Estudos Randomizados
Estudo randomizado | Aumento da imunidade com timosina alfa-1 não melhora os desfechos em pacientes com pancreatite necrotizante aguda grave prevista.
21 Jun, 2022 | 12:45hImmune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double-blind randomised controlled trial – Intensive Care Medicine (se o acesso a este link for pago, tente este)
Estudo randomizado | Segurança e eficácia do eptinezumabe para prevenção de enxaqueca em pacientes com 2 a 4 tratamentos preventivos prévios falhos.
21 Jun, 2022 | 12:40hSafety and efficacy of eptinezumab for migraine prevention in patients with two-to-four previous preventive treatment failures (DELIVER): a multi-arm, randomised, double-blind, placebo-controlled, phase 3b trial – The Lancet Neurology (link para o resumo – $ para o texto completo)
#CCR22 – Estudo randomizado | Vitamina C intravenosa aumenta o risco de morte ou disfunção persistente de órgão em adultos com sepse em UTI.
19 Jun, 2022 | 17:03hConteúdos relacionados:
Comentário no Twitter
In this trial of IV vitamin C in adult patients with sepsis, those who received a vitamin C infusion had a higher risk of death or persistent organ dysfunction at 28 days than those who received placebo. #CCR22 https://t.co/8tpW7Yud6a pic.twitter.com/1Jf9aIka8Y
— NEJM (@NEJM) June 15, 2022
Estudo randomizado | Descontinuação da terapia com infliximabe em pacientes com doença de Crohn.
19 Jun, 2022 | 15:29hDiscontinuation of Infliximab Therapy in Patients with Crohn’s Disease – NEJM Evidence
Estudo randomizado | Suplementação de ácido graxo ômega 3 de origem marinha não reduz a incidência de olho seco em adultos saudáveis.
16 Jun, 2022 | 14:00hEfficacy of Marine ω-3 Fatty Acid Supplementation vs Placebo in Reducing Incidence of Dry Eye Disease in Healthy US Adults: A Randomized Clinical Trial – JAMA Ophthalmology (gratuito por tempo limitado)
Comentário convidado: Another Disappointment for ω-3 Fatty Acid and Dry Eye Disease – JAMA Ophthalmology (gratuito por tempo limitado)
Comentário no Twitter
In this randomized clinical trial, daily supplementation with marine omega-3 fatty acids (1 gram) for a median of 5.3 years had no significant effect on the incidence of diagnosed #dryeyedisease (DED) or reported DED symptoms. https://t.co/iTBONh6CZK
— JAMAOphthalmology (@JAMAOphth) June 9, 2022
Estudo de acurácia diagnóstica | Medida da circunferência do pescoço para vigilância e detecção precoce de hemorragia após tireoidectomia.
16 Jun, 2022 | 13:44hNeck Circumference Measurement for Surveillance and Early Detection of Hemorrhage After Thyroidectomy: A Diagnostic Accuracy Study – JAMA Otolaryngology-Head & Neck Surgery (gratuito por tempo limitado)
Comentário no Twitter
Study evaluated neck circumference measurements as a diagnostic tool to improve patient’s safety in thyroid surgery. An increase of 7% or more seemed to be specific for post-thyroidectomy hemorrhage along with other clinical signs. https://t.co/HQqjv3svRx #thyroidectomy
— JAMA Otolaryngology – Head & Neck Surgery (@JAMAOto) June 9, 2022
Estudo randomizado | Efeito do monitoramento eletrônico de sintomas nos desfechos relatados pelo paciente naqueles com câncer metastático.
14 Jun, 2022 | 14:03hEffect of Electronic Symptom Monitoring on Patient-Reported Outcomes Among Patients With Metastatic Cancer: A Randomized Clinical Trial – JAMA (gratuito por tempo limitado)
Conteúdos relacionados:
Digital remote monitoring plus usual care versus usual care in patients treated with oral anticancer agents: the randomized phase 3 CAPRI trial – Nature Medicine (se o acesso a este link for pago, tente este)
Key components of successful digital remote monitoring in oncology – Nature Medicine
É preciso reconsiderar como são planejados e conduzidos os estudos controlados randomizados?
14 Jun, 2022 | 13:46hEstudo randomizado | Efeito de transferências intraoperatórias de cuidados anestésicos sobre mortalidade, reinternação e complicações pós-cirúrgicas entre adultos.
13 Jun, 2022 | 14:35hEffect of Intraoperative Handovers of Anesthesia Care on Mortality, Readmission, or Postoperative Complications Among Adults: The HandiCAP Randomized Clinical Trial – JAMA (gratuito por tempo limitado)
Estudo relacionado: Association Between Handover of Anesthesia Care and Adverse Postoperative Outcomes Among Patients Undergoing Major Surgery – JAMA
Comentário no Twitter
In this RCT, among adults undergoing extended surgical procedures, there was no difference bw handover of anesthesia care compared w no handover of care in the primary outcome of mortality, readmission, & serious postoperative complications within 30 days.https://t.co/FpGFZk47x7
— JAMA (@JAMA_current) June 4, 2022