Todos os posts

Estudo randomizado | Radiação paliativa para tumores pulmonares centrais avançados com proteção intencional do esôfago.

10 Ago, 2022 | 14:13h

Palliative Radiation for Advanced Central Lung Tumors With Intentional Avoidance of the Esophagus (PROACTIVE): A Phase 3 Randomized Clinical Trial – JAMA Oncology

Comentário: Esophagus-Sparing Radiation Fails QOL Test in Lung Cancer— Esophageal-specific quality of life no better, but treatment reduced symptomatic esophagitis – MedPage Today (necessário cadastro gratuito)

 

Comentário no Twitter

PROACTIVE was a phase 3 RCT of 90 pts with incurable lung cancer treated with esophageal sparing IMRT vs. standard palliative RT. ES-IMRT did not improve FACT-E ECS quality of life scores at 2wks but reduced grade≥2 esophagitis (24% vs. 2%). https://t.co/ExIp22WBPe #RadOnc #LCSM pic.twitter.com/lX8lD4Duja

— JAMA Oncology (@JAMAOnc) February 24, 2022

 

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Estudo de braço único fase 2 | Seguimento de longo prazo da combinação entre antígeno de maturação de célula B e células T receptoras de antígeno quimérico CD19 no mieloma múltiplo.

10 Ago, 2022 | 14:12h

Long-Term Follow-Up of Combination of B-Cell Maturation Antigen and CD19 Chimeric Antigen Receptor T Cells in Multiple Myeloma – Journal of Clinical Oncology (link para o resumo – $ para o texto completo)

Comentário: Durable Response Achieved With CAR-T Combination in Relapsed/Refractory Multiple Myeloma – Hematology Advisor

 

Comentário no Twitter

🙌 Combination of anti-BCMA and anti-CD19 CAR T cells induced durable response in patients with relapsed/refractory #MultipleMyeloma ➡️ https://t.co/TkPRcTKSxg #JCO #MMSM pic.twitter.com/0OZAJtTXF1

— Journal of Clinical Oncology (@JCO_ASCO) April 15, 2022

 

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Estudo de coorte | Impacto do status baixo vs. negativo do receptor de estrogênio/progesterona sobre as características clínico-patológicas e os desfechos de sobrevida no câncer de mama HER2-negativo.

10 Ago, 2022 | 14:10h

Impact of low versus negative estrogen/progesterone receptor status on clinico-pathologic characteristics and survival outcomes in HER2-negative breast cancer – npj Breast Cancer

 

Comentário no Twitter

Out on NPJ Breast a new report on #ERlowtumors. No difference in characteristics, pCR rates, RFS os OS compared with #TNBC. Patients with ER-low tumors should be treated as for TNBC. Also, important confounder to remember in HER2-low prognostic analyses.https://t.co/M1GF8eyYbT pic.twitter.com/CrLyUgyhUV

— Paolo Tarantino (@PTarantinoMD) July 11, 2022

 

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Diretriz clínica ACG | Gastroparesia.

9 Ago, 2022 | 17:38h

ACG Clinical Guideline: Gastroparesis – The American Journal of Gastroenterology

Conteúdos relacionados: United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis – UEG Journal

 

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Diretriz de posicionamento | Uso de albumina na cirrose hepática.

9 Ago, 2022 | 17:36h

Position statement on the use of albumin in liver cirrhosis – Annals of Hepatology

 

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Estudo randomizado | Efeito da semaglutida 1 vez/semana vs. insulina aspart 3 vezes/dia, ambas adicionadas à metformina e ao tratamento otimizado com insulina glargina em participantes com diabetes tipo 2.

9 Ago, 2022 | 17:34h

Effect of once-weekly semaglutide versus thrice-daily insulin aspart, both as add-on to metformin and optimized insulin glargine treatment in participants with type 2 diabetes (SUSTAIN 11): A randomized, open-label, multinational, phase 3b trial – Diabetes, Obesity and Metabolism

 

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Estudo randomizado | Agentes antissépticos cutâneos para prevenir infecção de sítio cirúrgico após cirurgia incisional.

9 Ago, 2022 | 17:33h

Antiseptic Skin Agents to Prevent Surgical Site Infection After Incisional Surgery: A Randomized, Three-armed Combined Non-inferiority and Superiority Clinical Trial (NEWSkin Prep Study) – Annals of Surgery (link para o resumo – $ para o texto completo)

Conteúdos relacionados:

Alcoholic chlorhexidine skin preparation or triclosan-coated sutures to reduce surgical site infection: a systematic review and meta-analysis of high-quality randomised controlled trials – The Lancet Infectious Diseases

Reducing surgical site infections in low-income and middle-income countries (FALCON): a pragmatic, multicentre, stratified, randomised controlled trial – The Lancet

 

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Dois estudos randomizados mostraram que anticorpos monoclonais não são melhores que placebo para doença de Parkinson.

9 Ago, 2022 | 17:31h

Estudo 1: Trial of Cinpanemab in Early Parkinson’s Disease – New England Journal of Medicine (link para o resumo – $ para o texto completo)

Estudo 2: Trial of Prasinezumab in Early-Stage Parkinson’s Diseas – New England Journal of Medicine (link para o resumo – $ para o texto completo)

Comentário: Monoclonal Antibodies No Better Than Placebo for Early Parkinson Disease – HealthDay

 

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Revisão sistemática | Impacto do rastreamento por tomografia computadorizada com baixa dose de radiação sobre a mortalidade relacionada a câncer de pulmão.

9 Ago, 2022 | 17:29h

Impact of low‐dose computed tomography (LDCT) screening on lung cancer‐related mortality – Cochrane Library

Resumo: Impact of computed tomography (CT) on lung cancer screening – Cochrane Library

Conteúdos relacionados:

Association of computed tomography screening with lung cancer stage shift and survival in the United States: quasi-experimental study – The BMJ

Screening for Lung Cancer: CHEST Guideline and Expert Panel Report.

USPSTF Statement: begin screening for lung cancer at age 50 years instead of 55 years for patients at risk

Meta-analysis: Lung cancer screening using low-dose computed tomography reduces lung cancer–specific mortality, albeit with a tradeoff of likely overdiagnosis

 

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Coleção Cochrane | Atingindo a atenção sustentável à saúde por meio da retirada de medicamentos desnecessários.

9 Ago, 2022 | 17:27h

Achieving sustainable healthcare through deprescribing of unnecessary medications: making sense of the evidence – Cochrane Library

 

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