Farmácia/Notícias da Indústria

O que é “breakthrough infection”? 6 questões e respostas sobre infecções por SARS-CoV-2 adquiridas após vacinação.

2 Ago, 2021 | 17:38h

What is a breakthrough infection? 6 questions answered about catching COVID-19 after vaccination – The Conversation

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Dados mostram que a eficácia da vacina da Pfizer/BioNTech contra Covid cai para 84% depois de 6 meses.

2 Ago, 2021 | 17:35h

Efficacy of Pfizer/BioNTech Covid vaccine slips to 84% after six months, data show – STAT

Estudo original (preprint): Six Month Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine – medRxiv

 

Comentário no Twitter (fio – clique para saber mais)

6-month followup for major BNT-Pfizer vax trial. While still blinded, overall vaccine efficacy was:

– against symptomatic Covid-19: 91.1% (89-93)
– against severe Covid-19: 96.7% VE (80-99.9)

…1/nhttps://t.co/B6JVxJeS2C (preprint) pic.twitter.com/KlwwjoqrfZ

— Hilda Bastian, PhD (@hildabast) July 28, 2021

 

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Consenso de especialistas da ACC para a redução do risco cardiovascular em pacientes com hipertrigliceridemia persistente.

2 Ago, 2021 | 17:33h

2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia: A Report of the American College of Cardiology Solution Set Oversight Committee – Journal of the American College of Cardiology

Pontos principais: ACC Consensus on ASCVD Risk Reduction in Hypertriglyceridemia – American College of Cardiology

 

Comentário no Twitter

The ACC Expert Consensus Decision Pathway highlights 9️⃣ key points to remember on the management of atherosclerotic #CVD risk reduction in patients with persistent hypertriglyceridemia. Learn more here: https://t.co/zTx4gsIQS2 #ASCVD #cvCAD #Diabetes @virani_md @PamelaBMorris pic.twitter.com/Zjo4wmeZVj

— American College of Cardiology (@ACCinTouch) July 28, 2021

 

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Posicionamento Científico ESC | Efeitos metabólicos, cardíacos e renais dos inibidores de SGLT2.

2 Ago, 2021 | 17:29h

Cardiac, renal, and metabolic effects of sodium–glucose co-transporter 2 inhibitors: a position paper from the European Society of Cardiology ad-hoc task force on sodium–glucose co-transporter 2 inhibitors – European Journal of Heart Failure

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Análise das evidências | Piperacilina-tazobactam é segura em pacientes alérgicos à penicilina?

2 Ago, 2021 | 17:20h

Is piperacillin-tazobactam safe in patients with penicillin allergy? – PulmCrit

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Estudo de coorte | Evidência de uma “cascata de prescrição” potencialmente danosa e inadequada de gabapentinoide seguida de diurético em idosos com dor lombar.

2 Ago, 2021 | 17:19h

Evidence of a gabapentinoid and diuretic prescribing cascade among older adults with lower back pain – Journal of the American Geriatrics Society (link para o resumo – $ para o texto completo)

Conteúdo relacionado:

Are you the victim of a prescribing cascade?

Study: Evaluation of a Common Prescribing Cascade of Calcium Channel Blockers and Diuretics in Older Adults with Hypertension

Prescribing Cascade in a Cardiology Practice

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Casos muito raros da síndrome de trombose com trombocitopenia (STT) após vacina AstraZeneca – A estimativa de STT após a primeira dose foi de 8,1 por milhão de vacinas; depois da segunda dose, a estimativa foi de 2,3 por milhão de vacinas.

2 Ago, 2021 | 17:05h

Very rare thrombosis with thrombocytopenia after second AZD1222 dose: a global safety database analysis – The Lancet

Conteúdos relacionados:

WHO Guidance for clinical case management of thrombosis with thrombocytopenia syndrome (TTS) following vaccination to prevent coronavirus disease (COVID-19).

AHA/ASA Guidance: Diagnosis and Management of Cerebral Venous Sinus Thrombosis with Vaccine-Induced Thrombotic Thrombocytopenia – “No heparin products in any dose should be given.”

ISTH Interim Guidance for the Diagnosis and Treatment on Vaccine Induced Immune Thrombotic Thrombocytopenia

Case series: therapeutic plasma exchange in 3 patients with vaccine-induced immune thrombotic thrombocytopenia.

Vaccine-induced immune thrombotic thrombocytopenia (VITT) – a novel clinico-pathological entity with heterogeneous clinical presentations.

Case report: Thrombosis with Thrombocytopenia After the Messenger RNA–1273 Vaccine.

