Oncologia

Revisão | Panorama do tratamento do câncer de mama triplo-negativo.

16 Nov, 2021 | 12:25h

Treatment landscape of triple-negative breast cancer — expanded options, evolving needs – Nature Reviews Clinical Oncology (gratuito por tempo limitado)

Comentário no Twitter

A Review in @NatRevClinOncol describes the current and upcoming therapeutic landscape of triple-negative breast cancer. https://t.co/bcFTef01t1 pic.twitter.com/zFPyeeCnD5

— Nature Portfolio (@NaturePortfolio) November 15, 2021

Desfechos de longo prazo de pacientes com metástase cerebral ativa de melanoma tratados com a combinação nivolumabe e ipilimumabe.

16 Nov, 2021 | 12:17h

Long-term outcomes of patients with active melanoma brain metastases treated with combination nivolumab plus ipilimumab (CheckMate 204): final results of an open-label, multicentre, phase 2 study – The Lancet Oncology (link para o resumo – $ para o texto completo)

Comentário: Combination immunotherapy improves survival for patients with asymptomatic melanoma brain metastases – The University of Texas MD Anderson Cancer Center

Estudo original: Study: Combination Immunotherapy for Melanoma Brain Metastases

Conteúdo relacionado: #ESMO19 – Randomized Trial: Improved Overall Survival at 5 Years with Combined Immunotherapy for Advanced Melanoma

De acordo com estudo, vacinas contra SARS-CoV-2 são seguras e imunogênicas na maioria das pessoas com câncer.

15 Nov, 2021 | 13:56h

Comunicado de imprensa: SARS-CoV-2 vaccines are safe and immunogenic in most people with cancer, according to study – Harvard Medical School

Estudo original: Immunogenicity and Reactogenicity of SARS-CoV-2 Vaccines in Patients With Cancer: The CANVAX Cohort Study – Journal of Clinical Oncology

Comentário do autor no Twitter (fio – clique para saber mais)

The CANVAX study is out in @JCO_ASCO! https://t.co/WKrU6dQIEB
Grateful to >1000 CANVAX participants, study leads ( @JustinGainor, @MGHPathology, @BalazsLab) and so many co-authors incl. @arthur_kim_ID, @KimberlyBlumen1, @joanhowMD, @dradityabardia
Much more to come!

— Vivek Naranbhai, MD, PhD, DPhil (@vivek_naranbhai) November 10, 2021

Alguns imunoterápicos usados no tratamento do câncer podem causas arritmias graves e miocardite.

12 Nov, 2021 | 13:29h

Comunicado de imprensa: Some immune checkpoint inhibitors can cause serious arrhythmias and myocarditis – University of California San Francisco Medical Center

Estudo original: Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis – Circulation (link para o resumo – $ para o texto completo)

Conteúdos relacionados:

Anticancer drug-induced life-threatening ventricular arrhythmias: a World Health Organization pharmacovigilance study.

AHA Scientific Statement: Recognition, prevention, and management of arrhythmias and autonomic disorders in cardio-oncology.

Quase metade dos pacientes com câncer em uso de gastrostomia descompressiva para nutrição ou obstrução intestinal apresentava doença estágio IV e faleceu em 1 mês da colocação do tubo.

12 Nov, 2021 | 13:27h

Gastrostomy Tube for Nutrition and Malignant Bowel Obstruction in Patients with Cancer – Journal of the National Comprehensive Cancer Network

Comentário: Risks and Benefits Associated With Gastrostomy Tubes for Patients With Cancer – The ASCO Post

Revisão clínica sobre o tratamento de câncer de mama metastático positivo para receptor hormonal.

11 Nov, 2021 | 15:58h

Clinical Review on the Management of Hormone Receptor–Positive Metastatic Breast Cancer – JCO Oncology Practice

Estudo randomizado | Rastreamento com sigmoidoscopia flexível uma única vez está associado com redução, no longo prazo, da incidência e mortalidade por câncer colorretal.

10 Nov, 2021 | 12:41h

Long-Term Follow-up of the Italian Flexible Sigmoidoscopy Screening Trial – Annals of Internal Medicine

Comentários:

Flexible sigmoidoscopy associated with long-term reduction in colorectal cancer incidence, mortality – ACP Internist

Flexible sigmoidoscopy screening associated with long-term reduction in colorectal cancer incidence and mortality – American College of Physicians

Estudo de coorte | Exposição intraútero a 17-alfa-hidroxiprogesterona está associada a risco aumentado de câncer nos descendentes.

10 Nov, 2021 | 12:38h

In utero exposure to 17α-hydroxyprogesterone caproate and risk of cancer in offspring – American Journal of Obstetrics and Gynecology (link para o resumo – $ para o texto completo)

Comentário: Drug used to prevent miscarriage increases risk of cancer in offspring – The University of Texas Health Science Center at Houston

Conteúdo relacionado: Randomized Trial: Injectable 17-α-hydroxyprogesterone Not Effective for the Prevention of Recurrent Preterm Birth

Amplo estudo observacional sugere a associação entre antipsicóticos que aumentam a prolactina e risco aumentado de câncer de mama (OR = 1,56 para mais de 5 anos de exposição); por outro lado, antipsicóticos poupadores de prolactina (clozapina, quetiapina ou aripiprazol) não estão associados a tal risco.

10 Nov, 2021 | 12:36h

Antipsychotic use and risk of breast cancer in women with schizophrenia: a nationwide nested case-control study in Finland – The Lancet Psychiatry (link para o resumo – $ para o texto completo)

Comentário: Choosing between antipsychotics to reduce the risk of breast cancer in women with schizophrenia – The Mental Elf

Comentário no Twitter

Nested case-control study: ≥5 years exposure to prolactin-sparing APDs was not associated with an increased risk of breast cancer vs.<1 year exposure (aOR=1.19; 0.90–1.58). The opposite was observed with APDs that increase prolactin (aOR=1.56; 1.27–1.92) https://t.co/LwCVyTH051

— PfOL (@psychopharmacol) September 12, 2021

Linfadenopatia regional pós-vacinação contra COVID-19: revisão da literatura e considerações para a abordagem de pacientes em tratamento de câncer de mama.

9 Nov, 2021 | 12:22h

Regional lymphadenopathy following COVID-19 vaccination: Literature review and considerations for patient management in breast cancer care – European Journal of Cancer

Conteúdos relacionados:

2 Case Series and Guidance | Lymphadenopathy in COVID-19 Vaccine Recipients

Axillary lymphadenopathy at the time of COVID-19 vaccination: ten recommendations from the European Society of Breast Imaging.

Covid-19: Schedule breast screening before vaccine or 4 to 6 weeks after to avoid false positives, says guidance