Estudos Randomizados
Estudo randomizado | Suplementação de vitamina D não melhora os desfechos em pessoas com psicose de início recente.
10 Jan, 2022 | 12:07hEstudo randomizado | Radioterapia pós-cirúrgica não aumentou a sobrevida livre de doença em pacientes com câncer de pulmão não pequenas células completamente ressecado com envolvimento N2 mediastinal comprovado.
10 Jan, 2022 | 11:51hPostoperative radiotherapy versus no postoperative radiotherapy in patients with completely resected non-small-cell lung cancer and proven mediastinal N2 involvement (Lung ART): an open-label, randomised, phase 3 trial – The Lancet Oncology (link para o resumo – $ para o texto completo)
Comentários:
Post-Operative Radiotherapy Not Tied to Better Disease-Free Survival in NSCLC – MedPage Today (gratuito por tempo limitado)
Estudos de fase 3 com tapinarofe em creme para psoríase em placas.
16 Dez, 2021 | 12:47hPhase 3 Trials of Tapinarof Cream for Plaque Psoriasis – New England Journal of Medicine
Comentário: Topical tapinarof reduces severity of plaque psoriasis – HealthDay
Comentário no Twitter
In two trials of treatment for psoriasis with the topical aryl hydrocarbon receptor–modulating agent tapinarof, clearance of lesions occurred in a larger proportion of patients who used tapinarof cream than of those who used placebo. https://t.co/I4zgVFELhz pic.twitter.com/qT6lbaJK0U
— NEJM (@NEJM) December 10, 2021
Estudo randomizado | Maribavir para infecções por citomegalovírus refratárias com ou sem resistência pós-transplante.
7 Dez, 2021 | 11:29hEstudo randomizado | Desfechos de longo prazo com nivolumabe associado a ipilimumabe ou nivolumabe isolado vs. ipilimumabe em pacientes com melanoma avançado.
6 Dez, 2021 | 15:51hEditorial: CheckMate-067: Raising the Bar for the Next Decade in Oncology – Journal of Clinical Oncology
Estudo original: #ESMO19 – Randomized Trial: Improved Overall Survival at 5 Years with Combined Immunotherapy for Advanced Melanoma
Ensaios clínicos randomizados na terapia intensiva: passado, presente e futuro.
3 Dez, 2021 | 11:00hRandomised clinical trials in critical care: past, present and future – Intensive Care Medicine
Comentário no Twitter
RCTs in critical care, history, major challenges & limitations, recent developments trying to solve some of these
📊conventional & novel RCTs
📊rationale for choosing methodological approach (advantages/potential disadvantages – pros/cons)@CritCareReviewshttps://t.co/kjCw7dFuou pic.twitter.com/xS9lHK4cuY— Intens Care Med (@yourICM) December 2, 2021
Estudo randomizado | Cirurgia citorredutora para recidiva de câncer de ovário.
2 Dez, 2021 | 11:19hOutro estudo randomizado mostrou que o plasma convalescente não beneficia pacientes internados com Covid-19.
1 Dez, 2021 | 15:36hConteúdos relacionados:
M-A: Convalescent plasma does not reduce mortality in COVID-19.
M-A: Convalescent plasma is safe but does not improve outcomes in the treatment of COVID-19.
RECOVERY Trial: No benefit from convalescent plasma in patients admitted to hospital with COVID-19.
Comentário no Twitter
The TSUNAMI RCT showed that high-titer convalescent plasma (CP) did not reduce the risk of severe respiratory failure or death in hospitalized patients with #COVID19 pneumonia. https://t.co/4q0S2AtfMj
— JAMA Network Open (@JAMANetworkOpen) November 29, 2021
Estudo randomizado fase II | Eficácia e segurança do itepequimabe em pacientes com asma moderada a grave.
26 Nov, 2021 | 11:41hEfficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma – New England Journal of Medicine (link para o resumo – $ para o texto completo)
Comentários no Twitter
Visual Abstract: Efficacy and Safety of Itepekimab for Moderate-to-Severe Asthma https://t.co/7mldcsSaeW pic.twitter.com/RlvE2Z1Tas
— NEJM (@NEJM) November 3, 2021
In this randomized trial, the monoclonal antibody itepekimab against interleukin-33 improved asthma control in patients with moderate-to-severe asthma. https://t.co/8yNcYumImy pic.twitter.com/YmMP0HjRvA
— NEJM (@NEJM) October 28, 2021