Infectologia

Extensão do alcance da gestão de antibióticos para pacientes pediátricos.

10 Mar, 2022 | 15:19h

Extending the Reach of Antimicrobial Stewardship to Pediatric Patients – Infectious Diseases and Therapy

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Segurança e eficácia do de-escalonamento e descontinuação de antibióticos em pacientes hematológicos de alto risco com neutropenia febril: experiência de centro único.

10 Mar, 2022 | 15:17h

Safety and Efficacy of Antibiotic De-escalation and Discontinuation in High-Risk Hematological Patients With Febrile Neutropenia: A Single-Center Experience – Open Forum Infectious Diseases

Conteúdo relacionado: Management of febrile neutropaenia: ESMO Clinical Practice Guidelines – Annals of Oncology

 

Comentário no Twitter

OFID: In high-risk hematological patients w/ febrile neutropenia, antibiotic de-escalation and discontinuation prior to neutrophil recovery did not lead to an increase in infectious complications. https://t.co/eUer1fmoc6 #IDSAJournals @PaulSaxMD @DrJLi @FungalDoc @jobadd pic.twitter.com/HuGRYA8YW3

— IDSA (@IDSAInfo) January 5, 2022

 

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SARS-CoV-2 levou a alterações na estrutura cerebral em pacientes do Biobank do Reino Unido.

9 Mar, 2022 | 13:48h

SARS-CoV-2 is associated with changes in brain structure in UK Biobank – Nature

Comentários:

Brain changes after COVID revealed by imaging – Nature

Even mild cases of COVID-19 can leave a mark on the brain, such as reductions in gray matter – a neuroscientist explains emerging research – The Conversation

Scans reveal how Covid may change the brain – BBC

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Estudo de coorte | Trajetória de 1 ano das alterações cognitivas em sobreviventes idosos da COVID-19 em Wuhan, na China.

9 Mar, 2022 | 13:46h

One-Year Trajectory of Cognitive Changes in Older Survivors of COVID-19 in Wuhan, China: A Longitudinal Cohort Study – JAMA Neurology

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OMS afirma que doses de reforço da vacina contra COVID são necessárias, revertendo recomendação anterior.

9 Mar, 2022 | 13:45h

WHO says COVID boosters needed, reversing previous call – Associated Press

 

Comentário no Twitter

Who needs a booster? The @WHO reverses its position and supports "urgent and broad" 3-shot vaccination https://t.co/y5pyY9bJr7 @AP The evidence has supported that move for several months.
"Fully vaccinated" = 3-shots
(or confirmed infection-acquired immunity + 1 shot)

— Eric Topol (@EricTopol) March 8, 2022

 

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Segurança das vacinas de mRNA administradas durante os primeiros 6 meses no programa de vacinação contra COVID-19 dos EUA.

9 Mar, 2022 | 13:44h

Safety of mRNA vaccines administered during the initial 6 months of the US COVID-19 vaccination programme: an observational study of reports to the Vaccine Adverse Event Reporting System and v-safe – The Lancet Infectious Diseases

Comentários:

Large US study confirms most mRNA COVID-19 vaccine side effects are mild and temporary – Lancet

Covid vaccines not linked to deaths, major US study finds – BBC

Most mRNA COVID vaccine adverse events mild, transient – CIDRAP

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Diretriz IDSA sobre o tratamento de infecções por Gram-negativos antibioticorresistentes – Foco nas enterobactérias produtoras de betalactamase de espectro estendido, enterobactérias resistentes a carbapeném e Pseudomonas aeruginosa resistente e difícil de tratar.

9 Mar, 2022 | 13:42h

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 1.0 – Infectious Diseases Society of America

Conteúdos relacionados:

Therapeutic Strategies for Emerging Multidrug-Resistant Pseudomonas aeruginosa – Infectious Diseases and Therapy

IDSA guidance and ESCMID guidelines: complementary approaches toward a care standard for MDR Gram-negative infections – Clinical Microbiology and Infection

European guidelines for the treatment of infections caused by Multidrug-resistant Gram-negative bacilli.

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections.

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Revisão com imagens | Tuberculose extrapulmonar: um problema antigo, mas que sempre ressurge.

9 Mar, 2022 | 13:27h

Extrapulmonary tuberculosıs: an old but resurgent problem – Insights into Imaging

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Estudo randomizado | Azitromicina não é efetiva na prevenção de sibilo recorrente após bronquiolite grave causada por vírus sincicial respiratório.

8 Mar, 2022 | 18:40h

Azithromycin to Prevent Recurrent Wheeze Following Severe Respiratory Syncytial Virus Bronchiolitis – NEJM Evidence

Comentários:

Study finds azithromycin use during RSV not useful in preventing recurrent wheezing, may cause harm – Vanderbilt University Medical Center

Antibiotic doesn’t prevent future wheezing in babies hospitalized with RSV – Washington University in St. Louis

 

Comentário no Twitter

This RCT tested oral azithromycin vs placebo to reduce recurrent wheeze (RW) in 1-18-month-olds hospitalized with acute severe RSV bronchiolitis. Azithromycin did not reduce occurrence of RW and may increase risk of RW in some groups. #AAAAI22 #Asthma #EBM https://t.co/jYcBuiQ8aY pic.twitter.com/u65NbQaIlX

— NEJM Evidence (@NEJMEvidence) February 28, 2022

 

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Estudo mostra que o número de infecções por Covid-19 não identificadas por testes de fluxo lateral é “substancial o bastante para ter importância clínica.”

8 Mar, 2022 | 18:36h

Comunicado de imprensa: Number of covid-19 infections missed by lateral flow tests “substantial enough to be of clinical importance,” warn experts – BMJ

Estudo original: SARS-CoV-2 antigen lateral flow tests for detecting infectious people: linked data analysis – The BMJ

Comentários:

Lateral flow tests may be missing ‘substantial’ number of COVID-19 infections – Imperial College London

Self-testing for asymptomatic non-contacts using rapid antigen tests—is this leading to a cost effective reduction in infection transmission? – The BMJ

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