Acesso livre
Acesso livre

Infectologia

Diferentes vacinas contra COVID misturadas e combinadas com sucesso no teste de efetividade – “Não é preciso se restringir a nenhuma marca.”

27 Out, 2021 | 12:39h

Mix-and-match COVID vaccines ace the effectiveness test – Nature

Conteúdos relacionados:

Cohort Study: The effectiveness of heterologous AstraZeneca (AZ)/mRNA prime-boost vaccination was more significant (68%) compared to the effectiveness of homologous AZ/AZ vaccination (50%) against symptomatic Covid-19 infection in Sweden.

Should You Mix and Match Your Booster Shot?

Study evaluated several heterologous SARS-CoV-2 vaccine regimens; no efficacy data but there was increased antibody production on study days 15 and 29 after booster shots from Moderna and Pfizer.

A primer on what we know about mixing and matching Covid vaccines.

Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination.

RCT: Safety and immunogenicity of heterologous vs. homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine.

Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.

Heterologous Oxford–AstraZeneca and Moderna Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

Heterologous Oxford–AstraZeneca and BioNTech/Pfizer Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

[Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”.

Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”.

Lab study shows heterologous AstraZeneca/Pfizer vaccination produces strong immune response against SARS-CoV-2 Delta variant.

Lab study shows a heterologous AstraZeneca + Pfizer immunization strategy provides stronger immunogenicity against Covid compared to homologous AZ + AZ or Pfizer + Pfizer strategies.

RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.

Superimunidade contra COVID: um dos maiores desafios da pandemia – “Pessoas que se recuperaram da COVID-19 apresentaram resposta imunológica mais forte após serem vacinadas do que pessoas não previamente infectadas. Cientistas tentam descobrir o motivo.”

27 Out, 2021 | 12:37h

COVID super-immunity: one of the pandemic’s great puzzles – Nature

O que a teoria dos jogos pode ensinar sobre o controle de pandemias.

27 Out, 2021 | 12:36h

What game theory can teach us about controlling pandemics – The BMJ Opinion

 

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Revisão sistemática | Antibióticos para o tratamento de COVID-19 – “Temos certeza de que o risco de morte em pacientes internados com COVID-19 não é reduzido pelo tratamento com azitromicina depois de 28 dias.”

26 Out, 2021 | 11:38h

Antibiotics for the treatment of COVID‐19 – Cochrane Library

 

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[Comunicado de imprensa – ainda não publicado] Moderna afirma que sua vacina contra COVID produz forte resposta imunológica em crianças de 6 a 11 anos.

26 Out, 2021 | 11:36h

Comunicado de imprensa: Moderna Announces Positive Top Line Data from Phase 2/3 Study of COVID-19 Vaccine in Children 6 to 11 Years of Age

Comentário: Moderna says new data supports its COVID vaccine for kids 6 to 11 – NPR

Infecção por Covid-19 traz um risco muito maior de desenvolvimento de complicações neurológicas do que as vacinas contra Covid-19.

26 Out, 2021 | 11:34h

Comunicado de imprensa: Infection with Covid-19 carries a much higher risk of developing neurological complications than a vaccine, says new study – University of Nottingham

Estudo original: Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection – Nature Medicine

Comentários:

Covid: Vaccine study links virus to rare neurological illness – BBC

Expert reaction to study looking at rare neurological complications after SARS-CoV-2 infection and COVID-19 vaccination – Science Media Centre

 

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Série de casos | Efeitos tóxicos do uso da ivermectina como prevenção e tratamento da Covid-19.

26 Out, 2021 | 11:32h

Toxic Effects from Ivermectin Use Associated with Prevention and Treatment of Covid-19 – New England Journal of Medicine

COVID: qual deve ser o nível de preocupação quanto à nova linhagem AY.4.2 do coronavírus?

26 Out, 2021 | 11:31h

COVID: how worried should we be about the new AY.4.2 lineage of the coronavirus? – The Conversation

Estudo de coorte | Superinfecção por pneumonia bacteriana em pacientes em ventilação mecânica devido a COVID-19 – “Superinfecção bacteriana dentro de 48 horas de intubação foi detectada em 21% dos pacientes.”

26 Out, 2021 | 11:30h

Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia – American Journal of Respiratory and Critical Care Medicine

Comentário: Potential Overuse of Antibiotics Found in Patients with Severe COVID-19 Pneumonia – American Thoracic Society

 

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O que significa estar totalmente vacinado.

26 Out, 2021 | 11:28h

What It Means To Be Fully Vaccinated – Think Global Health

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