Oncologia

Estudo randomizado | Tomografia computadorizada vs. [18F]FDG-PET-TC para febre neutropênica persistente ou recorrente em pacientes de alto risco.

5 Jul, 2022 | 11:37h

[18F]FDG-PET-CT compared with CT for persistent or recurrent neutropenic fever in high-risk patients (PIPPIN): a multicentre, open-label, phase 3, randomised, controlled trial – The Lancet Haematology (link para o resumo – $ para o texto completo)

Comentário no Twitter

NEW research: [18F]FDG-PET-CT resulted in more frequent antimicrobial rationalisation than CT in patients w/ haem diseases & persistent/recurrent high-risk neutropenic fever after chemotherapy. Results of the ph3 RCT PIPPIN #radonc #hemonc https://t.co/isOPFZVVpY pic.twitter.com/PVd8yFy7Ck

— The Lancet Haematology (@TheLancetHaem) June 29, 2022

Estudo randomizado | Efeito do levofloxacino sobre a eficácia e os eventos adversos no tratamento intravesical com BCG para câncer de bexiga.

5 Jul, 2022 | 11:34h

Effect of Levofloxacin on the Efficacy and Adverse Events in Intravesical Bacillus Calmette-Guerin Treatment for Bladder Cancer: Results of a Randomized, Prospective, Multicenter Study – European Urology Focus

Estudo de braço único fase 1 | Vírus DNX-2401 oncolítico para glioma pontino intrínseco difuso pediátrico.

5 Jul, 2022 | 11:25h

Oncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma – New England Journal of Medicine (link para o resumo – $ para o texto completo)

Comentário: Oncolytic Virus Infusion Promising as Brain-Stem Glioma Treatment — Phase I trial shows encouraging OS in children with diffuse intrinsic pontine glioma – MedPage Today (necessário cadastro gratuito)

Diretrizes 2022 para o tratamento e a profilaxia do tromboembolismo venoso em pacientes com câncer, incluindo aqueles com COVID-19.

4 Jul, 2022 | 12:24h

2022 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer, including patients with COVID-19 – The Lancet Oncology

Conteúdos relacionados:

Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy – Cochrane Library

American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer – Blood Advances

Cancer-Associated Venous Thromboembolic Disease, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology – Journal of the National Comprehensive Cancer Network

Venous and Arterial Thromboembolism in Patients With Cancer: JACC: CardioOncology State-of-the-Art Review

Diretriz rápida da UEG e EAES sobre excisão mesorretal total transanal para câncer retal.

4 Jul, 2022 | 12:14h

UEG and EAES rapid guideline: Systematic review, meta-analysis, GRADE assessment and evidence-informed European recommendations on TaTME for rectal cancer – Surgical Endoscopy

Estudo randomizado | Oxaliplatina (3 meses vs. 6 meses) com 6 meses de fluoropirimidina como terapia adjuvante em pacientes com câncer de cólon estágios II/III.

4 Jul, 2022 | 11:54h

Oxaliplatin (3 months v 6 months) With 6 Months of Fluoropyrimidine as Adjuvant Therapy in Patients With Stage II/III Colon Cancer: KCSG CO09-07 – Journal of Clinical Oncology

Estudo relacionado: Final Analysis of 3 Versus 6 Months of Adjuvant Oxaliplatin and Fluoropyrimidine-Based Therapy in Patients With Stage III Colon Cancer: The Randomized Phase III ACHIEVE Trial – Journal of Clinical Oncology

Estudo randomizado | Efeito da intervenção de trabalhadores da saúde da comunidade sobre uso do cuidado intensivo, planejamento de cuidado avançado e desfechos relatados pelo paciente entre adultos com câncer em estágios avançados.

4 Jul, 2022 | 11:53h

Effect of a Community Health Worker Intervention on Acute Care Use, Advance Care Planning, and Patient-Reported Outcomes Among Adults With Advanced Stages of Cancer: A Randomized Clinical Trial – JAMA Oncology (gratuito por tempo limitado)

Ver também: Visual Abstract

Estudo randomizado | Efeitos da estratégia perioperatória de “enhanced recovery” após esofagectomia minimamente invasiva.

4 Jul, 2022 | 11:51h

The effect of enhanced recovery after minimally invasive esophagectomy: a randomized controlled trial – Surgical Endoscopy

Conteúdos relacionados:

Guidelines for Perioperative Care in Esophagectomy: Enhanced Recovery After Surgery (ERAS^®) Society Recommendations – World Journal of Surgery

Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines

Top 100 Most-Cited Articles on Enhanced Recovery After Surgery: A Bibliometric Analysis and Visualized Study – Frontiers in Surgery

Guide to Enhanced Recovery for Cancer Patients Undergoing Surgery: ERAS and Oesophagectomy – Annals of Surgical Oncology

Resumo visual: ASO Visual Abstract: Guide to Enhanced Recovery for Cancer Patients Undergoing Surgery—ERAS and Esophagectomy

Enhanced recovery after surgery (ERAS) programs for esophagectomy – Journal of Thoracic Disease

Estudo randomizado | Efeito de apatinibe com doxorrubicina lipossomal peguilada vs. doxorrubicina lipossomal peguilada isoladamente sobre o câncer ovariano recidivante resistente à platina.

4 Jul, 2022 | 11:30h

Effect of Apatinib Plus Pegylated Liposomal Doxorubicin vs Pegylated Liposomal Doxorubicin Alone on Platinum-Resistant Recurrent Ovarian Cancer: The APPROVE Randomized Clinical Trial – JAMA Oncology

Ver também: Visual Abstract

Estudo randomizado | Atezolizumabe com terapia neoadjuvante antirreceptor 2 do fator de crescimento epidérmico humano e quimioterapia no câncer de mama inicial positivo para receptor 2 do fator de crescimento epidérmico humano.

4 Jul, 2022 | 11:29h

Atezolizumab With Neoadjuvant Anti–Human Epidermal Growth Factor Receptor 2 Therapy and Chemotherapy in Human Epidermal Growth Factor Receptor 2–Positive Early Breast Cancer: Primary Results of the Randomized Phase III IMpassion050 Trial – Journal of Clinical Oncology

Comentário: Atezolizumab Does Not Improve pCR in HER2-Positive Early Breast Cancer – OncLive