitriptilina suplementada com pregabalina, a pregabalina suplementada com amitriptilina e a duloxetina suplementada com pregabalina foram similarmente efetivas.

29 Ago, 2022 | 17:24h

Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial – The Lancet

 

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Estudo randomizado | Em pacientes com carcinoma nasofaríngeo de baixo risco, a radioterapia isolada foi não inferior à radioterapia com quimioterapia concomitante em relação à sobrevida sem recorrência da doença em 3 anos.

29 Ago, 2022 | 17:22h

Effect of Radiotherapy Alone vs Radiotherapy With Concurrent Chemoradiotherapy on Survival Without Disease Relapse in Patients With Low-risk Nasopharyngeal Carcinoma: A Randomized Clinical Trial – JAMA (gratuito por tempo limitado)

Nota do editor em vídeo: Radiotherapy With vs Without Chemoradiotherapy in Low-risk Nasopharyngeal Carcinoma – JAMA

 

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Estudo randomizado | Enoxaparina (40 mg/dia) é superior à aspirina (100 mg/dia) para prevenção de tromboembolismo em pacientes submetidos a artroplastia de quadril ou joelho.

29 Ago, 2022 | 17:20h

Effect of Aspirin vs Enoxaparin on Symptomatic Venous Thromboembolism in Patients Undergoing Hip or Knee Arthroplasty: The CRISTAL Randomized Trial – JAMA (gratuito por tempo limitado)

Editorial: Thromboprophylaxis After Hip or Knee Arthroplasty – JAMA

 

Comentário no Twitter

In patients undergoing hip or knee arthroplasty for osteoarthritis, aspirin compared with enoxaparin resulted in a significantly higher rate of symptomatic venous thromboembolism (VTE), including below-knee VTE. #Research https://t.co/CdlbAgBttJ

— JAMA (@JAMA_current) August 23, 2022

 

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Estudo randomizado | Em pacientes com transtorno de uso de álcool, a porcentagem de dias de alto consumo foi reduzida com o uso de substância psicodélica.

29 Ago, 2022 | 17:19h

Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder: A Randomized Clinical Trial – JAMA Psychiatry

Comunicado de imprensa: Psychedelic drug therapy may help treat alcohol addiction – NYU Grossman School of Medicine

 

Comentário no Twitter:

In adults with alcohol-dependence, two doses of #psilocybin in combination with psychotherapy produced robust decreases in drinking relative to the outcomes observed with placebo and psychotherapy. https://t.co/M8PCbfwmWn #Research pic.twitter.com/duCJUL0jhx

— JAMA Psychiatry (@JAMAPsych) August 24, 2022

 

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Editorial | Mantendo as metanálises atuais.

29 Ago, 2022 | 17:17h

Keeping Meta-analyses Fresh – JAMA Network Open

 

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Estudo de coorte retrospectiva | Uso de nirmatrelvir e desfechos de Covid-19 grave durante o aumento da variante Ômicron.

29 Ago, 2022 | 17:16h

Nirmatrelvir Use and Severe Covid-19 Outcomes during the Omicron Surge – New England Journal of Medicine

 

Comentário no Twitter

During the clinical rollout of nirmatrelvir in Israel in early 2022, most patients (78%) had previous SARS-CoV-2 immunity. Benefit was seen among patients at highest risk for Covid-19 progression, such as those 65+. https://t.co/O6CxzDdIfH pic.twitter.com/ccCaCCh15i

— NEJM (@NEJM) August 24, 2022

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Hospitalizações por envenenamento não intencional por Cannabis entre crianças canadenses aumentou após a legalização.

29 Ago, 2022 | 17:15h

Hospitalizations for unintentional cannabis poisonings among Canadian children surged after legalization – The Ottawa Hospital

Estudo original: Edible Cannabis Legalization and Unintentional Poisonings in Children – New England Journal of Medicine ($)

 

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Documento de consenso | Tratamento da cirrose descompensada em UTI cirúrgica.

29 Ago, 2022 | 17:14h

Management of Decompensated Cirrhosis in the Surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document – Trauma Surgery & Acute Care Open

 

Comentário no Twitter

#TSACOTuesday 🔥 !
Check out what the AAST Critical Care Committee has to say about the managing Decompensated Cirrhotics in the SICU! https://t.co/lKVn9Y50xO pic.twitter.com/A4MQzaDvTk

— Trauma Surgery & Acute Care Open (TSACO) (@TSACO_AAST) August 2, 2022

 

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Estudo randomizado | Olokizumabe vs. placebo ou adalimumabe na artrite reumatoide.

29 Ago, 2022 | 17:13h

Olokizumab versus Placebo or Adalimumab in Rheumatoid Arthritis – New England Journal of Medicine (link para o resumo – $ para o texto completo)

Comentário: Novel IL-6 Blocker Matches Humira in Rheumatoid Arthritis – MedPage Today (necessário cadastro gratuito)

 

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Estudos randomizados | Ublituximabe vs. teriflunomida na esclerose múltipla recorrente.

29 Ago, 2022 | 17:11h

Ublituximab versus Teriflunomide in Relapsing Multiple Sclerosis – New England Journal of Medicine (link para o resumo – $ para o texto completo)

 

Comentário no Twitter

In two parallel randomized trials in patients with MS, ublituximab resulted in lower relapse rates and fewer brain lesions on MRI than teriflunomide over a period of 96 weeks but did not affect disability. https://t.co/fpdtYhTNER pic.twitter.com/EPJEetSVdS

— NEJM (@NEJM) August 24, 2022

 

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