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Revisão | Potássio e rim: relação recíproca com relevância clínica.

9 Ago, 2022 | 16:34h

Potassium and the kidney: a reciprocal relationship with clinical relevance – Pediatric Nephrology

 

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Estudo randomizado | Efeito do treinamento de estilo de vida ou farmacoterapia melhorada sobre o controle da pressão arterial entre adultos negros com hipertensão descontrolada persistente.

9 Ago, 2022 | 16:33h

Effect of Lifestyle Coaching or Enhanced Pharmacotherapy on Blood Pressure Control Among Black Adults With Persistent Uncontrolled Hypertension: A Cluster Randomized Clinical Trial – JAMA Network Open

Comentário: Lifestyle Coaching Intervention Improves BP Control Among Blacks – HealthDay

 

Comentário no Twitter

In this cluster randomized trial, a 1-year lifestyle coaching intervention (but not enhanced pharmacotherapy) was more effective than usual care in achieving blood pressure control at 2-4 years in Black adults with persistent uncontrolled hypertension. https://t.co/c7pZykQnFw

— JAMA Network Open (@JAMANetworkOpen) May 18, 2022

 

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Estudo randomizado | Lenvatinibe combinada com quimioembolização transarterial como tratamento de primeira linha para carcinoma hepatocelular avançado.

9 Ago, 2022 | 16:09h

Lenvatinib Combined With Transarterial Chemoembolization as First-Line Treatment for Advanced Hepatocellular Carcinoma: A Phase III, Randomized Clinical Trial (LAUNCH) – Journal of Clinical Oncology (link para o resumo – $ para o texto completo)

Comentário: Adding TACE to Lenvatinib Boosts Survival in Advanced Liver Cancer — In China-based trial, overall survival in first-line improved by 6 months versus lenvatinib alone – MedPage Today (necessário cadastroo gratuito)

 

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Estudo de fase 1 | Anticorpo monoclonal de baixa dose por via subcutânea ou intravenosa pode prevenir malária.

5 Ago, 2022 | 17:45h

Low-Dose Subcutaneous or Intravenous Monoclonal Antibody to Prevent Malaria – New England Journal of Medicine

Editorial: Monoclonal Antibodies for Malaria – New England Journal of Medicine

 

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Ponto de vista | Retirada de cuidados de baixo valor na cirurgia.

5 Ago, 2022 | 17:44h

Deimplementation of Low-Value Care in Surgery – JAMA Surgery (gratuito por tempo limitado)

 

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Melhorando a prevenção de AVC primário: uma abordagem combinada.

5 Ago, 2022 | 17:43h

Enhancing primary stroke prevention: a combination approach – The Lancet Public Health

 

Comentário no Twitter

Primary #stroke #prevention strategies target behavioural and pharmacological approaches. Also need to manage structural factors that support or hinder prevention actions and behaviours. @StrokeImperial @Simzy_x @Tsering_ @SomaBanerjee73 @CFCFoundation
https://t.co/vyyhhfeg7Y pic.twitter.com/kqwF9DROG2

— Joseph Kwan, MD 🇬🇧 (@drjkwan) July 31, 2022

Sob licença de Creative Commons Attribution (CC BY 4.0)

 

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Definições padronizadas para disfunção valvular bioprotética após substituição de válvula aórtica ou mitral.

5 Ago, 2022 | 17:42h

Standardized Definitions for Bioprosthetic Valve Dysfunction Following Aortic or Mitral Valve Replacement: JACC State-of-the-Art Review – Journal of the American College of Cardiology

 

Comentário no Twitter

Standardized Definitions for Bioprosthetic Valve Dysfunction Following Aortic or Mitral Valve Replacement: JACC State-of-the-Art Reviewhttps://t.co/xaUpRTD0rd@JACCJournals pic.twitter.com/IINRrOtXRY

— Giuseppe Biondi-Zoccai (@gbiondizoccai) July 26, 2022

Sob licença de http://creativecommons.org/licenses/by/4.0/

 

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Estudo randomizado | Seguimento pós-parto de 72 semanas de dolutegravir vs. efavirenz iniciado na gestação.

5 Ago, 2022 | 17:40h

72 weeks post-partum follow-up of dolutegravir versus efavirenz initiated in late pregnancy (DolPHIN-2): an open-label, randomised controlled study – The Lancet HIV

Conteúdos relacionados:

WHO Recommends Dolutegravir as Preferred HIV Treatment Option in All Populations

Week 96 results from a RCT: Efficacy and safety of dolutegravir or darunavir combined with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection.

RCT: Efficacy and safety of switching to the 2-drug regimen Dolutegravir/Lamivudine vs. continuing a 3- or 4-Drug regimen for maintaining virologic suppression in adults living with HIV-1.

RCT: Low-cost, easy to take antiretroviral treatment based on Dolutegravir as first- or second-Line therapy found to be non-inferior to standard care for treating HIV-1 infection in children.

RCT: Dolutegravir or Darunavir in combination with Zidovudine or Tenofovir to treat HIV.

Randomized controlled trial compared three antiretroviral regimens started in pregnant women with HIV

Randomized Trial: Switching to Dolutegravir/Lamivudine Two-Drug Regimen Noninferior to Continuing a Tenofovir Alafenamide–Based Three- or Four-Drug Regimen for Maintenance of Virologic Suppression in Adults With HIV-1

 

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Estudo de caso-controle | Uso ambulatorial de macrolídeo oral está associado com risco aumentado de perda de audição neurossensorial em crianças, adolescentes e jovens adultos.

5 Ago, 2022 | 17:39h

Association of Outpatient Oral Macrolide Use With Sensorineural Hearing Loss in Children, Adolescents, and Young Adults – JAMA Otolaryngology-Head & Neck Surgery (link para o resumo – $ para o texto completo)

Comentário: Kids’ Hearing Loss Associated With Common Antibiotics — Children and teens with sensorineural hearing loss more often macrolide users – MedPage Today (necessário cadastro gratuito)

 

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Estudo de coorte | Risco de overdose de opioide é aumentado pelo uso concomitante de oxicodona e inibidores seletivos de recaptação de serotonina que inibem o metabolismo da oxicodona.

5 Ago, 2022 | 17:37h

Risk of Opioid Overdose Associated With Concomitant Use of Oxycodone and Selective Serotonin Reuptake Inhibitors – JAMA Network Open

Comentário do autor: Taking certain opioids while on commonly prescribed antidepressants may increase the risk of overdose – The Conversation

 

Comentário no Twitter

This cohort study found that concomitant use of oxycodone with potent CYP2D6-inhibiting serotonin reuptake inhibitors (SSRIs, eg. fluoxetine or paroxetine) is associated with an increased risk of overdose. https://t.co/Eol89RHWAu

— JAMA Network Open (@JAMANetworkOpen) February 24, 2022

 

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