Estudos Randomizados

Estudo randomizado | Eficácia e segurança da viloxazina em cápsulas de liberação prolongada para adultos com transtorno de déficit de atenção/hiperatividade.

2 Ago, 2022 | 13:01h

A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Efficacy and Safety of Viloxazine Extended-Release Capsules in Adults with Attention-Deficit/Hyperactivity Disorder – CNS Drugs

 

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Estudo randomizado | Tixagevimabe-cilgavimabe para tratamento de pacientes internados com COVID-19.

18 Jul, 2022 | 13:36h

Tixagevimab–cilgavimab for treatment of patients hospitalised with COVID-19: a randomised, double-blind, phase 3 trial – The Lancet Respiratory Medicine

Comentário: The potential of tixagevimab–cilgavimab for treating hospitalized COVID-19 patients – News Medical

Conteúdos relacionados:

Efficacy and safety of intramuscular administration of tixagevimab–cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trial – The Lancet Respiratory Medicine

Intramuscular AZD7442 (Tixagevimab–Cilgavimab) for Prevention of Covid-19 – New England Journal of Medicine

 

Comentário no Twitter

In pts hospitalised w/ COVID-19 receiving remdesivir and other standard care, tixagevimab–cilgavimab did not improve time to sustained recovery but was safe and mortality was lower vs placebo

From the ACTIV-3–TICO Study Group https://t.co/zaaXBQYl5t pic.twitter.com/xe0tmbFrZ9

— The Lancet Respiratory Medicine (@LancetRespirMed) July 11, 2022

 

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Estudo randomizado | Deucravacitinibe vs. placebo vs. apremilaste na psoríase em placas moderada a grave.

18 Jul, 2022 | 13:14h

Deucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: efficacy and safety results from the 52-week, randomized, double-blinded, placebo-controlled phase 3 POETYK PSO-1 trial – Journal of the American Academy of Dermatology (link para o resumo – $ para o texto completo)

 

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Revisão sistemática de escopo | Estudos randomizados na saúde materna e perinatal em países de baixa e média rendas de 2010 a 2019.

18 Jul, 2022 | 13:09h

Randomised trials in maternal and perinatal health in low and middle-income countries from 2010 to 2019: a systematic scoping review – BMJ Open

 

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Estudo randomizado | Teste farmacogenômico para interações medicamento-genes fornece pouco benefício à remissão de sintomas no transtorno depressivo maior.

18 Jul, 2022 | 13:04h

Effect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial – JAMA (gratuito por tempo limitado)

Editorial: Pharmacogenomic Testing for Next-Step Antidepressant Selection: Still a Work in Progress – JAMA (gratuito por tempo limitado)

Comentário: Does Pharmacogenomic Testing Improve Outcomes in Major Depressive Disorder? — The evidence is unclear – MedPage Today (necessário cadastro gratuito)

 

Comentário no Twitter

In this randomized clinical trial, pharmacogenomic testing for drug-gene interactions in major depressive disorder reduced prescription of medications with predicted drug-gene interactions but had small and nonpersistent effects on symptom remission. https://t.co/Z2OIK3h1Bo pic.twitter.com/8eKSipfBFN

— JAMA (@JAMA_current) July 12, 2022

 

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Estudo randomizado | Eritropoietina não traz benefício à encefalopatia hipóxico-isquêmica em recém-nascidos.

18 Jul, 2022 | 12:48h

Trial of Erythropoietin for Hypoxic–Ischemic Encephalopathy in Newborns – New England Journal of Medicine (link para o resumo – $ para o texto completo)

 

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Estudo randomizado transversal | Inteligência artificial (IA) reduz a taxa de falha no achado de pólipos pré-cancerosos no rastreamento de câncer colorretal.

18 Jul, 2022 | 12:41h

Comunicado de imprensa: AI reduces miss rate of precancerous polyps in colorectal cancer screening – Mayo Clinic

Estudo original: Impact of Artificial Intelligence on Miss Rate of Colorectal Neoplasia – Gastroenterology

 

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Estudo randomizado | Efeitos da técnica de ponto curto para fechamento abdominal em linha média na hérnia incisional.

18 Jul, 2022 | 12:39h

Effects of the Short Stitch Technique for Midline Abdominal Closure on Incisional Hernia (ESTOIH): Randomized Clinical Trial – British Journal of Surgery

 

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Estudo randomizado | Efeito da injeção de corticosteroide guiada por ultrassonografia vs. placebo adicionada a fisioterapia para tendinopatia do calcâneo (tendão de Aquiles).

18 Jul, 2022 | 12:35h

Effect of Ultrasonography-Guided Corticosteroid Injection vs Placebo Added to Exercise Therapy for Achilles Tendinopathy: A Randomized Clinical Trial – JAMA Network Open

Comentário: Trial Backs Steroid Shots for Stubborn Achilles Tendon Pain — Corticosteroid bests placebo when combined with resistance exercise therapy – MedPage Today (necessário cadastro gratuito)

 

Comentário no Twitter

In this RCT, corticosteroid injections + exercise therapy was more effective for patients with long-standing Achilles tendinopathy compared to placebo injections + exercise therapy. https://t.co/nkTH0OYL4a

— JAMA Network Open (@JAMANetworkOpen) July 11, 2022

 

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Estudo randomizado | Inibição de miosina em pacientes com cardiomiopatia hipertrófica obstrutiva encaminhados para terapia de redução de septo.

14 Jul, 2022 | 12:02h

Myosin Inhibition in Patients With Obstructive Hypertrophic Cardiomyopathy Referred for Septal Reduction Therapy – Journal of the American College of Cardiology

Conteúdo relacionado: #ACC22 [Not published yet] – RCT: Mavacamten reduces the need for surgical intervention in patients with obstructive hypertrophic cardiomyopathy.

 

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