Hematologia

Estudo randomizado | Em pacientes com fibrilação atrial ou valvas cardíacas mecânicas, tratados com warfarina e submetidos à cirurgia, o tratamento pós-operatório com “ponte” (bridging treatment) de heparina de baixo peso molecular não evitou tromboembolismo maior.

11 Jun, 2021 | 10:33h

Postoperative low molecular weight heparin bridging treatment for patients at high risk of arterial thromboembolism (PERIOP2): double blind randomised controlled trial – The BMJ

 

Comentário no Twitter

P-E-R-S-E-V-E-R-A-N-C-E = 15 yrs from start to BMJ publication. Bottom line: in pts with atrial fibrillation or mechanical heart valves who had warfarin interrupted for a procedure, we found no benefit of
postop LMWH bridging to prevent major
thromboembolism @canvector @CIHR_ICRH https://t.co/9z0XTQgsbA

— Susan R Kahn (@SusanRKahn1) June 10, 2021

 

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M-A | Segurança da toracocentese e do tubo de toracostomia em pacientes com coagulopatia não corrigida.

11 Jun, 2021 | 10:31h

Safety of Thoracentesis and Tube Thoracostomy in Patients With Uncorrected Coagulopathy: A Systematic Review and Meta-analysis – CHEST

Comentário: Is Thoracentesis Safe in Coagulopathic Patients? – JournalFeed

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Série de casos | Imunoglobulina adjuvante para trombocitopenia trombótica induzida por vacina.

10 Jun, 2021 | 09:07h

Adjunct Immune Globulin for Vaccine-Induced Thrombotic Thrombocytopenia – New England Journal of Medicine

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Revisão | Conduta em pacientes com tromboembolismo venoso após o período inicial de tratamento.

8 Jun, 2021 | 10:16h

Management of Patients With Venous Thromboembolism After the Initial Treatment Period – The Journal of the American Board of Family Medicine

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Estudo randomizado: Em pacientes internados com Covid-19 e D-dímero elevado, a estratégia de anticoagulação em dose plena baseada em rivaroxabam (dose plena de heparinas em pacientes instáveis) + rivaroxabam até o dia 30 não foi melhor do que a anticoagulação profilática e aumentou o risco de sangramento.

7 Jun, 2021 | 10:33h

Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial – The Lancet

Relacionado: #ACC21 – [Not published yet] RCT: Among hospitalized patients with Covid-19 and elevated D-Dimer, therapeutic anticoagulation with Rivaroxaban 20 mg was not associated with improved outcomes and resulted in increased major bleeding.

 

Comentário no Twitter

Thanks @CMichaelGibson. Another important contribution from the Brazilian Coalition team and investigators in Brazil. Our 6th trial completed in 12 months. Go coalition!!!! https://t.co/TDUr1RukuW

— Renato D Lopes (@RenatoDLopes1) June 4, 2021

 

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Relato de caso: Tratamento bem-sucedido da trombocitopenia imune protrombótica induzida por vacina (VIPIT – vaccine-induced prothrombotic immune thrombocytopenia).

7 Jun, 2021 | 10:28h

Successful treatment of vaccine-induced prothrombotic immune thrombocytopenia (VIPIT) – Journal of Thrombosis and Haemostasis

Comentário: COVID-19 vaccination: Thrombosis can be prevented by prompt treatment, researchers report – Medical University of Vienna

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Atualização do diagnóstico e do tratamento da síndrome POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes – polineuropatia, organomegalia, endocrinopatia, gamopatia monoclonal e alterações cutâneas).

7 Jun, 2021 | 10:13h

Update on the Diagnosis and Treatment of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome: A Review – JAMA Oncology (gratuito por tempo limitado)

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Diretriz | Profilaxia primária de infecções bacterianas e pneumonia por Pneumocystis jirovecii em pacientes com malignidades hematológicas e tumores sólidos.

31 Mai, 2021 | 12:06h

Primary prophylaxis of bacterial infections and Pneumocystis jirovecii pneumonia in patients with hematologic malignancies and solid tumors: 2020 updated guidelines of the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology (AGIHO/DGHO) – Annals of Hematology

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Transfusão na anemia grave em crianças africanas: um algoritmo de consenso.

25 Mai, 2021 | 15:42h

Transfusion management of severe anaemia in African children: a consensus algorithm – British Journal of Haematology

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[Preprint] Estudo randomizado para mudança de prática: Dose terapêutica de anticoagulação com heparina (HBPM ou heparina não fracionada) melhora o desfecho em pacientes não críticos com Covid-19 – a superioridade da heparina em dose plena foi observada tanto em grupos com D-dímero alto quanto baixo.

18 Mai, 2021 | 11:02h

Therapeutic Anticoagulation in Non-Critically Ill Patients with Covid-19 – medRxiv

Relacionado: [Preprint] RCT: Full-dose/therapeutic anticoagulation provides no benefit in critically ill patients with Covid-19

 

Comentário no Twitter

Final results of the mpRCT now on preprint server. In non-critically ill patients with COVID-19 (n=2219), therapeutic-dose anticoagulation with heparins increases survival to hospital discharge with reduced use of organ support. https://t.co/TkhGs5qow5

— Ryan Zarychanski (@RZarychanski) May 17, 2021

 

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