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Acesso livre

Medicina de Emergências

Estudo randomizado PRINCIPLE | Doxiciclina não melhora os desfechos de pacientes ambulatoriais com suspeita de COVID-19.

2 Ago, 2021 | 17:44h

Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial – The Lancet Respiratory Medicine

Comentário: PRINCIPLE: a community-based COVID-19 platform trial – The Lancet Respiratory Medicine

 

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Análise das evidências | Piperacilina-tazobactam é segura em pacientes alérgicos à penicilina?

2 Ago, 2021 | 17:20h

Is piperacillin-tazobactam safe in patients with penicillin allergy? – PulmCrit

COVID-19 e mucormicose: a tempestade perfeita.

2 Ago, 2021 | 16:56h

COVID-19 and mucormycosis superinfection: the perfect storm – Infection

Conteúdos relacionados:

ECMM/ISHAM recommendations for clinical management of COVID -19 associated mucormycosis in low- and middle-income countries.

The “Black Fungus” in India: The Emerging Syndemic of COVID-19–Associated Mucormycosis – careful use of antibiotics and corticosteroids and closely monitoring blood glucose levels are some of the strategies suggested by the authors.

Multicenter Epidemiologic Study of Coronavirus Disease–Associated Mucormycosis, India – Uncontrolled diabetes mellitus was the most common underlying disease; improper glucocorticoid use was independently associated with the disease.

Opinion | “Doctors have been blamed for the rise in black fungus in India, but the COVID treatment guidelines could be contributing” – improper use of antibiotics and higher than usual doses of corticosteroids may be contributing to the emergence of mucormycosis and other fungal co-infections.

What is mucormycosis, the fungal infection affecting COVID patients in India?

[Preprint] The Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries.

Mucormycosis: The ‘black fungus’ maiming Covid patients in India

Global Guideline for the Diagnosis and Management of Mucormycosis

Estudo randomizado | Antibioticoterapia por 7 dias é tão boa quanto por 14 dias para homens com infecção de trato urinário que estejam sem febre.

2 Ago, 2021 | 16:51h

Effect of 7 vs 14 Days of Antibiotic Therapy on Resolution of Symptoms Among Afebrile Men With Urinary Tract Infection: A Randomized Clinical Trial – JAMA (gratuito por tempo limitado)

Editorial: Shorter Courses of Antibiotics for Urinary Tract Infection in Men (gratuito por tempo limitado)

Comentário: Study Supports Shorter Antibiotic Course for Afebrile Men With UTI – MPR

 

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Relatório do CDC | Transmissão de Candida auris pan-resistente em instituições de cuidados em saúde.

2 Ago, 2021 | 16:46h

Notes from the Field: Transmission of Pan-Resistant and Echinocandin-Resistant Candida auris in Health Care Facilities ― Texas and the District of Columbia, January–April 2021 – CDC Morbidity and Mortality Weekly Report

Comentários:

CDC reports two outbreaks of pan-resistant Candida auris – CIDRAP

U.S. sees first cases of dangerous fungus resistant to all drugs in untreated people – STAT

Conteúdos relacionados:

Case reports: Multidrug-resistant Candida auris infections in critically ill Covid-19 patients

Candida auris: A Review of Recommendations for Detection and Control in Healthcare Settings

Global Epidemiology of Emerging Candida Auris (revisões e comentários sobre o tema)

The superbug Candida auris is giving rise to warnings — and big questions – STAT

Candida Auris – “A Mysterious Infection, Spanning the Globe in a Climate of Secrecy” (revisões e comentários sobre o tema)

 

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Diretriz NICE | Infecção por Clostridioides difficile infection: prescrição de antibióticos.

27 Jul, 2021 | 10:22h

Clostridioides difficile infection: antimicrobial prescribing – National Institute for Health and Care Excellence

Infográfico: Clostridioides difficile infection: antimicrobial prescribing

Conteúdos Relacionados:

IDSA 2021 focused update guidelines on the management of Clostridioides difficile infection in adults.

ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections.

Prevention of Clostridioides difficile in hospitals: A position paper of the International Society for Infectious Diseases

Review | My Treatment Approach to Clostridioides difficile Infection.

[Preprint] RCT: Em pacientes com COVID-19 e hipóxia grave, a dexametasona 12 mg NÃO resultou em melhora estatisticamente significativa nos desfechos em comparação com a dexametasona 6 mg – “A mortalidade em 28 dias foi de 27,1% e 32,3% em pacientes atribuídos a 12 mg e 6 mg, respectivamente (risco relativo ajustado 0,86, 99% IC, 0,68-1,08).”

26 Jul, 2021 | 10:24h

Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxia: an international, randomized, blinded trial – medRxiv

Estudo mostra que o teste de antígeno de fluxo lateral pode detectar, de modo rápido e acurado, a COVID-19 inicial em pacientes com sintomas gripais e pode ser uma alternativa plausível ao RT-PCR.

26 Jul, 2021 | 10:19h

Comparing the diagnostic accuracy of point-of-care lateral flow antigen testing for SARS-CoV-2 with RT-PCR in primary care (REAP-2) – EClinicalMedicine

Comunicado de imprensa: Lateral flow tests are 95% effective at detecting Covid-19 when used at the onset of symptoms – University of Oxford

Relacionado:

Interactive Infographic | Interpreting a lateral flow SARS-CoV-2 antigen test – “This calculator demonstrates how interpreting a covid-19 lateral flow device (LFD) result varies according to the pre-test probability, and the sensitivity and specificity of the LFD used”.

Rapid point-of-care tests for diagnosing COVID-19 infection: the latest Cochrane evidence

 

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Relato de caso | Síndrome inflamatória multissistêmica similar a doença de Kawasaki associada a infecção por SARS-CoV-2 em adulto.

26 Jul, 2021 | 10:16h

Kawasaki-like multisystem inflammatory syndrome associated with SARS-CoV-2 infection in an adult – BMJ Case Reports

Relacionado:

Case report: Multisystem inflammatory syndrome in an adult after SARS-CoV-2 infection.

Characteristics associated with Multisystem Inflammatory Syndrome among adults with SARS-CoV-2 infection

Case series of multisystem inflammatory syndrome in adults associated with SARS-CoV-2 infection

Case Reports: 2 Adults with Kawasaki-like Multisystem Inflammatory Syndrome Associated with COVID-19

Revisão | Momento e conclusão da revascularização em síndromes coronárias agudas.

26 Jul, 2021 | 10:02h

Timing and completeness of revascularisation in acute coronary syndromes – Heart

 

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