Infectologia
Estudo randomizado | Efeito da posição prona na entubação endotraqueal de pacientes com COVID-19 e insuficiência respiratória aguda.
17 Mai, 2022 | 12:13hConteúdos relacionados:
RCT: Prone positioning of patients with moderate hypoxia due to COVID-19 – medRxiv
Comentário no Twitter
In this trial, in patients with acute hypoxemic respiratory failure from #COVID19, prone positioning, compared with usual care without prone positioning, did not significantly reduce endotracheal intubation at 30 days. https://t.co/1RyYRtcrYj
— JAMA (@JAMA_current) May 15, 2022
Estudo randomizado | Comparação de antibioticoterapia por 8 vs. 15 dias para pneumonia por Pseudomonas aeruginosa associada a ventilador mecânico em adultos.
17 Mai, 2022 | 12:07hComparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial – Intensive Care Medicine (artigo gratuito aqui)
Comentário no Twitter
🧫 8 vs 15 days ABT for Pseudomonas aeruginosa VAP in adults, iDIAPASON RCT: no differences in composite or separate outcomes (90-day mortality/VAP recurrence) between short & long duration treatment.
📢 @yourICM ground-breaking release #LIVES40 #FOAMcc
🖇 https://t.co/LfoUWxCkkl pic.twitter.com/XaWkQ5R6wT— Intensive Care Medicine (@yourICM) May 13, 2022
Estudo de caso-controle e teste negativo | Associação entre vacinação prévia com BNT162b2 contra COVID-19 e infecção sintomática por SARS-CoV-2 em crianças e adolescentes durante a predominância da variante Ômicron.
17 Mai, 2022 | 12:04hEstudo relacionado: Risk of Infection and Hospitalization Among Vaccinated and Unvaccinated Children and Adolescents in New York After the Emergence of the Omicron Variant – JAMA
Editorial: Protecting Children Against Omicron – JAMA
Comentário no Twitter (fio – clique para saber mais)
This new JAMA study is worth discussing. It found that, this winter, vax effectiveness in 12-15 yos dropped to 0% after 3-5 months & vaccinated were MORE likely to test+ at month 7. May be confounded (see🧵)
But I don't see this as good reason for boostershttps://t.co/zpkIDdZhnn pic.twitter.com/bxAIDmiR8s— Tracy Høeg, MD, PhD (@TracyBethHoeg) May 14, 2022
Hipótese | Hepatite aguda grave em crianças: investigação dos superantígenos do SARS-CoV-2.
17 Mai, 2022 | 12:03hConteúdos relacionados:
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Comentário no Twitter
A solid hypothesis for the basis of the mysterious, severe acute hepatitis in children: superantigen formation from prior Covid viral reservoir in the GI tract with superimposed adenovirus infection https://t.co/1eehyQmlhi @LancetGastroHep pic.twitter.com/UqCAh3igMH
— Eric Topol (@EricTopol) May 14, 2022
Diagnóstico molecular na pneumonia grave: um novo começo ou uma falsa promessa?
17 Mai, 2022 | 11:46hMolecular diagnostics in severe pneumonia: a new dawn or false promise? – Intensive Care Medicine
Comentário no Twitter
Pneumonia? no gold standard diagnosis available, likely resulting in overtreatment. Molecular diagnostics more widely available even if interpretation/use complex, requiring to take into account data/characteristics when making decisions based on these.
📎 https://t.co/mae0vxBfkF pic.twitter.com/bbkxGLEumN— Intensive Care Medicine (@yourICM) May 14, 2022
Profilaxia oral pré-exposição (PrEP) para evitar infecção pelo HIV: revisão sistemática e metanálise de efetividade clínica, segurança, adesão e compensação de risco em todas as populações.
17 Mai, 2022 | 11:43hExplicando a hepatite inexplicada em crianças.
16 Mai, 2022 | 16:49hExplaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Conteúdos relacionados:
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Novas versões da variante Ômicron são mestres da evasão imunológica.
16 Mai, 2022 | 16:47hNew versions of Omicron are masters of immune evasion – Science
Comentário no Twitter
"Based on its immunological profile, it [Omicron & its subvariants] should be called SARS-3"https://t.co/zxV3T2SKIB@gretchenvogel @NewsfromScience
w/ @K_G_Andersen @Tuliodna @linfa_wang pic.twitter.com/ToKDqNGH74— Eric Topol (@EricTopol) May 12, 2022