Infectologia Pediátrica

NEW—Cervical cancer rates 87% lower in women offered vaccination against human papillomavirus (#HPV) between ages 12-13 than in previous generations, English study confirms.

First direct evidence of cervical cancer prevention using bivalent vaccine: https://t.co/HdQbGIKxZp pic.twitter.com/PMFermHGOv

— The Lancet (@TheLancet) November 3, 2021

Conselho do CDC endossa a vacina da Pfizer contra Covid-19 para crianças de 5 a 11 anos.

3 Nov, 2021 | 11:18h

Slides da apresentação do ACIP: November 2-3, 2021 Meeting – Centers for Disease Control and Prevention

Comentários:

CDC advisors give go-ahead to COVID-19 vaccines for young kids – CIDRAP

CDC advisers endorse Pfizer’s Covid-19 vaccine for kids 5-11 – STAT

American Academy of Pediatrics Applauds CDC Advisory Committee’s Approval of Safe, Effective COVID-19 Vaccine for Children Ages 5-11

Estudo randomizado | Entre crianças com pneumonia adquirida na comunidade que receberam alta hospitalar ou do departamento de emergência dentro de 48 horas, uma dose menor de amoxicilina oral foi não inferior a uma dose maior, e o tratamento por 3 dias foi não inferior ao curso de 7 dias.

3 Nov, 2021 | 11:05h

Effect of Amoxicillin Dose and Treatment Duration on the Need for Antibiotic Re-treatment in Children With Community-Acquired Pneumonia: The CAP-IT Randomized Clinical Trial – JAMA (gratuito por tempo limitado)

Conteúdos relacionados:

ACP Guidance: Appropriate Use of Short-Course Antibiotics in Common Infections

RCT: 7 days of antibiotic therapy as good as 14 days for afebrile men with urinary tract infection.

RCT: A Seven-days course of antibiotics for the treatment of bloodstream infections by Enterobacterales was noninferior to a 14-days course.

RCT: Among patients with prosthetic joint infection, antibiotic therapy for 6 weeks was NOT shown to be noninferior to antibiotic therapy for 12 weeks and resulted in a higher percentage of patients with unfavorable outcomes.

Randomized Trial: Seven vs. Fourteen Days of Antibiotic Therapy for Uncomplicated Gram-negative Bacteremia

Comentário no Twitter

🔥Just published🔥
CAP-IT RCT
Children w CAP discharged from ED or hospital (w/in48 hrs)
lower-dose outpatient oral amoxicillin was noninferior to higher dose& 3d was noninferior to 7 d, w regard to need for Abx re-treatment @BradSpellberg table update 🤔 https://t.co/VkxBmJaEeW pic.twitter.com/fKzpGp1XM7

— Antibiotic Stewa®️x🆔 Bassam Ghanem (@ABsteward) November 2, 2021

Mortes associadas a COVID-19 e síndrome inflamatória multissistêmica em crianças (multisystem inflammatory syndrome – MIS-C) entre crianças e adolescentes nos Estados Unidos.

2 Nov, 2021 | 12:31h

Deaths in Children and Adolescents Associated With COVID-19 and MIS-C in the United States – Pediatrics

Conteúdos relacionados:

Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience – “Despite negligible fatality, complications including hospitalization, hypoxemia, and pneumonia were more frequent in children and adolescents with COVID-19 than with influenza”.

Deaths from COVID ‘incredibly rare’ among children.

[Preprint] Study confirms children’s extremely low risk of death from Covid-19 – “99·995% of children and young people with a positive SARS-CoV-2 test survived”.

Dois estudos observacionais levantam dúvidas sobre os efeitos do fechamento de escolas na redução da transmissão da Covid-19.

28 Out, 2021 | 16:15h

Estudo 1: No causal effect of school closures in Japan on the spread of COVID-19 in spring 2020 – Nature Medicine

Estudo 2: The impact of school opening model on SARS-CoV-2 community incidence and mortality – Nature Medicine

Comentários no Twitter

Results from a study in the US published in @NatureMedicine indicate that schools can reopen for in-person learning without substantially increasing community case rates of SARS-CoV-2. However, the impacts are variable and more study is needed. https://t.co/NFt1vNNb76 pic.twitter.com/fNgsJn6WLg

— Nature Portfolio (@NaturePortfolio) October 27, 2021

(fio – clique para saber mais)

2 new @NatureMedicine papers
First from half of US public school data
"Schools can open for in-person learning during the pandemic with minimal contribution to sustained community incidence of infections, provided other public safety measures are adopted."https://t.co/gn8MzrYVxE pic.twitter.com/qGfQLMzDEW

— Eric Topol (@EricTopol) October 27, 2021

O que as vacinas contra COVID em crianças mais novas podem significar para a pandemia.

28 Out, 2021 | 16:14h

What COVID vaccines for young kids could mean for the pandemic – Nature

Conteúdo relacionado: FDA advisory panel recommends Pfizer Covid-19 vaccine be authorized for children ages 5 to 11.

A procalcitonina tem utilidade clínica no tratamento da pneumonia pediátrica adquirida na comunidade? Um debate de prós e contras.

28 Out, 2021 | 16:02h

Does procalcitonin have clinical utility in the management of paediatric community-acquired pneumonia? A PRO/CON debate – JAC-Antimicrobial Resistance

PRO: Procalcitonin has clinical utility in children with community-acquired pneumonia

CON: Procalcitonin does not have clinical utility in children with community-acquired pneumonia

Estudo de coorte retrospectiva | Corticoterapia está relacionada a menor necessidade de drenagem cirúrgica em pacientes pediátricos com abscessos retro e parafaríngeos.

28 Out, 2021 | 15:58h

Corticosteroids in the Treatment of Pediatric Retropharyngeal and Parapharyngeal Abscesses – Pediatrics

Ponto de vista | Crianças e COVID-19 nas escolas.

Dez coisas a saber sobre a síndrome inflamatória multissistêmica em crianças (multisystem inflammatory syndrome in children – MIS-C).

Programa nacional de vacinação contra HPV na Inglaterra foi associado com uma redução estimada de 87% nas taxas de câncer do colo do útero naquelas que receberam a vacina entre 12-13 anos de idade.