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Opinião | Cannabis medicinal para dor crônica: o triângulo das Bermudas dos estudos de baixa qualidade, incontáveis metanálises e recomendações conflitantes.

6 Abr, 2022 | 12:49h

Medicinal Cannabis for Chronic Pain: The Bermuda Triangle of Low Quality Studies, Countless Meta-analyses and Conflicting Recommendations – European Journal of Pain

Conteúdos relacionados:

RCT: Effect of medical marijuana card ownership on pain, insomnia, and affective disorder symptoms in adults.

Cohort Study: Long-term cannabis use is associated with cognitive deficits and smaller hippocampal volume in midlife.

AHA Scientific Statement | How does cannabis use affect brain health? Caution advised, more research needed.

M-A: Birth outcomes of neonates exposed to marijuana in utero.

Cannabis-related allergies: an international overview and consensus recommendations.

Review: Cannabis-based medicines and medical cannabis for chronic neuropathic pain.

Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions.

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain.

The International Cannabis Toolkit (iCannToolkit): a multidisciplinary expert consensus on minimum standards for measuring cannabis use.

Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.

Guideline: Medical cannabis or cannabinoids for chronic pain.

Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.”

NICE Guideline: Cannabis-Based Medicinal Products

Consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Short Review: Drug Interactions with Cannabinoids

Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain

Review: Considerations for cannabinoids in perioperative care by anesthesiologists.

Review: Cannabis-based Medicines and the Perioperative Physician

Study: Cannabis Use Disorder May Increase the Risk of Cardiovascular Events in Major Elective Surgeries

Perspective: If You Smoke Pot, Your Anesthesiologist Needs To Know

Perioperative Care of Cannabis Users: A Comprehensive Review of Pharmacological and Anesthetic Considerations

Estudo randomizado | Eficácia, segurança e imunogenicidade da vacina de DNA contra SARS-CoV-2 (ZyCoV-D).

6 Abr, 2022 | 12:48h

Efficacy, safety, and immunogenicity of the DNA SARS-CoV-2 vaccine (ZyCoV-D): the interim efficacy results of a phase 3, randomised, double-blind, placebo-controlled study in India – The Lancet

Comentário convidado: DNA vaccines join the fight against COVID-19 – The Lancet

 

Comentário no Twitter

 

Estudo de coorte | Mudança nas taxas de mortalidade por doença cardíaca e AVC antes e durante a pandemia de Covid-19.

6 Abr, 2022 | 12:46h

Age-Adjusted Mortality Rates and Age and Risk–Associated Contributions to Change in Heart Disease and Stroke Mortality, 2011-2019 and 2019-2020 – JAMA Network Open

Comentários:

Several-Fold Increase in Stroke and Heart Disease Deaths During COVID-19 Pandemic – NeurologyToday

2019 to 2020 Saw Risk-Linked Deaths From Heart Disease, Stroke Up – HealthDay

 

Comentário do autor no Twitter (fio – clique pra saber mais). Artigo e imagens sob CC-BY License

 

Estratégia da OMS para preparo, prontidão e plano de resposta para o fim da emergência global de Covid-19 em 2022.

5 Abr, 2022 | 12:30h

Strategic Preparedness, Readiness and Response Plan to End the Global COVID-19 Emergency in 2022 – World Health Organization

 

Comentário no Twitter (fio – clique para saber mais)

 

#ACC22 | Diretriz 2022 AHA/ACC/HFSA para tratamento de insuficiência cardíaca.

5 Abr, 2022 | 12:28h

Diretriz ACC: Heart Failure

2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines – Journal of the American College of Cardiology

Resumo executivo: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure

Comunicado de imprensa: ACC, AHA, HFSA Issue Heart Failure Guideline – American Heart Association

Principais perspectivas: 2022 AHA/ACC/HFSA Heart Failure Guideline

Download de série de slides: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure

Flipbook

 

Comentário no Twitter

 

#ACC22 – Estudo randomizado | Ácido tranexâmico reduz o risco de sangramento em pacientes submetidos a cirurgia não cardíaca.

5 Abr, 2022 | 12:26h

Tranexamic Acid in Patients Undergoing Noncardiac Surgery – New England Journal of Medicine (link para o resumo – $ para o texto completo)

Comentários:

POISE-3: Tranexamic Acid Reduces Severe Bleeding Risk in Patients Undergoing Noncardiac Surgery – American College of Cardiology

POISE-3: Tranexamic Acid Stems Bleeding During Noncardiac Surgery – TCTMD

 

Comentários no Twitter

 

#ACC22 – Estudo randomizado | Tratamento para hipertensão crônica leve durante a gestação está associada com melhores desfechos gestacionais do que a estratégia de tratamento reservado somente para hipertensão grave.

5 Abr, 2022 | 12:25h

Treatment for Mild Chronic Hypertension during Pregnancy – New England Journal of Medicine (link para o resumo – $ para o texto completo)

Comentários:

Treating chronic hypertension in early pregnancy benefits parents, babies – NIH News Releases

CHAP: Treating Mild Chronic HTN is Associated With Better Pregnancy Outcomes – American College of Cardiology

CHAP: Better Blood Pressure Control, Better Pregnancy Outcomes – TCTMD

 

Comentário no Twitter

 

#ACC22 – Estudo randomizado | Entre pacientes ambulatoriais com insuficiência cardíaca, uma intervenção dietética para reduzir a ingestão de sódio não reduziu os eventos clínicos.

5 Abr, 2022 | 12:23h

Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial – The Lancet (necessário cadastro gratuito)

Comentários:

SODIUM-HF: No Impact of Dietary Salt Restriction on Death or Hospitalization – TCTMD

SODIUM-HF: Does Strictly Limiting Sodium Intake Reduce Cardiac Events, Improve QOL in HF Patients? – American College of Cardiology

Hold the salt: Study reveals how reducing sodium intake can help patients with heart failure – University of Alberta

 

Comentário no Twitter

 

Pesquisadores geram a primeira sequência do genoma humano completa e sem falhas.

5 Abr, 2022 | 12:21h

Comunicado de imprensa: Researchers generate the first complete, gapless sequence of a human genome – NIH News Releases

Estudo original: The complete sequence of a human genome – Science

Comentários:

Scientists sequence the complete human genome for the first time – CNN

First complete gap-free human genome sequence published – The Guardian

Scientists finally finish decoding entire human genome – Associated Press

Segurança, tolerabilidade e cinética viral durante o desafio do SARS-CoV-2 humano em adultos jovens (infectando indivíduos deliberadamente em ambiente controlado).

5 Abr, 2022 | 12:20h

Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults – Nature Medicine

Comentários:

Understanding COVID-19 through human challenge models – Nature Medicine

First human challenge study of Covid-19 yields valuable insights about how we get sick – CNN

First Human Challenge Trial Shows How COVID-19 Strikes – HealthDay

Conteúdos relacionados:

Scientists deliberately gave people COVID — here’s what they learnt.

[Preprint] Results from the first Covid-19 human challenge study (deliberately infecting individuals in a controlled environment).

Perspective | SARS-CoV-2 human challenge studies — establishing the model during an evolving pandemic.

World’s first coronavirus “Human Challenge” study receives ethics approval in the UK  (vários textos sobre o assunto)

Are SARS-CoV-2 Human Challenge Trials Ethical? – “A clinical trial is underway in the UK in which young, healthy participants are exposed deliberately to SARS-CoV-2 to assess the viral inoculum needed to produce an infection and to test vaccine efficacy”.

 

Comentário no Twitter

 

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