Estudos Randomizados
Estudo randomizado | Sintilimabe com bevacizumabe biossimilar vs. sorafenibe no carcinoma hepatocelular irressecável.
22 Jul, 2021 | 12:59hSintilimab plus a bevacizumab biosimilar (IBI305) versus sorafenib in unresectable hepatocellular carcinoma (ORIENT-32): a randomised, open-label, phase 2–3 study – The Lancet Oncology (link para o resumo – $ para o texto completo)
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In a phase III trial involving 571 pts with unresectable HCC, the anti-PD-1 mAb sintilimab + the bevacizumab biosimilar IBI305 improved PFS (median 4.6 vs 2.8 months with sorafenib; HR 0.56, P <0.0001) & OS (median NR vs 10.4 months; HR 0.57, P <0.0001), https://t.co/UF43FGdMMy
— NatureRevClinOncol (@NatRevClinOncol) June 22, 2021
Estudo randomizado | Realimentação oral imediata em pacientes com pancreatite aguda leve e moderada.
22 Jul, 2021 | 12:50hImmediate Oral Refeeding in Patients With Mild and Moderate Acute Pancreatitis: A Multicenter, Randomized Controlled Trial (PADI trial) – Annals of Surgery (link para o resumo – $ para o texto completo)
Estudo randomizado | Não há benefício na injeção de plasma rico em plaquetas para pacientes com tendinopatia do calcâneo (tendão de Aquiles) debilitante.
19 Jul, 2021 | 09:48hEffect of Platelet-Rich Plasma Injection vs Sham Injection on Tendon Dysfunction in Patients With Chronic Midportion Achilles Tendinopathy: A Randomized Clinical Trial – JAMA (gratuito por tempo limitado)
Comentário: No benefit from PRP treatment for patients with debilitating Achilles tendon pain – University of Warwick
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A single injection of platelet-rich plasma compared with a sham injection did not significantly reduce #Achillestendon dysfunction https://t.co/K4YKHSbxZY
— JAMA (@JAMA_current) July 13, 2021
Estudos randomizado | Efeito da facilitação por neurofeedback na recuperação da marcha e do equilíbrio pós-AVC.
16 Jul, 2021 | 09:41hComentário: Neurofeedback Facilitation Improves Gait and Balance in Post-Stroke Patients – BrainPost
Estudo randomizado | Banlanivimabe com etesevimabe reduz a mortalidade e a hospitalização em pacientes ambulatoriais com início de Covid-19 (até 3 dias de um teste positivo) que estão sob risco de piora clínica (p.ex., idosos, obesos, diabéticos, imunocomprometidos, portadores de doença cardiovascular).
15 Jul, 2021 | 10:41hBamlanivimab plus Etesevimab in Mild or Moderate Covid-19 – New England Journal of Medicine
Estudo randomizado | Ranibizumabe intravítreo vs. aflibercepte vs. bevacizumabe para edema macular decorrente de oclusão da veia central da retina.
15 Jul, 2021 | 10:27hOutro estudo randomizado avaliou a eficácia e a qualidade de vida no tratamento somente com antibióticos da apendicite aguda não complicada.
13 Jul, 2021 | 11:16hA Randomized Clinical Trial Evaluating the Efficacy and Quality of Life of Antibiotic-only Treatment of Acute Uncomplicated Appendicitis: Results of the COMMA Trial – Annals of Surgery (link para o resumo – $ para o texto completo)
Relacionado: A Randomized trial comparing antibiotics with appendectomy for appendicitis E Antibiotics alone for uncomplicated appendicitis: Oral Moxifloxacin almost as good as intravenous Ertapenem + oral Levofloxacin E Observational study: 67.1% success rate with nonoperative management of children with uncomplicated appendicitis E Randomized Trial: Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs. Appendectomy for Uncomplicated Acute Appendicitis E Meta-Analysis: Antibiotic Treatment vs. Appendectomy for Uncomplicated Acute Appendicitis in Adults and Children E Nonoperative treatment for nonperforated appendicitis in children: a systematic review and meta-analysis – Pediatric Surgery International
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The debate continues!
Another RCT comparing antibiotics to surgery for uncomplicated appendicitis – COMMA trial from 🇮🇪
Recurrence within 1-year : 25% after AB
Superior quality of life at 3 and 12mo after surgery.https://t.co/Yv51qpxchb
— Ville Sallinen (@villesallinen) July 11, 2021
Estudo randomizado | Imobilização gessada tradicional não é superior à imobilizador removível em adultos com fratura de tornozelo.
12 Jul, 2021 | 11:15hComunicado de imprensa: Cast no better than brace for broken ankles – University of Warwick
Estudo randomizado | Ressonância magnética reduz à metade os casos de “overdiagnosis” no rastreamento do câncer de próstata.
9 Jul, 2021 | 15:51hMRI-Targeted or Standard Biopsy in Prostate Cancer Screening – New England Journal of Medicine (link para o resumo – $ para o texto completo)
Comunicado de imprensa: MRI can cut overdiagnoses in prostate-cancer screening by half – Karolinska Institutet
Artigos relacionados: RCT: MRI-targeted biopsy safely reduces the need for biopsy in more than one-third of men at risk for prostate cancer E Meta-Analysis: Negative Predictive Value of MRI in the Detection of Clinically Significant Prostate Cancer E Study: MRI-Targeted, Systematic, and Combined Biopsy for Prostate Cancer Diagnosis E Review: The Use of MRI and PET Imaging Studies for Prostate Cancer Management E Meta-Analysis: MRI plus Targeted Biopsy vs. Systematic Biopsy Alone for the Diagnosis of Prostate Cancer E Cochrane Review: MRI Pathway vs. Systematic Biopsy for Detecting Prostate Cancer E Meta-analysis: Clinical Utility of MRI in the Decision-making Process Before Radical Prostatectomy E Research: Biparametric MRI (simpler, faster) May Be Used to Exclude Aggressive Disease and Avoid Unnecessary Biopsies in Men with Clinical Suspicion of Prostate Cancer E Research: MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis E Multiparametric MRI in the Detection of Clinically Significant Prostate Cancer