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Acesso livre

Infectologia

Comunicado de imprensa – ainda não publicado] Estudo randomizado | Novo antiviral oral da Pfizer, candidato a tratamento da Covid-19, reduziu o risco de internação ou morte em 89% em análise interina da fase 2/3 do estudo EPIC-HR.

8 Nov, 2021 | 12:47h

Pfizer’s novel Covid-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR Study

Comentários:

Expert reaction to press release from Pfizer giving interim analysis of their Phase 2/3 EPIC-HR study of PAXLOVID™ in non-hospitalized high-risk adults with COVID-19 – Science Media Centre

Pfizer’s Good News Is the World’s Good News – Science

Experimental Pfizer pill prevents Covid hospitalizations and deaths – STAT

Pfizer Says New Anti-Viral Drug Combination Cuts Risks Of Serious COVID-19 By 89% – Health Policy Watch

Pfizer reports good results against severe COVID-19 for its antiviral pill – CIDRAP

Covid: Pfizer says antiviral pill 89% effective in high-risk cases – BBC

Pfizer says COVID-19 pill cut hospital, death risk by 90% – Associated Press

Pfizer’s COVID-19 pill treatment reduces risk of being hospitalized or dying by 89%, company says – ABC News

 

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[Ainda não publicado] Farmacêutica Sinovac afirma que sua vacina contra Covid-19 é segura para crianças e mesmo bebês a partir dos 6 meses de vida.

8 Nov, 2021 | 12:45h

Chinese drug firm Sinovac says Covid-19 vaccine safe for children, babies as young as six months old; submits data to Hong Kong government – South China Morning Post

Conteúdos relacionados:

Randomized phase 1/2 trial: Safety and immunogenicity of an inactivated COVID-19 vaccine, BBIBP-CorV, in children and adolescents aged 3–17 years.

Phase 1/2 RCT: CoronaVac is well tolerated and safe and induces strong humoral responses in children and adolescents aged 3–17 years.

Ponto de vista | Vacinas contra COVID-19 na pediatria: o que pais, médicos e formadores de políticas públicas precisam saber.

8 Nov, 2021 | 12:43h

Pediatric COVID-19 Vaccines: What Parents, Practitioners, and Policy Makers Need to Know – JAMA

Miocardite após vacina de mRNA contra COVID-19: uma série de casos e a determinação das taxas de incidência.

8 Nov, 2021 | 12:41h

Myocarditis Following COVID-19 mRNA Vaccine: A Case Series and Incidence Rate Determination – Clinical Infectious Diseases

Conteúdos relacionados:

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

Vacinação contra COVID-19 em gestantes, crianças, pacientes imunocomprometidos, pessoas com histórico de alergia ou infecção prévia por SARS-CoV-2: visão geral das recomendações atuais e evidências pré e pós-marketing da eficácia e da segurança das vacinas.

8 Nov, 2021 | 12:40h

COVID-19 Vaccination in Pregnancy, Paediatrics, Immunocompromised Patients, and Persons with History of Allergy or Prior SARS-CoV-2 Infection: Overview of Current Recommendations and Pre- and Post-Marketing Evidence for Vaccine Efficacy and Safety – Drug Safety

Ponto de vista | Crianças e COVID-19 nas escolas.

8 Nov, 2021 | 12:38h

Children and COVID-19 in schools – Science

Conteúdos relacionados:

Instead of quarantine for Covid-exposed students, some schools are trying test-to-stay.

Cluster RCT: Daily contact testing of school-based contacts was non-inferior to self-isolation for control of COVID-19 transmission.

Kids are losing school days to quarantines. Here’s a way to keep them in classrooms – “Test-to-stay could dramatically reduce close contact quarantines”.

Opinion | Data from routine Covid testing can help schools stay open this year.

CDC Report: Schools without mask requirements were more likely to have Covid-19 outbreaks.

Perspective | Schools have begun mass testing for COVID-19. But hurdles and uncertainties remain.

COVID and schools: the evidence for reopening safely.

COVID studies note online learning stress, fewer cases in schools with protocols

Alemanha oferece doses de reforço de vacina contra Covid-19 a todos em meio a um aumento de casos “muito preocupante”.

8 Nov, 2021 | 12:37h

Germany offers booster shots to everyone amid ‘very worrying’ surge in cases – CNN

Estudo compara a queda da efetividade das vacinas da Moderna, da Pfizer e da Janssen, além das consequências para a mortalidade.

5 Nov, 2021 | 17:21h

Estudo original: SARS-CoV-2 vaccine protection and deaths among US veterans during 2021 – Science

Comunicado de imprensa: Breakthrough Infection Study Compares Decline in Vaccine Effectiveness and Consequences for Mortality – Public Health Institute

 

Comentário no Twitter

 

Efeitos da pandemia de Covid-19 na expectativa de vida e na mortalidade prematura em 2020 – Esta análise mostrou que houve mais de 28 milhões de anos a mais de vida perdidos em 2020 em 31 países.

5 Nov, 2021 | 17:20h

Effects of covid-19 pandemic on life expectancy and premature mortality in 2020: time series analysis in 37 countries – The BMJ

Conteúdos relacionados:

Global Covid-19 deaths surpass five million.

Under-reporting of deaths limits our understanding of true burden of covid-19.

Study shows COVID-19 has caused the biggest decrease in life expectancy since World War II.

Just how do deaths due to COVID-19 stack up?

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.

Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.

Report: Three new estimates of India’s all-cause excess mortality during the COVID-19 Pandemic – pandemic death toll estimated to be between 3.4 million and 4.9 million excess deaths.

COVID-19 has caused 6.9 million deaths globally, more than double what official reports show

 

Comentário do autor no Twitter (fio – clique para saber mais)

 

Revisão | Transmissão do SARS-CoV-2 pelo ar em ambientes fechados é uma ameaça que pode ser combatida com ciência.

5 Nov, 2021 | 17:17h

SARS-CoV-2 indoor air transmission is a threat that can be addressed with science – Proceedings of the National Academies of Sciences

Conteúdos relacionados:

Ten scientific reasons in support of airborne transmission of SARS-CoV-2

Editorial: Covid-19 has redefined airborne transmission

Covid-19: What do we know about airborne transmission of SARS-CoV-2?

Real-world data show that filters clean COVID-causing virus from air.

Perspective | The plan to stop every respiratory virus at once – “The benefits of ventilation reach far beyond the coronavirus. What if we stop taking colds and flus for granted, too?”

Recommendations for ventilation of indoor spaces to reduce COVID-19 transmission.

We studied how to reduce airborne COVID spread in hospitals. Here’s what we learnt.

Report: Improved ventilation essential to safe use of buildings and public spaces, say leading engineers.

WHO: Roadmap to improve and ensure good indoor ventilation in the context of COVID-19

CDC releases new ventilation guidelines for indoor environments to reduce Covid-19 risk

Guidance: Using Ventilation and filtration to reduce aerosol transmission of COVID-19 in long-term care homes

It’s not just SARS-CoV-2: Most respiratory viruses spread by aerosols.

 

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