Interesse Geral

Subnotificação de mortes limita a compreensão sobre o verdadeiro impacto da Covid-19.

29 Out, 2021 | 14:54h

Under-reporting of deaths limits our understanding of true burden of covid-19 – The BMJ

Conteúdos relacionados:

Study shows COVID-19 has caused the biggest decrease in life expectancy since World War II.

Just how do deaths due to COVID-19 stack up?

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.

Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.

Report: Three new estimates of India’s all-cause excess mortality during the COVID-19 Pandemic – pandemic death toll estimated to be between 3.4 million and 4.9 million excess deaths.

COVID-19 has caused 6.9 million deaths globally, more than double what official reports show

 

Comentário no Twitter

Mortality data have been essential in understanding the spread of covid-19 and navigating the trade-offs that underlie political decision making, yet under-reporting in official death records has greatly obscured this understanding.

What should be done?https://t.co/pI8aVpa3NR

— The BMJ (@bmj_latest) October 14, 2021

 

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Nove palavras pandêmicas que poucos acertam como utilizar.

29 Out, 2021 | 14:50h

Nine Pandemic Words That Almost No One Gets Right – The Atlantic

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Merck autoriza que outros países produzam novo antiviral contra COVID-19.

28 Out, 2021 | 16:17h

Merck to allow other nations to produce new COVID-19 antiviral – CIDRAP

Ver também:

Merck will allow drugmakers in other countries to make its COVID-19 pill – NPR

Game-Changing COVID-19 Oral Treatment Set To Become Widely Accessible in Low- and Middle-Income Countries Upon Regulatory Approval – Health Policy Watch

Conteúdos relacionados:

Video: Merck’s Covid pill could transform treatment. Here’s how it works.

How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.

What we know — and don’t know — about Merck’s new Covid-19 pill.

[Press release – not published yet] Merck announces oral antiviral Molnupiravir reduced the risk of hospitalization or death by approximately 50 Percent compared to placebo for patients with mild or moderate COVID-19.

Merck’s Covid-19 pill is great news but may not be a game-changer.

Video | A Pill For COVID? A Doctor Explains Molnupiravir.

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Dois estudos observacionais levantam dúvidas sobre os efeitos do fechamento de escolas na redução da transmissão da Covid-19.

28 Out, 2021 | 16:15h

Estudo 1: No causal effect of school closures in Japan on the spread of COVID-19 in spring 2020 – Nature Medicine

Estudo 2: The impact of school opening model on SARS-CoV-2 community incidence and mortality – Nature Medicine

 

Comentários no Twitter

Results from a study in the US published in @NatureMedicine indicate that schools can reopen for in-person learning without substantially increasing community case rates of SARS-CoV-2. However, the impacts are variable and more study is needed. https://t.co/NFt1vNNb76 pic.twitter.com/fNgsJn6WLg

— Nature Portfolio (@NaturePortfolio) October 27, 2021

(fio – clique para saber mais)

2 new @NatureMedicine papers
First from half of US public school data
"Schools can open for in-person learning during the pandemic with minimal contribution to sustained community incidence of infections, provided other public safety measures are adopted."https://t.co/gn8MzrYVxE pic.twitter.com/qGfQLMzDEW

— Eric Topol (@EricTopol) October 27, 2021

 

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O que as vacinas contra COVID em crianças mais novas podem significar para a pandemia.

28 Out, 2021 | 16:14h

What COVID vaccines for young kids could mean for the pandemic – Nature

Conteúdo relacionado: FDA advisory panel recommends Pfizer Covid-19 vaccine be authorized for children ages 5 to 11.

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Painel consultivo do FDA recomenda que a vacina da Pfizer contra a Covid-19 seja autorizada para crianças de 5 a 11 anos de idade.

27 Out, 2021 | 12:44h

FDA advisory panel recommends Pfizer Covid-19 vaccine be authorized for children – STAT

Ver também:

Tracking the FDA advisory panel meeting on Covid-19 vaccines for kids – STAT

FDA advisory panel recommends Pfizer vaccine for kids ages 5 to 11 – NPR

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Vacinação heteróloga AstraZeneca/Pfizer parece estar associada com maior efetividade contra Covid-19 em comparação com a vacinação homóloga Pfizer/Pfizer.

27 Out, 2021 | 12:41h

Immunogenicity and efficacy of heterologous ChadOx1/BNT162b2 vaccination – Nature

Conteúdos relacionados:

Cohort Study: The effectiveness of heterologous AstraZeneca (AZ)/mRNA prime-boost vaccination was more significant (68%) compared to the effectiveness of homologous AZ/AZ vaccination (50%) against symptomatic Covid-19 infection in Sweden.

Should You Mix and Match Your Booster Shot?

Study evaluated several heterologous SARS-CoV-2 vaccine regimens; no efficacy data but there was increased antibody production on study days 15 and 29 after booster shots from Moderna and Pfizer.

A primer on what we know about mixing and matching Covid vaccines.

Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination.

RCT: Safety and immunogenicity of heterologous vs. homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine.

Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.

Heterologous Oxford–AstraZeneca and Moderna Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

Heterologous Oxford–AstraZeneca and BioNTech/Pfizer Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

[Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”.

Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”.

Lab study shows heterologous AstraZeneca/Pfizer vaccination produces strong immune response against SARS-CoV-2 Delta variant.

Lab study shows a heterologous AstraZeneca + Pfizer immunization strategy provides stronger immunogenicity against Covid compared to homologous AZ + AZ or Pfizer + Pfizer strategies.

RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.

 

Comentário no Twitter

A dose of the AstraZeneca COVID-19 vaccine followed by a dose of the Pfizer/BioNTech vaccine confers better protection against SARS-CoV-2 infection than two doses of the Pfizer vaccine, according to a study in healthcare workers published in @Nature. https://t.co/6hIVkiOLQ1 pic.twitter.com/AmsyVUMpoj

— Nature Portfolio (@NaturePortfolio) October 26, 2021

 

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Bioética | A sugestão de que os negacionistas da Covid fiquem longe dos hospitais públicos da Austrália é terrível.

27 Out, 2021 | 13:21h

The suggestion Covid deniers should stay out of Australian public hospitals is appalling – The Guardian

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COVID: qual deve ser o nível de preocupação quanto à nova linhagem AY.4.2 do coronavírus?

26 Out, 2021 | 11:31h

COVID: how worried should we be about the new AY.4.2 lineage of the coronavirus? – The Conversation

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O que significa estar totalmente vacinado.

26 Out, 2021 | 11:28h

What It Means To Be Fully Vaccinated – Think Global Health

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