Laboratory testing for suspected COVID-19 vaccine–induced (immune) thrombotic thrombocytopenia.

Concerned about the latest AstraZeneca news? These 3 graphics help you make sense of the risk – “Two people in Australia have died from thrombosis with thrombocytopenia after 3.8 million doses of the AstraZeneca vaccine delivered”.

Case series: Adjunct immune globulin for vaccine-induced thrombotic thrombocytopenia.

Case report: Successful treatment of vaccine-induced prothrombotic immune thrombocytopenia (VIPIT).

[Preprint] Meta-analysis of risk of vaccine-induced immune thrombotic thrombocytopenia following ChAdOx1-S recombinant vaccine – Overall risk is 1 in 139,000; for age 65 and over, about 1 in 1,000,000; for age under 55, between 1 in 20,000 to 60,000.

Cohort study: Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdOx1-S. 11 excess venous thromboembolic events per 100 000 vaccinations; 2.5 excess cerebral venous thrombosis per 100 000 vaccinations.

Case series of 12 patients with cerebral venous sinus thrombosis with thrombocytopenia after Ad26.COV2.S vaccination – all women younger than 60 years, with symptoms from 6 to 15 days after vaccination

Vaccine-induced Immune Thrombotic Thrombocytopenia: Frequently Asked Questions

Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination

Editorial: SARS-CoV-2 Vaccine–Induced Immune Thrombotic Thrombocytopenia – “The very low prevalence of this complication of vaccination, however severe, relative to the benefits of preventing Covid-19 must be emphasized”

Case Report: Thrombotic Thrombocytopenia after Johnson & Johnson Vaccine

Papers Confirm Rare Thrombocytopenia Link to AstraZeneca Vaccine

Guidance on syndrome of Thrombosis and Thrombocytopenia occurring after coronavirus Vaccination

 

Comentário no Twitter

Vaccine-induced thrombotic thrombocytopenia (VITT or TTS) events are extremely rare w/ the adenovirus vector vaccines. A new report by @AstraZeneca @TheLancet addresses after 2nd AZ dose w/ details in 13 peoplehttps://t.co/Rf3euuQai5
1st dose : 8.1/ million
2nd dose: 2.3/million pic.twitter.com/GoOqWIRZfw

— Eric Topol (@EricTopol) July 27, 2021

 

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Estudo randomizado | Antibioticoterapia por 7 dias é tão boa quanto por 14 dias para homens com infecção de trato urinário que estejam sem febre.

2 Ago, 2021 | 16:51h

Effect of 7 vs 14 Days of Antibiotic Therapy on Resolution of Symptoms Among Afebrile Men With Urinary Tract Infection: A Randomized Clinical Trial – JAMA (gratuito por tempo limitado)

Editorial: Shorter Courses of Antibiotics for Urinary Tract Infection in Men (gratuito por tempo limitado)

Comentário: Study Supports Shorter Antibiotic Course for Afebrile Men With UTI – MPR

 

Comentário no Twitter

Practice changing study, we always consider UTI in men as a complicated disease and we usually treat for longer time sometimes even more than 14 days, this study found that you can treat for shorter time ~7 days #IDTwitter #medtwitter #TwitteRx https://t.co/LSWYTAG15y

— Antibiotic Steward 🆔🇵🇸 Bassam Ghanem (@ABsteward) July 27, 2021

 

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Consenso ESC | Terapias antitrombóticas nas doenças arteriais aórticas e periféricas em 2021.

2 Ago, 2021 | 16:44h

Antithrombotic therapies in aortic and peripheral arterial diseases in 2021: a consensus document from the ESC working group on aorta and peripheral vascular diseases, the ESC working group on thrombosis, and the ESC working group on cardiovascular pharmacotherapy – European Heart Journal

Pontos principais a lembrar: ESC Consensus on Antithrombotic Therapies in Aortic and Peripheral Artery Diseases – American College of Cardiology

 

Comentário no Twitter

The new consensus document from the ESC working group on aorta and peripheral vascular diseases on best antithrombotic strategies!#aorta #antithrombotic #therapy #EHJ #cardiotwitter@escardio @ESC_Journals https://t.co/ga17wxKDGi pic.twitter.com/CSSgE5TFdX

— EHJ Editor-in-Chief (@ehj_ed) July 23, 2021

 

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Revisão | Terapia anabólica para osteoporose.

2 Ago, 2021 | 16:39h

Anabolic Therapy for Osteoporosis – JAMA (gratuito por tempo limitado)

Entrevista com a autora: Anabolic Therapy for Osteoporosis

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