Neurologia

Revisão sistemática atualizada e metanálise de estudos clínicos e pré-clínicos | Efeito poupador de opioides dos canabinoides para analgesia.

19 Jun, 2022 | 13:49h

Opioid-sparing effect of cannabinoids for analgesia: an updated systematic review and meta-analysis of preclinical and clinical studies – Neuropsychopharmacology

 

Comentário no Twitter

MA of RCTs: In patients with cancer pain no effect of cannabinoid administration on opioid dose was found (MD= −3.8 mg; −10.97 to 3.37) or % change in pain scores (MD=1.84; −2.05 to 5.72) https://t.co/tTckc0z8Oz pic.twitter.com/Gh7LvYRz0n

— PfOL (@psychopharmacol) May 20, 2022

 

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Seguimento de longo prazo de estudo randomizado | Craniectomia descompressiva vs. cuidado médico padrão para pacientes com hipertensão intracraniana traumática.

16 Jun, 2022 | 14:03h

Evaluation of Outcomes Among Patients With Traumatic Intracranial Hypertension Treated With Decompressive Craniectomy vs Standard Medical Care at 24 Months: A Secondary Analysis of the RESCUEicp Randomized Clinical Trial – JAMA Neurology (gratuito por tempo limitado)

Estudo original: Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension – New England Journal of Medicine

Conteúdos relacionados:

Partial removal of skull (decompressive craniectomy) to lower treatment-resistant high pressure in the skull and brain after traumatic brain injury – Cochrane Library

Consensus statement from the International Consensus Meeting on the Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury – Acta Neurochirurgica

The Current Status of Decompressive Craniectomy in Traumatic Brain Injury – Current Trauma Reports

 

Comentário no Twitter

In this study, at 24 months, patients with posttraumatic refractory intracranial hypertension managed with a decompressive craniectomy had a sustained mortality reduction and higher rates of vegetative state, severe disability, and moderate disability. https://t.co/I8GqG885jh

— JAMA Neurology (@JAMANeuro) June 9, 2022

 

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Revisão | Fisiopatologia e mecanismo da COVID longa.

16 Jun, 2022 | 13:52h

Pathophysiology and mechanism of long COVID: a comprehensive review – Annals of Medicine

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[Preprint] Maior estudo para obter dados sobre COVID longa identifica uma ampla lista de diagnósticos.

16 Jun, 2022 | 13:51h

Comentário do estudo: Largest study to date on long COVID identifies a broad list of diagnoses – News Medical

Estudo original: Understanding Post-Acute Sequelae of SARS-CoV-2 Infection through Data-Driven Analysis with Longitudinal Electronic Health Records: Findings from the RECOVER Initiative – medRxiv

 

Comentário no Twitter

🚨 The arguably largest #LongCovid study to date with millions of participants shows the increased risk of various symptoms after infection and the risk of having to take medications. https://t.co/DSvRcKVKIs pic.twitter.com/uUQxK1VQLv

— Jonas R. Kunst (@KunstJonas) May 23, 2022

 

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Revisão ampla de metanálises de estudos observacionais prospectivos | Papel da dieta na incidência de AVC.

16 Jun, 2022 | 12:58h

Role of diet in stroke incidence: an umbrella review of meta-analyses of prospective observational studies – BMC Medicine

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História de enxaqueca está associada a maior risco de desfechos gestacionais adversos.

16 Jun, 2022 | 12:55h

Migraine History Tied to Higher Risk for Adverse Pregnancy Outcomes – HealthDay

Estudo original: Migraine and adverse pregnancy outcomes: the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be – American Journal of Obstetrics & Gynecology

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Preditores de AVC recorrente após AVC embólico de fonte indeterminada.

16 Jun, 2022 | 12:45h

Predictors of Recurrent Stroke After Embolic Stroke of Undetermined Source in the RE‐SPECT ESUS Trial – Journal of the American Heart Association

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Revisão sistemática | Produtos feitos à base de Cannabis para dor crônica.

14 Jun, 2022 | 13:24h

Cannabis-Based Products for Chronic Pain: A Systematic Review – Annals of Internal Medicine

Resumo dos anais em vídeo: Cannabis-Based Products for Chronic Pain: A Systematic Review

Resumo para pacientes: Cannabis-Based Products for Chronic Pain

Conteúdos relacionados:

Podcast: #338 LIVE! Medical Cannabis: Is it still dope? – The Curbsiders

Medicinal Cannabis for Chronic Pain: The Bermuda Triangle of Low Quality Studies, Countless Meta-analyses and Conflicting Recommendations – European Journal of Pain

RCT: Effect of medical marijuana card ownership on pain, insomnia, and affective disorder symptoms in adults.

Cohort Study: Long-term cannabis use is associated with cognitive deficits and smaller hippocampal volume in midlife.

AHA Scientific Statement | How does cannabis use affect brain health? Caution advised, more research needed.

M-A: Birth outcomes of neonates exposed to marijuana in utero.

Cannabis-related allergies: an international overview and consensus recommendations.

Review: Cannabis-based medicines and medical cannabis for chronic neuropathic pain.

Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions.

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain.

The International Cannabis Toolkit (iCannToolkit): a multidisciplinary expert consensus on minimum standards for measuring cannabis use.

Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.

Guideline: Medical cannabis or cannabinoids for chronic pain.

Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.”

NICE Guideline: Cannabis-Based Medicinal Products

Consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Short Review: Drug Interactions with Cannabinoids

Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain

Review: Considerations for cannabinoids in perioperative care by anesthesiologists.

Review: Cannabis-based Medicines and the Perioperative Physician

Study: Cannabis Use Disorder May Increase the Risk of Cardiovascular Events in Major Elective Surgeries

Perspective: If You Smoke Pot, Your Anesthesiologist Needs To Know

Perioperative Care of Cannabis Users: A Comprehensive Review of Pharmacological and Anesthetic Considerations

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Avaliação prospectiva da disfunção autonômica em pacientes com sequela pós-aguda de COVID-19.

14 Jun, 2022 | 13:18h

Prospective Evaluation of Autonomic Dysfunction in Post-Acute Sequela of COVID-19 – Journal of the American College of Cardiology

Comentário: Autonomic Dysfunction in Post-Acute Sequela of COVID-19 – American College of Cardiology

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Metanálise com dados de pacientes individuais | Indicadores prognósticos e desfechos de pacientes internados por COVID-19 com doença neurológica.

14 Jun, 2022 | 13:17h

Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis – PLOS One

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