Medicina de Família

Estudo randomizado: Entre pacientes com artrite reumatoide em remissão, a redução de DMARDs convencionais à metade da dose resultou em recorrência da doença em 25% dos pacientes, em comparação a 6% entre pacientes do grupo que manteve a dose padrão.

7 Mai, 2021 | 10:39h

Effect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial – JAMA (gratuito por tempo limitado)

Editorial: Treatment Strategies for Patients With Immune-Mediated Inflammatory Diseases – JAMA (gratuito por tempo limitado)

Comentário: Mixed Results with Refined Treatment Strategies for Rheumatic Diseases – Physician’s Weekly

Estudo de coorte: Consumo de bebidas açucaradas entre adultos e adolescentes está relacionado a aumento do risco de câncer colorretal de início precoce em mulheres.

7 Mai, 2021 | 10:21h

Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women – Gut

Comentários: Daily intake of two or more sugar-sweetened drinks associated with higher bowel cancer risk – BMJ E Expert reaction to study looking at sugary drinks intake and incidence of early-onset colorectal cancer among women – Science Media Centre

Perspectiva | A estranha ciência do efeito placebo segue cada vez mais interessante.

7 Mai, 2021 | 10:17h

The weird science of the placebo effect keeps getting more interesting – Vox

Em ação surpreendente, EUA se posiciona a favor da liberação de patentes das vacinas contra COVID. “A administração Biden atrai aplausos dos pesquisadores em saúde pública e irrita a indústria farmacêutica.”

6 Mai, 2021 | 07:49h

In shock move, US backs waiving patents on COVID vaccines – Nature

Ver também: U.S. will back proposal to waive intellectual property rights and boost Covid-19 vaccine production – STAT E Statement from the Executive Director of UNAIDS, Winnie Byanyima on the decision by the United States of America to support the TRIPS waiver for COVID-19 vaccines – UNAIDS E WHO Director-General commends United States decision to support temporary waiver on intellectual property rights for COVID-19 vaccines – World Health Organization

Comentário no Twitter

These extraordinary times and circumstances of call for extraordinary measures.

The US supports the waiver of IP protections on COVID-19 vaccines to help end the pandemic and we’ll actively participate in @WTO negotiations to make that happen. pic.twitter.com/96ERlboZS8

— Ambassador Katherine Tai (@AmbassadorTai) May 5, 2021

Estudo observacional no Catar: Vacina da Pfizer–BioNTech se mostrou 89,5% eficaz contra a variante B.1.1.7 e 75% eficaz contra a variante B.1.351. A eficácia da vacina contra doença grave, crítica ou fatal com qualquer variante do SARS-CoV-2 foi de 97,4%.

6 Mai, 2021 | 07:45h

Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants – New England Journal of Medicine

Comentário: Pfizer-BioNTech vaccine offers strong protection against key variants of concern, real-world data from Qatar shows – The Washington Post

Comentário no Twitter

📍GET BOTH DOSES! Great variants & #COVID19 vaccine news—Pfizer/BioNTech vaccine had great efficacy of 89.5% vs #B117 🇬🇧 variant & 75% vs #B1351 🇿🇦 variant for infection—but only with 2 doses. The 1 dose efficacy was just ~29% vs #B117 & ~17% vs #B1351. 🧵https://t.co/SprUfggnmh pic.twitter.com/VDWHiLsQLL

— Eric Feigl-Ding (@DrEricDing) May 6, 2021

Estudo observacional em Israel: vacina da Pfizer-BioNTech é 95,3% eficaz contra a infecção por SARS-CoV-2.

6 Mai, 2021 | 07:43h

Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data – The Lancet

Comentários: Expert reaction to Israel nation-wide study looking at Pfizer vaccine effectiveness – Science Media Centre E Covid-19: Two doses of Pfizer vaccine are “highly effective” against infection, hospital admission, and death, study finds – The BMJ

Mudança na prática | Um regime de 4 meses de rifapentina com moxifloxacina não é inferior ao regime padrão de 6 meses no tratamento da tuberculose.

6 Mai, 2021 | 07:34h

Four-Month Rifapentine Regimens with or without Moxifloxacin for Tuberculosis – New England Journal of Medicine

Comentário: Four-month TB treatment matches six-month standard of care – Aidsmap

Estudo randomizado: A combinação de liraglutida + exercícios melhora a manutenção da perda de peso, mais do que cada tratamento isoladamente.

6 Mai, 2021 | 07:30h

Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined – New England Journal of Medicine

Comentário: Liraglutide beneficial for post-diet weight loss maintenance – Medwire News

Diretriz: Diagnóstico e tratamento da disfagia neurogênica.

6 Mai, 2021 | 07:28h

Diagnosis and treatment of neurogenic dysphagia – S1 guideline of the German Society of Neurology – Neurological Research and Practice

Revisão: Diagnóstico e tratamento da angina estável.

6 Mai, 2021 | 07:26h

Diagnosis and Management of Stable Angina: A Review – JAMA (gratuito por tempo limitado)

Podcast: Chronic Stable Angina—Diagnosis and Treatment – JAMA