Estudos Randomizados
Estudo randomizado | Combinação de anticorpos REGEN-COV reduz hospitalizações em pacientes ambulatoriais com Covid-19.
1 Out, 2021 | 20:28hEstudo randomizado | Manutenção vs. descontinuação de antidepressivos em pacientes que se sentem bem o suficiente para suspender a terapia antidepressiva.
1 Out, 2021 | 20:18hMaintenance or Discontinuation of Antidepressants in Primary Care – New England Journal of Medicine
Comentários:
Many can stop anti-depressants without relapse – BBC
Study highlights difficulty of stopping antidepressants – Associated Press
Estudo randomizado | Bloqueio neurolítico de nervo esplâncnico e alívio da dor, sobrevida e qualidade de vida no câncer pancreático irressecável.
1 Out, 2021 | 20:14h
Comentário no Twitter
Neurolytic Splanchnic Nerve Block and Pain Relief, Survival, and Quality of Life in Unresectable Pancreatic Cancer: A Randomized Controlled Trial https://t.co/xa9sPAdQu1 pic.twitter.com/gi74fdDSfl
— Anesthesiology journal (@_Anesthesiology) August 30, 2021
Estudo randomizado | Benefício de sobrevida global com tebentafuspe no melanoma uveal metastático.
1 Out, 2021 | 18:33h
Comentário no Twitter
Treatment with tebentafusp resulted in longer overall survival than the control therapy among previously untreated patients with metastatic uveal melanoma. https://t.co/HnSdWItKIp pic.twitter.com/qu4huRn3Mu
— NEJM (@NEJM) September 27, 2021
Estudo randomizado | Tansulosina pode evitar a retenção urinária pós-operatória depois de uma cirurgia de reconstrução pélvica feminina.
17 Set, 2021 | 12:51hTamsulosin vs placebo to prevent postoperative urinary retention following female pelvic reconstructive surgery: a multicenter randomized controlled trial – American Journal of Obstetrics & Gynecology (link para o resumo – $ para o texto completo)
Estudo randomizado | Efeito do canrelizumabe vs. placebo adicionado à quimioterapia na sobrevida e na sobrevida livre de progressão em pacientes com carcinoma esofágico de células escamosas avançado ou metastático.
17 Set, 2021 | 11:55hEffect of Camrelizumab vs Placebo Added to Chemotherapy on Survival and Progression-Free Survival in Patients With Advanced or Metastatic Esophageal Squamous Cell Carcinoma: The ESCORT-1st Randomized Clinical Trial – JAMA (gratuito por tempo limitado)
Editorial: Immunotherapy for Advanced Esophageal Squamous Cell Carcinoma—Renewed Enthusiasm and a Lingering Challenge – JAMA Oncology (gratuito por tempo limitado)
Comentário no Twitter
Among patients with advanced or metastatic esophageal squamous cell carcinoma, the addition of camrelizumab to chemotherapy, compared with placebo and chemotherapy, significantly improved overall survival and progression-free survival https://t.co/DAlhmtgvv1
— JAMA (@JAMA_current) September 14, 2021
Estudo randomizado | Plasma convalescente não melhora os desfechos e pode ser prejudicial a pacientes hospitalizados com COVID-19.
12 Set, 2021 | 21:56hComunicado de imprensa: Major study finds convalescent plasma doesn’t help seriously ill COVID-19 patients – McMaster University
Conteúdos relacionados:
M-A: Convalescent plasma is safe but does not improve outcomes in the treatment of COVID-19.
RECOVERY Trial: No benefit from convalescent plasma in patients admitted to hospital with COVID-19.
Comentário no Twitter
A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, according to a @NatureMedicine paper. https://t.co/7JFhEXLmbA pic.twitter.com/Q3e50Q0I7T
— Nature Portfolio (@NaturePortfolio) September 9, 2021
Estudo randomizado | Em pacientes submetidos a cirurgias de grande porte, ter como alvo uma anestesia mais leve reduziu o risco de delirium pós-operatório e comprometimento cognitivo em 1 ano.
12 Set, 2021 | 21:43hAnaesthetic depth and delirium after major surgery: a randomised clinical trial – British Journal of Anaesthesia (link para o resumo – $ para o texto completo)
[Preprint] Estudo randomizado | Reforço vacinal com vacina heteróloga vs. homóloga em pacientes imunossuprimidos sem soroconversão de anticorpo contra SARS-CoV-2 após vacinação primária com vacina de mRNA.
12 Set, 2021 | 20:55h
Comentário no Twitter (fio – clique para saber mais)
Results of 60-person randomized trial of 3rd shot of mRNA or AZ vax in people on rituximab who didn't seroconvert after BNT-Pfizer (most) or Moderna vax. Found dose 3 reduced those with no humoral or cellular response from 31% to 6% …1/2 https://t.co/HIjeDaFy7w Preprint #IC
— Hilda Bastian, PhD (@hildabast) September 8, 2021
Estudo randomizado | Um curso de 7 dias de antibióticos para o tratamento de infecções da corrente sanguínea por enterobactérias não foi inferior a um curso de 14 dias.
12 Set, 2021 | 20:14h
Comentário no Twitter
SHORTEN RCT 🔥🔥🔥@CMIJournal
Seven versus 14-days course of antibiotics for the treatment of bloodstream infections by Enterobacterales
7-day course of antibiotics as the preferential treatment for eBSI, as long as the source is properly controlled https://t.co/pyaOMl52us pic.twitter.com/wK1sgeMe36— Antibiotic Steward 🆔🇵🇸 Bassam Ghanem (@ABsteward) September 8, 2021