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Estudo de coorte | Avaliação do risco de segundo câncer primário entre homens que receberam radioterapia vs. cirurgia para tratamento de câncer de próstata.

1 Ago, 2022 | 15:10h

Assessment of Second Primary Cancer Risk Among Men Receiving Primary Radiotherapy vs Surgery for the Treatment of Prostate Cancer – JAMA Network Open

Comentário no Twitter

In this cohort study of patients with localized prostate cancer, radiotherapy was associated with a small increase in the risk of developing a second primary cancer. https://t.co/YsrNo3FKwM

— JAMA Network Open (@JAMANetworkOpen) July 28, 2022

Estudo de coorte | Análise de prescrições para terapia antiplaquetária dupla após AVC isquêmico agudo.

1 Ago, 2022 | 15:09h

Analysis of Prescriptions for Dual Antiplatelet Therapy After Acute Ischemic Stroke – JAMA Network Open

Conteúdos relacionados:

Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ

Multiple versus fewer antiplatelet agents for preventing early recurrence after ischaemic stroke or transient ischaemic attack – Cochrane Library

2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association – Stroke

Stroke and transient ischaemic attack in over 16s: diagnosis and initial management – National Institute for Health and Care Excellence

Dual Antiplatelet Therapy Versus Aspirin in Patients With Stroke or Transient Ischemic Attack: Meta-Analysis of Randomized Controlled Trials – Stroke

Efficacy and Safety of Using Dual Versus Monotherapy Antiplatelet Agents in Secondary Stroke Prevention: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials – Circulation

Comentário no Twitter

In this cohort study, dual antiplatelet of aspirin and clopidogrel was underused in patients with minor ischemic stroke and potentially overused in non-minor ischemic stroke, with substantial hospital variations. https://t.co/rZeGbMgF1E

— JAMA Network Open (@JAMANetworkOpen) July 28, 2022

Resultados de longo prazo de um estudo randomizado | Manutenção ativa com olaparibe vs. placebo para câncer pancreático metastático com mutação no BRCA.

1 Ago, 2022 | 15:08h

Overall Survival Results From the POLO Trial: A Phase III Study of Active Maintenance Olaparib Versus Placebo for Germline BRCA-Mutated Metastatic Pancreatic Cancer – Journal of Clinical Oncology (link para o resumo – $ para o texto completo)

Comentário: Maintenance Olaparib vs Placebo in Germline BRCA-Mutated Metastatic Pancreatic Cancer: Overall Survival Analysis of the POLO Trial – The ASCO Post

Comentário no Twitter

OS data from the POLO trial of maintenance olaparib vs placebo for pts with BRCA-mutant PDAC reveal no significant benefit (median 19.0 vs 19.2 months) although the curves separated at 24 months & 3-yr OS was 33.9% vs 17.8%; other outcomes favour olaparib: https://t.co/JZ28MsGV0B

— NatureRevClinOncol (@NatRevClinOncol) July 20, 2022

M-A | Indicadores socioeconômicos do prognóstico de tratamento para adultos com depressão.

1 Ago, 2022 | 15:06h

Socioeconomic Indicators of Treatment Prognosis for Adults With Depression: A Systematic Review and Individual Patient Data Meta-analysis – JAMA Psychiatry

Comunicado de imprensa: People without jobs or secure housing have worse outcomes when treated for depression – University College London

Comentário: Unemployment and insecure housing are linked to less successful treatment for depression – National Institute for Health and Care Research

Comentário no Twitter

Socioeconomic disadvantage in employment and housing is associated with considerably worse outcomes in #depression, regardless of treatment type and after adjusting for clinical prognostic factors. https://t.co/bVTQv5zx8C

— JAMA Psychiatry (@JAMAPsych) May 6, 2022

Estudo de coorte | Riscos de AVC e doença cardíaca após histerectomia e ooforectomia em mulheres na pré-menopausa.

18 Jul, 2022 | 13:39h

Risks of Stroke and Heart Disease Following Hysterectomy and Oophorectomy in Chinese Premenopausal Women – Stroke

Comentário: Removal of Uterus, Ovaries Poses Extra Cardiovascular Risk for Younger Women – MedPage Today (necessário cadastro gratuito)

Revisão | Exames de imagem na síndrome da angústia respiratória aguda: passado, presente e futuro.

18 Jul, 2022 | 13:38h

Imaging the acute respiratory distress syndrome: past, present and future – Intensive Care Medicine

Comentário no Twitter

Imaging #ARDS: past, present & future
➡️ physiopathology
➡️ management: PEEP/recruitment; inflation (& hyperinfation)
➡️ effects of proning on ventilation/perfusion
➡️ lung infammation
➡️ #COVID19
➡️ identifying complications
➡️ prognostication
& more!
📎 https://t.co/tEp50muK8J pic.twitter.com/GlME1vTePh

— Intensive Care Medicine (@yourICM) July 14, 2022

Estudo randomizado | Tixagevimabe-cilgavimabe para tratamento de pacientes internados com COVID-19.

18 Jul, 2022 | 13:36h

Tixagevimab–cilgavimab for treatment of patients hospitalised with COVID-19: a randomised, double-blind, phase 3 trial – The Lancet Respiratory Medicine

Comentário: The potential of tixagevimab–cilgavimab for treating hospitalized COVID-19 patients – News Medical

Conteúdos relacionados:

Efficacy and safety of intramuscular administration of tixagevimab–cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trial – The Lancet Respiratory Medicine

Intramuscular AZD7442 (Tixagevimab–Cilgavimab) for Prevention of Covid-19 – New England Journal of Medicine

Comentário no Twitter

In pts hospitalised w/ COVID-19 receiving remdesivir and other standard care, tixagevimab–cilgavimab did not improve time to sustained recovery but was safe and mortality was lower vs placebo

From the ACTIV-3–TICO Study Group https://t.co/zaaXBQYl5t pic.twitter.com/xe0tmbFrZ9

— The Lancet Respiratory Medicine (@LancetRespirMed) July 11, 2022