Geriatria

Revisão | Menos é mais: deprescrição de medicamentos em idosos com doença renal.

14 Abr, 2022 | 17:41h

Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360

Conteúdos relacionados:

Process evaluation of implementation strategies to reduce potentially inappropriate medication prescribing in older population: A scoping review.

AGA clinical practice update on de-prescribing of proton pump inhibitors.

Development of a metric to detect and decrease low-value prescribing in older adults.

Cluster Randomized Clinical Trial: An electronic decision support system for deprescribing in hospitalized older adults was safe and led to improvements in deprescribing but did not reduce adverse drug events.

Systematic Review: Quantifying anticholinergic burden and sedative load in older adults with polypharmacy.

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines.

Systematic review: Prescribing practices, patterns, and potential harms in patients receiving palliative care – “many patients receiving palliative care receive multiple medications closer to the time of death”.

A narrative review of evidence to guide deprescribing among older adults.

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens.

Polypharmacy Management in Older Patients – Mayo Clinic Proceedings

Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy – Deutsches Ärzteblatt internationa

Eliminating Medication Overload: A National Action Plan

Deprescribing in Older Adults With Cardiovascular Disease – Journal of the American College of Cardiology

Position Statement: Reducing Inappropriate Medication Use & Polypharmacy (vários artigos e comentários sobre o tema)

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Novas descobertas sobre a etiologia genética da doença de Alzheimer e demências relacionadas.

14 Abr, 2022 | 17:36h

New insights into the genetic etiology of Alzheimer’s disease and related dementias – Nature Genetics

Comunicado de imprensa: Landmark study reveals 42 new genes associated with increased risk of Alzheimer’s disease – UK Dementia Research Institute

Comentários:

42 previously unknown genes discovered for Alzheimer’s disease – CNN

Alzheimer’s disease research takes ‘major leap forward’ – BBC

Expert reaction to study of genes associated with increased risk of Alzheimer’s – Science Media Centre

 

Comentário no Twitter

A meta-analysis in @NatureGenet of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia. https://t.co/EAtdlRozld pic.twitter.com/5rtWWt4HyS

— Nature Portfolio (@NaturePortfolio) April 11, 2022

 

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Diretriz clínica do Reino Unido para prevenção e tratamento de osteoporose.

12 Abr, 2022 | 12:33h

UK clinical guideline for the prevention and treatment of osteoporosis – Archives of Osteoporosis

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Estudo ASCEND | Efeitos da aspirina sobre a demência e a função cognitiva em pacientes diabéticos.

12 Abr, 2022 | 12:09h

Effects of aspirin on dementia and cognitive function in diabetic patients: the ASCEND trial – European Heart Journal

Estudo original: Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes

 

Comentário no Twitter (imagens sob licença de https://creativecommons.org/licenses/by/4.0/)

Does aspirin have an effect on dementia and cognitive function? Discover it in the EHJ!https://t.co/u5X1fxrULk#aspirin #dementia #CVD #ASCEND #trial #diabetes #cardiotwitter @escardio @ESC_Journals pic.twitter.com/TyrnUnf0MN

— EHJ Editor-in-Chief (@ehj_ed) April 8, 2022

 

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Estudo de coorte | Uso de inibidores da fosfodiesterase 2 está associado a risco aumentado de eventos adversos oculares.

11 Abr, 2022 | 13:05h

Risk of Ocular Adverse Events Associated With Use of Phosphodiesterase 5 Inhibitors in Men in the US – JAMA Ophthalmology (gratuito por tempo limitado)

Comunicado de imprensa: U.S. insurance claims show strong link between ED medications and vision problems – University of British Columbia

Comentários:

Phase 4 Studies on Phosphodiesterase 5 Inhibitors – JAMA Ophthalmology (gratuito por tempo limitado)

Expert reaction to study looking at risk of vision impairment and loss, and use of phosphodiesterase type 5 inhibitors – Science Media Centre

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Estudo randomizado | Efetividade clínica de injeção intra-articular guiada por ultrassonografia com corticosteroide e anestésico local para a osteoartrite de quadril.

8 Abr, 2022 | 21:39h

Clinical effectiveness of one ultrasound guided intra-articular corticosteroid and local anaesthetic injection in addition to advice and education for hip osteoarthritis (HIT trial): single blind, parallel group, three arm, randomised controlled trial – The BMJ

Comunicado de imprensa: Steroid injections may provide longer lasting benefits for hip pain than current best care – BMJ

 

Comentário no Twitter

Adding an ultrasound guided corticosteroid and local anaesthetic injection to advice and education offers rapid and sustained improvements in pain and function, finds new research https://t.co/fQHzvKv2wL

— The BMJ (@bmj_latest) April 7, 2022

 

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Estudo randomizado | Efeitos da injeção de glicocorticoide intramuscular vs. intra-articular sobre a dor em adultos com osteoartrite de joelho.

8 Abr, 2022 | 21:37h

Effect of Intramuscular vs Intra-articular Glucocorticoid Injection on Pain Among Adults With Knee Osteoarthritis: The KIS Randomized Clinical Trial – JAMA Network Open

 

Comentário no Twitter

This RCT found IM steroid injections were inferior to intrarticular injections for reducing pain in patients with knee osteoarthritis at 4 weeks but were noninferior at 8 and 24 weeks after injection. https://t.co/opq1C2BP8c pic.twitter.com/ucx4lvRDJQ

— JAMA Network Open (@JAMANetworkOpen) April 5, 2022

 

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Aprendizado profundo (deep learning) baseado em fotografia da retina prediz idade biológica e estratifica os riscos de morbidade e mortalidade.

8 Abr, 2022 | 21:31h

Retinal photograph-based deep learning predicts biological age, and stratifies morbidity and mortality risk – Age and Ageing

Conteúdo relacionado: Study shows that the retinal age gap might be a potential biomarker of aging linked to increased mortality risk.

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Revisão sistemática | Manejo da dor baseado em algoritmo para pessoas com demência em casas de repouso.

8 Abr, 2022 | 21:18h

Algorithm‐based pain management for people with dementia in nursing homes – Cochrane Library

Resumo: Step-by-step (algorithm-based) pain management for people with dementia living in nursing homes – Cochrane Library

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Revisão | Fibrilação atrial em idosos com câncer.

8 Abr, 2022 | 16:51h

Atrial fibrillation in older adults with cancer – Journal of Geriatric Cardiology

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