Psiquiatria

M-A | Antidepressivos em crianças e adolescentes com transtorno depressivo maior e a influência da resposta ao placebo.

6 Jun, 2022 | 11:10h

Antidepressants in children and adolescents with major depressive disorder and the influence of placebo response: A meta-analysis – Journal of Affective Disorders (link para o resumo – $ para o texto completo)

Comentários:

Antidepressants Have Small Effect Sizes for the Treatment of Major Depressive Disorder Among Children – Psychiatry Advisor

Antidepressant Effect Sizes Modest for Pediatric Major Depressive Disorder – Consultant360

Comentário no Twitter

MA: The SMD among all studies of antidepressants in C&A with MDD was 0.12 (0.08-0.17), a very small ES, lower than that seen in studies of adults with MDD. When the MA was limited to studies with a low mean placebo response, the SMD increased to 0.19 https://t.co/hPYvta4rgf

— PfOL (@psychopharmacol) March 23, 2022

Estudo de coorte | Avaliação de desfechos neurológicos e psiquiátricos após alta hospitalar entre adultos sobreviventes de parada cardíaca.

6 Jun, 2022 | 11:02h

Evaluation of Neurologic and Psychiatric Outcomes After Hospital Discharge Among Adult Survivors of Cardiac Arrest – JAMA Network Open

M-A | Prevalência e correlações da autolesão suicida e não suicida em crianças.

1 Jun, 2022 | 13:28h

Prevalence and Correlates of Suicide and Nonsuicidal Self-injury in Children: A Systematic Review and Meta-analysis – JAMA Psychiatry (link para o resumo – $ para o texto completo)

Comentário no Twitter

In this meta-analysis of self-harm in children, suicidal ideation, #suicide attempts and nonsuicidal self-injury occurred at concerning rates. Males, child maltreatment, ADHD and depression may be linked to risk. https://t.co/Nw25EuKfwW @rachel__walsh @AnaSheehan19 @csanzari_

— JAMA Psychiatry (@JAMAPsych) May 25, 2022

Estudo de coorte | Análise de diagnósticos neuropsiquiátricos após início do uso de montelucaste.

26 Mai, 2022 | 13:09h

Analysis of Neuropsychiatric Diagnoses After Montelukast Initiation – JAMA Network Open

Conteúdos relacionados:

FDA requires Boxed Warning about serious mental health side effects for asthma and allergy drug montelukast (Singulair); advises restricting use for allergic rhinitis – U.S. Food & Drug Administration

Adverse drug reactions of montelukast in children and adults – Pharmacology Research & Perspectives

Comentário no Twitter

This cohort study of patients with asthma or allergic rhinitis found montelukast use is associated with higher odds of neuropsychiatric outcomes, including anxiety and insomnia. https://t.co/HAzcADsHZc

— JAMA Network Open (@JAMANetworkOpen) May 24, 2022

Comentário de estudo | Biomarcadores para depressão presentes em líquido cerebrospinal.

26 Mai, 2022 | 12:54h

Cerebrospinal fluid biomarkers for depression – The Mental Elf

Estudo original: Cerebrospinal Fluid Biomarkers in Patients With Unipolar Depression Compared With Healthy Control Individuals: A Systematic Review and Meta-analysis – JAMA Psychiatry (link para o resumo – $ para o texto completo)

Comentário no Twitter

Comprehensive systematic review and meta-analysis of all cerebrospinal fluid studies in #depression investigating contrast to healthy controls (165 biomarkers from 97 studies) pointing at several biological mechanisms and future directions. https://t.co/gcjFBjYJhi @MichaelBenros

— JAMA Psychiatry (@JAMAPsych) April 25, 2022