Infectologia

M-A | Não é seguro restringir o uso de antibióticos nas infecções de trato urinário não complicadas em mulheres adultas.

8 Jul, 2022 | 11:17h

Reducing antibiotic use in uncomplicated urinary tract infections in adult women: a systematic review and individual participant data meta-analysis – Clinical Microbiology and Infection

 

Comentário no Twitter (fio – clique para saber mais)

A really important analysis of previous trials!

1/ All short-term outcomes were worse for women given non-antibiotic strategies, including need for future antibiotics (number needed to harm=5!) https://t.co/iozelljFLk

— Annie Joseph (@ajosephnotts) July 2, 2022

 

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Revisão | Tuberculose na cirrose – Um dilema de diagnóstico e tratamento.

8 Jul, 2022 | 10:58h

Tuberculosis in Cirrhosis – A Diagnostic and Management Conundrum – Journal of Clinical and Experimental Hepatology

 

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M-A | Efetividade de intervenções que visam a melhorar a água potável, o saneamento e a lavagem de mãos com sabão sobre o risco de doença diarreica em crianças em países de média e baixa rendas.

7 Jul, 2022 | 12:26h

Effectiveness of interventions to improve drinking water, sanitation, and handwashing with soap on risk of diarrhoeal disease in children in low-income and middle-income settings: a systematic review and meta-analysis – The Lancet

 

Comentário no Twitter

WASH meta-analysis in @TheLancet

Effectiveness of WASH interventions on child diarrhoea in LMICshttps://t.co/yVtoyattQd

How effective are
– water supply (by level of service)
– POU water treatment (by type)
– sanitation (by LoS)
– handwashing with soap

Read to find out!

— Environmental Health Group, LSHTM (@LSHTM_EHG) July 1, 2022

 

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Estudo randomizado | Alta dose de dexametasona e estratégias de suporte de oxigênio em pacientes na UTI com insuficiência respiratória hipoxêmica aguda grave por COVID-19.

7 Jul, 2022 | 12:23h

High-Dose Dexamethasone and Oxygen Support Strategies in Intensive Care Unit Patients With Severe COVID-19 Acute Hypoxemic Respiratory Failure: The COVIDICUS Randomized Clinical Trial – JAMA Internal Medicine

 

Comentário no Twitter

In this RCT, high-dose dexamethasone did not significantly improve the 60-day survival. The oxygenation strategy in initially non-intubated patients did not significantly modify the 28-day risk of invasive mechanical ventilation requirement. https://t.co/ZNajW2KBKR

— JAMA Internal Medicine (@JAMAInternalMed) July 5, 2022

 

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Revisão | O momento de hesitação da vacina.

7 Jul, 2022 | 12:21h

The Vaccine-Hesitant Moment – New England Journal of Medicine

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Riscos específicos relacionados a idade e sexo para miocardite e pericardite após vacinação contra Covid-19 com vacinas de RNA mensageiro.

7 Jul, 2022 | 12:20h

Age and sex-specific risks of myocarditis and pericarditis following Covid-19 messenger RNA vaccines – Nature Communications

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Estudo randomizado | Teste dos efeitos da combinação de azitromicina com tobramicina inalatória para P. aeruginosa na fibrose cística.

7 Jul, 2022 | 12:07h

Testing the effects of combining azithromycin with inhaled tobramycin for P. aeruginosa in cystic fibrosis: a randomised, controlled clinical trial – Thorax

Comentário: Does Azithromycin antagonize the effect of inhaled tobramycin in cystic fibrosis? – Medical Dialogues

 

Comentário no Twitter

Original research: Testing the effects of combining azithromycin with inhaled tobramycin for P. aeruginosa in cystic fibrosis: a randomised, controlled clinical trialhttps://t.co/z9dGX52dAe pic.twitter.com/tpiOqIIQjb

— ThoraxBMJ (@ThoraxBMJ) May 23, 2022

 

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Diretrizes OMS para diagnóstico, prevenção e tratamento da doença criptocócica entre adultos, adolescentes e crianças vivendo com HIV.

6 Jul, 2022 | 11:29h

Guidelines for diagnosing, preventing and managing cryptococcal disease among adults, adolescents and children living with HIV – World Health Organization

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Diretriz OMS para tratamento de leishmaniose visceral em pacientes coinfectados pelo HIV no leste africano e no sudeste asiático.

6 Jul, 2022 | 11:28h

WHO guideline for the treatment of visceral leishmaniasis in HIV co-infected patients in East Africa and South-East Asia – World Health Organization

Comunicado de imprensa: Visceral leishmaniasis and HIV coinfection: WHO publishes new guideline with region-specific treatment recommendations – World Health Organization

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Insuficiência hepática pediátrica indeterminada: características clínicas de um cluster temporal de 5 crianças na Holanda durante a primavera de 2022.

6 Jul, 2022 | 11:16h

Indeterminate pediatric acute liver failure: Clinical characteristics of a temporal cluster of five children in the Netherlands in the spring of 2022 – UEG Journal

Conteúdos relacionados:

Sudden onset hepatitis in children – Nature Reviews Gastroenterology & Hepatology (se o acesso a este link for pago, tente este)

Severe acute hepatitis of unknown aetiology in children – Multi-country – World Health Organization

Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit – Intensive Care Medicine (se o acesso a este link for pago, tente este)

Investigating Acute Hepatitis of Unknown Origin in Children – American Society for Microbiology

What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both? – Science

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing 3 – UK Health Security Agency

Case numbers of acute hepatitis of unknown aetiology among children in 24 countries up to 18 April 2022 compared to the previous 5 years – Eurosurveillance

Severe acute hepatitis and acute liver failure of unknown origin in children: a questionnaire-based study within 34 paediatric liver centres in 22 European countries and Israel, April 2022 – Eurosurveillance

Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens – The Lancet Gastroenterology & Hepatology

Puzzling pediatric hepatitis cases echo an earlier mysterious illness – STAT

Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC

Hepatitis outbreak in children: What do we know so far? – Imperial College London

Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases

Epidemiological update: Hepatitis of unknown aetiology in children – European Centre for Disease Prevention and Control

Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing 2 – UK Health Security Agency

With usual suspects ruled out, disease detectives try to crack mystery of viral hepatitis cases in kids – STAT

Acute Hepatitis and Adenovirus Infection Among Children — Alabama, October 2021–February 2022 – Morbidity and Mortality Weekly Report

The CDC and WHO Have Reported an Unusual Cluster of Severe Pediatric Hepatitis Cases – Science-Based Medicine

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing – UK Health Security Agency

Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization

WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT

CDC Alerts Providers to Hepatitis Cases of Unknown Origin – Centers for Disease Control and Prevention

Recommendations for Adenovirus Testing and Reporting of Children with Acute Hepatitis of Unknown Etiology – Centers for Disease Control and Prevention

Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch

Increase in hepatitis (liver inflammation) cases in children under investigation – UK Health Security Agency

U.S., U.K. investigating unusual cases of hepatitis in young children – STAT

Acute hepatitis of unknown aetiology – the United Kingdom of Great Britain and Northern Ireland – World Health Organization

Increase in acute hepatitis of unknown origin among children – United Kingdom – European Centre for Disease Prevention and Control

Mysterious liver illness seen in kids in US, Europe – Associated Press

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