Infectologia

Série de casos | Surto de hepatite em crianças: curso clínico de crianças com insuficiência hepática aguda admitidas em UTI.

19 Jun, 2022 | 13:40h

Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit – Intensive Care Medicine (se o acesso a este link for pago, tente este)

Conteúdo relacionado: Investigating acute hepatitis of unknown origin in children (várias fontes sobre o tema)

 

Comentário no Twitter

Outbreak of non-A-E hepatitis in children, 🇬🇧 data. Good outcomes if ALF by dedicated liver #ICU with early referral to Tx centres, recognizing neuro-deterioration, high-volume #ECLS, close neuromonitoring/protection & support by hepatology/Tx physicians
📎https://t.co/GYAMaZbVGD pic.twitter.com/GA58vJWQIz

— Intensive Care Medicine (@yourICM) June 10, 2022

 

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Diretriz atualizada NIH | Oxigenação e ventilação para adultos com Covid-19.

19 Jun, 2022 | 13:37h

Oxygenation and Ventilation for Adults – National Institutes of Health

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M-A | Coinfecções respiratórias virais em pacientes com COVID-19 e desfechos associados.

19 Jun, 2022 | 13:34h

Respiratory viral co-infections in patients with COVID-19 and associated outcomes: A systematic review and meta-analysis – Reviews in Medical Virology

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Estudo randomizado | Tixagevimabe-cilgavimabe intramuscular pode ser benéfico para adultos não vacinados e não internados com Covid-19.

19 Jun, 2022 | 13:33h

Efficacy and safety of intramuscular administration of tixagevimab–cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trial – The Lancet Respiratory Medicine

Comentários:

Safety and efficacy of tixagevimab–cilgavimab in preventing severe COVID – News Medical

Expert reaction to results of the TACKLE Phase 3 trial of Evusheld (tixagevimab and cilgavimab) for treating early COVID-19 in outpatients – Science Media Centre

 

Comentário no Twitter

NEW—A single intramuscular tixagevimab–cilgavimab dose provided protection against progression to severe COVID-19 or death vs placebo in unvaccinated individuals

TACKLE trial from Prof Hugh Montgomery & colleagues https://t.co/M9LENFsA2C pic.twitter.com/Aon4wJsBOi

— The Lancet Respiratory Medicine (@LancetRespirMed) June 8, 2022

 

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Imunoterapia direcionada ao hospedeiro para infecções virais e bacterianas: passado, presente e futuro.

19 Jun, 2022 | 13:07h

Host-directed immunotherapy of viral and bacterial infections: past, present and future – Nature Reviews Immunology (se o acesso a este link for pago, tente este no PMC)

 

Comentário no Twitter

A Perspective in @NatRevImmunol reflects on the historical development of host-directed immunotherapeutic interventions for infections and how historical insights can be used in the therapy of SARS-CoV-2 and Mycobacterium tuberculosis infections. https://t.co/5WOXzePpFS pic.twitter.com/dpj1XNi2me

— Nature Portfolio (@NaturePortfolio) June 11, 2022

 

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Outro estudo sugere que a variante Ômicron está associada com risco reduzido de síndrome inflamatória multissistêmica em crianças em comparação a variantes anteriores do SARS-CoV-2.

16 Jun, 2022 | 14:01h

Risk and Phenotype of Multisystem Inflammatory Syndrome in Vaccinated and Unvaccinated Danish Children Before and During the Omicron Wave – JAMA Pediatrics

Estudo relacionado: Severity and Incidence of Multisystem Inflammatory Syndrome in Children During 3 SARS-CoV-2 Pandemic Waves in Israel – JAMA E Commentary: Kids’ COVID syndrome—MIS-C—less severe in Omicron – CIDRAP

 

Comentário no Twitter

Study found that the risk of multisystem inflammatory syndrome in children (MIS-C) following SARS-CoV-2 infection during the #Omicron wave substantially lower compared to previous #SARSCoV2 variants. https://t.co/GYrz9XA72Z

— JAMA Pediatrics (@JAMAPediatrics) June 8, 2022

 

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Estudo de coorte | Desfechos de neurodesenvolvimento em 1 ano em bebês de mães com teste positivo para SARS-CoV-2 durante a gestação.

16 Jun, 2022 | 13:58h

Neurodevelopmental Outcomes at 1 Year in Infants of Mothers Who Tested Positive for SARS-CoV-2 During Pregnancy – JAMA Network Open

Comentários:

Is It Exposure to the Pandemic or to Maternal SARS-CoV-2 Infection That Is Adversely Affecting Early Childhood Neurodevelopment? – JAMA Network Open

Expert reaction to observational study of mothers who tested positive for SARS-CoV-2 during pregnancy and neurodevelopmental outcomes in their children at 1 year – Science Media Centre

 

Comentário no Twitter

This cohort study of #SARSCoV2 exposure in utero found preliminary evidence that maternal SARS-CoV-2 may be associated with neurodevelopmental sequelae in some offspring. https://t.co/dYdoJbNOdl

— JAMA Network Open (@JAMANetworkOpen) June 9, 2022

 

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M-A | Ocorrência e potencial de transmissão de infecções por SARS-CoV-2 assintomáticas e pré-sintomáticas.

16 Jun, 2022 | 13:55h

Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: Update of a living systematic review and meta-analysis – PLOS Medicine

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Diretriz | Triagem e momento cirúrgicos em pacientes com COVID submetidos a cirurgia torácica.

16 Jun, 2022 | 13:54h

Surgical Triage and Timing for Patients with COVID: A Guidance Statement from the Society of Thoracic Surgeons – Annals of Thoracic Surgery

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Revisão | Fisiopatologia e mecanismo da COVID longa.

16 Jun, 2022 | 13:52h

Pathophysiology and mechanism of long COVID: a comprehensive review – Annals of Medicine

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