Radioterapia

Estudo randomizado | Doses de radiação e esquemas de fracionamento no carcinoma ductal in situ mamário de não baixo risco.

10 Ago, 2022 | 14:28h

Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3–07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study – The Lancet (link para o resumo – $ para o texto completo)

 

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Estudo randomizado | Radiação paliativa para tumores pulmonares centrais avançados com proteção intencional do esôfago.

10 Ago, 2022 | 14:13h

Palliative Radiation for Advanced Central Lung Tumors With Intentional Avoidance of the Esophagus (PROACTIVE): A Phase 3 Randomized Clinical Trial – JAMA Oncology

Comentário: Esophagus-Sparing Radiation Fails QOL Test in Lung Cancer— Esophageal-specific quality of life no better, but treatment reduced symptomatic esophagitis – MedPage Today (necessário cadastro gratuito)

 

Comentário no Twitter

PROACTIVE was a phase 3 RCT of 90 pts with incurable lung cancer treated with esophageal sparing IMRT vs. standard palliative RT. ES-IMRT did not improve FACT-E ECS quality of life scores at 2wks but reduced grade≥2 esophagitis (24% vs. 2%). https://t.co/ExIp22WBPe #RadOnc #LCSM pic.twitter.com/lX8lD4Duja

— JAMA Oncology (@JAMAOnc) February 24, 2022

 

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Estudo randomizado | Irradiação mamária parcial vs. total para câncer de mama precoce.

9 Ago, 2022 | 17:16h

Partial Breast Irradiation Versus Whole Breast Irradiation for Early Breast Cancer Patients in a Randomized Phase III Trial: The Danish Breast Cancer Group Partial Breast Irradiation Trial – Journal of Clinical Oncology (link para o resumo – $ para o texto completo)

 

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Diretriz ASTRO | Radioterapia para glioma difuso IDH-mutante grau 2 e grau 3.

1 Ago, 2022 | 15:20h

Radiation Therapy for IDH-Mutant Grade 2 and Grade 3 Diffuse Glioma: An ASTRO Clinical Practice Guideline – Practical Radiation Oncology

 

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Estudo de coorte | Avaliação do risco de segundo câncer primário entre homens que receberam radioterapia vs. cirurgia para tratamento de câncer de próstata.

1 Ago, 2022 | 15:10h

Assessment of Second Primary Cancer Risk Among Men Receiving Primary Radiotherapy vs Surgery for the Treatment of Prostate Cancer – JAMA Network Open

 

Comentário no Twitter

In this cohort study of patients with localized prostate cancer, radiotherapy was associated with a small increase in the risk of developing a second primary cancer. https://t.co/YsrNo3FKwM

— JAMA Network Open (@JAMANetworkOpen) July 28, 2022

 

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Estudo randomizado fase 2 | Eficácia de mFOLFIRINOX pré-operatório vs. mFOLFIRINOX com radioterapia hipofracionada para adenocarcinoma ressecável limítrofe do pâncreas.

18 Jul, 2022 | 13:16h

Efficacy of Preoperative mFOLFIRINOX vs mFOLFIRINOX Plus Hypofractionated Radiotherapy for Borderline Resectable Adenocarcinoma of the PancreasThe A021501 Phase 2 Randomized Clinical Trial – JAMA Oncology (gratuito por tempo limitado)

Editorial: The Continued Struggle for Defining a Role for Radiotherapy in Pancreas Cancer – JAMA (gratuito por tempo limitado)

Comunicado de imprensa: Preoperative combination chemotherapy improved survival in patients with pancreatic cancer – The University of Texas MD Anderson Cancer Center

 

Comentário no Twitter

Ph 2 trial of 126 pts w/borderline resectable pancreatic ductal adenoCa shows 18 mo OS after neoadjuvant mFOLFIRINOX of 66.7%, favorable vs. historical data; 18m OS if mFOLFORINOX then hypofract RT is 47.3%, if chemo then pancreatectomy is 87.5%. https://t.co/wOMNrTOAzm

— JAMA Oncology (@JAMAOnc) July 14, 2022

 

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Revisão de escopo | Tecidos eréteis femininos e disfunção sexual após radioterapia pélvica.

14 Jul, 2022 | 11:40h

Female erectile tissues and sexual dysfunction after pelvic radiotherapy: A scoping review – CA: A Cancer Journal for Clinicians

 

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Estudo randomizado de fase 2 | Irradiação craniospinal de prótons vs. radioterapia de campo envolvido de fótons para pacientes com metástase leptomeníngea de tumor sólido.

14 Jul, 2022 | 11:30h

Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis – Journal of Clinical Oncology (link para o resumo – $ para texto completo)

 

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M-A de rede | Radioterapia em alta dose ou terapia de deprivação androgênica como intensificadores do tratamento para câncer de próstata localizado.

7 Jul, 2022 | 11:46h

High-dose Radiotherapy or Androgen Deprivation Therapy (HEAT) as Treatment Intensification for Localized Prostate Cancer: An Individual Patient–data Network Meta-analysis from the MARCAP Consortium – European Urology (link para o resumo – $ para o texto completo)

 

Comentário no Twitter

New In Press: High-dose Radiotherapy or Androgen Deprivation Therapy (HEAT) as Treatment Intensification for Localized Prostate Cancer: An Individual Patient–data Network Meta-analysis from the MARCAP Consortiumhttps://t.co/rZnBjvccNe@AmarUKishan @DrSpratticus et al. pic.twitter.com/uCrg7sRmsS

— European Urology (@EUplatinum) April 25, 2022

 

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Resultados de longo prazo de estudo randomizado | Radioterapia prostática para homens com câncer de próstata metastático.

16 Jun, 2022 | 13:37h

Radiotherapy to the prostate for men with metastatic prostate cancer in the UK and Switzerland: Long-term results from the STAMPEDE randomised controlled trial – PLOS Medicine

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