Saúde Pública/Medicina Humanitária

Opinião | Lição da COVID: confie no público com verdades concretas.

13 Out, 2021 | 13:42h

COVID lesson: trust the public with hard truths – Nature

Comentário do autor no Twitter (fio – clique para saber mais)

Today in @Nature, I outline a key lesson from COVID-19:

"Governments, dare to to trust your citizens."

Governments' fear of their people is not supported by science & it stymies pandemic management and breeds vaccine hesitancy.

Read it here: https://t.co/dbr5Epggow.

🧵 (1/8) pic.twitter.com/EegEIxGb2r

— Michael Bang Petersen (@M_B_Petersen) October 12, 2021

Uma cartilha sobre o que se sabe a respeito de misturar e combinar vacinas contra Covid.

13 Out, 2021 | 13:40h

A primer on what we know about mixing and matching Covid vaccines – STAT

Conteúdos relacionados:

Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination.

RCT: Safety and immunogenicity of heterologous vs. homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine.

Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.

Heterologous Oxford–AstraZeneca and Moderna Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

Heterologous Oxford–AstraZeneca and BioNTech/Pfizer Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

[Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”.

Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”.

Lab study shows heterologous AstraZeneca/Pfizer vaccination produces strong immune response against SARS-CoV-2 Delta variant.

Lab study shows a heterologous AstraZeneca + Pfizer immunization strategy provides stronger immunogenicity against Covid compared to homologous AZ + AZ or Pfizer + Pfizer strategies.

RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.

Dados de vida real mostram que filtros eliminam do ar o vírus causador da COVID.

13 Out, 2021 | 13:39h

Real-world data show that filters clean COVID-causing virus from air – Nature

Artigo original: The removal of airborne SARS-CoV-2 and other microbial bioaerosols by air filtration on COVID-19 surge units – medRxiv

Comentário no Twitter

Research at a hospital swamped by people with COVID-19 has confirmed that portable air filters effectively remove SARS-CoV-2 particles from the air https://t.co/OT3JKIxWhB

— nature (@Nature) October 11, 2021

Soroconversão e febre são fatores dose-dependentes em um modelo primata não humano de COVID-19 inalatória.

13 Out, 2021 | 13:37h

Seroconversion and fever are dose-dependent in a nonhuman primate model of inhalational COVID-19 – PLOS Pathogens

Comentário: Dose-dependent COVID-19 symptoms – Nature Reviews Microbiology

Comentários no Twitter

When exposed to #SARSCoV2 why does one person have no illness, while another is soon in ICU?
Dose.
Controlled study in monkeys shows the dose of viruses inhaled is a key factor determining the severity of the disease.
Seems obvious, yet this is new.https://t.co/zdfCnR40bR pic.twitter.com/HH8kxMM2xm

— Laurie Garrett (@Laurie_Garrett) October 11, 2021

In summer of 2020, our group had proposed a hypothesis that SARS-CoV-2 viral dose or "inoculum" was associated with severity of symptoms in COVID (and proposed NPIs reduced the dose). There is now an experimental model showing this in cynomolgus monkeys:https://t.co/dXGDPyPBFZ

— Monica Gandhi MD, MPH (@MonicaGandhi9) October 12, 2021

Revisão | Dieta ótima para a saúde cardiovascular e planetária.

13 Out, 2021 | 13:14h

Optimal diet for cardiovascular and planetary health – Heart

Prevalência de anemia em mulheres em idade reprodutiva nos países de baixa e média rendas entre 2000 e 2018.

13 Out, 2021 | 13:13h

Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018 – Nature Medicine

Comentário convidado: Anemia in women — an intractable problem that requires innovative solutions – Nature Medicine

Estudo nacional na Suécia mostra ligação entre vacinação contra COVID e redução na transmissão domiciliar.

13 Out, 2021 | 12:53h

Comunicado de imprensa: Nationwide study shows link between COVID vaccination and reduced household transmission – Umea University

Estudo original: Association Between Risk of COVID-19 Infection in Nonimmune Individuals and COVID-19 Immunity in Their Family Members – JAMA Internal Medicine

Conteúdos relacionados:

Review | Prevention of host-to-host transmission by SARS-CoV-2 vaccines.

Study ties COVID vaccines to lower transmission rates.

Effect of Vaccination on Household Transmission of SARS-CoV-2 in England – “the likelihood of household transmission was approximately 40 to 50% lower in households of index patients who had been vaccinated 21 days or more before testing positive than in households of unvaccinated index patients”.

Study in England showed one dose of COVID-19 vaccine can cut household transmission by up to half – This protection is on top of the reduced risk of a vaccinated person developing symptomatic infection, which is around 60 to 65% after the first dose

Covid-19 vaccination prevents transmission from vaccinated to unvaccinated household members.

Covid-19: a mudança na política da Nova Zelândia é um avanço ou um retrocesso?

13 Out, 2021 | 12:51h

Covid-19: Is New Zealand’s switch in policy a step forward or a retreat? – The BMJ

Conteúdos relacionados:

New Zealand acknowledges it can no longer completely get rid of the coronavirus.

Why we must not allow COVID to become endemic in New Zealand – The Conversation

Comentário no Twitter

On 4 October New Zealand's prime minister announced that the country was shifting from a policy of elimination to a mitigation approach more in line with policies in other developed countries.

What comes next and what lessons have been learnt?https://t.co/Z62olXHzb9

— The BMJ (@bmj_latest) October 11, 2021

Relatório especial da OMS sobre mudança climática e saúde.

13 Out, 2021 | 12:46h

Comunicado de imprensa: WHO’s 10 calls for climate action to assure sustained recovery from COVID-19 – World Health Organization

Relatório: COP26 Special Report on Climate Change and Health – World Health Organization

Comentário: ‘Burning of Fossil Fuels is Killing Us’ – Declares New WHO Climate and Health Report – Health Policy Watch

Comentário no Twitter (fio – clique para saber mais)

#ClimateCrisis harms our health!#ClimateCrisis harms our health!#ClimateCrisis harms our health!

Limiting global warming to 1.5°C isn't only the right thing to do but also a shared responsibility for health.

🆕 WHO #COP26 Special Report explains why 👉https://t.co/WXMdMgPSWv pic.twitter.com/r8NFs1oI37

— World Health Organization (WHO) (@WHO) October 11, 2021