Acesso livre
Acesso livre

Estudos Randomizados

Estudo randomizado | Eficácia analgésica da dexametasona intravenosa como um adjunto ao bloqueio paravertebral na cirurgia toracoscópica.

4 Out, 2022 | 12:27h

Analgesic Efficacy of Intravenous Dexamethasone as an Adjunct to Ultrasound-Guided Paravertebral Block with Bupivacaine in Video-Assisted Thoracoscopic Surgery – Journal of Pain Research

 

Estudo randomizado | Antibioticoprofilaxia vs. nenhuma profilaxia na cirurgia de câncer de mama.

4 Out, 2022 | 12:26h

Antibiotic prophylaxis in breast cancer surgery (PAUS trial): randomised clinical double-blind parallel-group multicentre superiority trial – British Journal of Surgery (link para o resumo – $ para o texto completo)

 

Estudo randomizado | Selumetinibe com iodo radioativo adjuvante em pacientes com câncer de tireoide diferenciado de alto risco.

4 Out, 2022 | 12:22h

Selumetinib Plus Adjuvant Radioactive Iodine in Patients With High-Risk Differentiated Thyroid Cancer: A Phase III, Randomized, Placebo-Controlled Trial (ASTRA) – Journal of Clinical Oncology

Comentário: Selumetinib Does Not Improve CR Rate in Differentiated Thyroid Cancer – Cancer Therapy Adviser

 

Comentário no Twitter

 

Estudo randomizado | Não há benefício do uso de hidrocortisona, vitamina C e tiamina em pacientes adultos com choque séptico.

3 Out, 2022 | 12:56h

Early administration of hydrocortisone, vitamin C, and thiamine in adult patients with septic shock: a randomized controlled clinical trial – Critical Care

Conteúdos relacionados:

Parenteral Vitamin C in Patients with Severe Infection: A Systematic Review – NEJM Evidence

Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit – New England Journal of Medicine

Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis – Intensive Care Medicine

Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial – JAMA

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial – JAMA

 

Estudo randomizado | Autocorte vs. kit com tela de polipropileno e coberta por titânio para tratamento transvaginal de prolapso grave de órgão pélvico.

3 Out, 2022 | 12:51h

Effectiveness of Self-cut vs Mesh-Kit Titanium-Coated Polypropylene Mesh for Transvaginal Treatment of Severe Pelvic Organ ProlapseA Multicenter Randomized Noninferiority Clinical Trial – JAMA Network Open

Comentário: Self-Cut Mesh Noninferior for Pelvic Organ Prolapse Procedure – HealthDay

 

Revisão sistemática | Estudos clínicos randomizados sobre intervenções de aprendizado de máquina (machine learning) na atenção à saúde.

3 Out, 2022 | 12:50h

Randomized Clinical Trials of Machine Learning Interventions in Health Care: A Systematic Review – JAMA Network Open

 

Estudo randomizado | Doxiciclina vs. placebo em pacientes com oftalmopatia leve associada a tireoide.

3 Out, 2022 | 12:47h

Doxycycline vs Placebo at 12 Weeks in Patients With Mild Thyroid-Associated Ophthalmopathy: A Randomized Clinical Trial – JAMA Ophthalmology (gratuito por tempo limitado)

Comentário convidado: Oral Doxycycline for Mild Thyroid Eye Disease – JAMA Opthalmology (gratuito por tempo limitado)

 

Estudo randomizado | Nivolumabe adjuvante com ipilimumabe vs. nivolumabe isolado em pacientes com melanoma estágio IIIB-D ou IV ressecado.

3 Out, 2022 | 12:45h

Adjuvant Therapy of Nivolumab Combined With Ipilimumab Versus Nivolumab Alone in Patients With Resected Stage IIIB-D or Stage IV Melanoma (CheckMate 915) – Journal of Clinical Oncology

 

Estudo randomizado | Em pacientes com queimaduras graves, a suplementação de glutamina não melhorou os desfechos.

13 Set, 2022 | 12:11h

A Randomized Trial of Enteral Glutamine for Treatment of Burn Injuries – New England Journal of Medicine (link para o resumo – $ para o texto completo)

 

Comentário no Twitter

 

Dois grandes estudos clínicos mostraram que suplementos de vitamina D não reduzem o risco de Covid-19.

13 Set, 2022 | 12:08h

Estudo 1: Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT) – The BMJ

Estudo 2: Prevention of covid-19 and other acute respiratory infections with cod liver oil supplementation, a low dose vitamin D supplement: quadruple blinded, randomised placebo controlled trial – The BMJ

Editorial: Can vitamin D protect against covid-19? – The BMJ

Comunicado de imprensa: No link between vitamin D supplements and reduced risk of covid-19 – BMJ Newsroom

 

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