Destaques

Estudo randomizado | Efeito de traqueostomia precoce vs. tratamento padrão sobre o desfecho funcional de 6 meses em pacientes com AVC grave sob ventilação mecânica.

10 Mai, 2022 | 12:41h

Effect of Early vs Standard Approach to Tracheostomy on Functional Outcome at 6 Months Among Patients With Severe Stroke Receiving Mechanical Ventilation: The SETPOINT2 Randomized Clinical Trial – JAMA (gratuito por tempo limitado)

 

Comentário no Twitter

In this study, among patients with severe stroke receiving mechanical ventilation, a strategy of early tracheostomy, compared with a standard approach to tracheostomy, did not significantly improve functional outcome at 6 months. https://t.co/bLZ4b6hBxr

— JAMA (@JAMA_current) May 4, 2022

 

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Estudo randomizado | Prevenção secundária de longo prazo de doença cardiovascular com dieta mediterrânea vs. dieta pobre em gorduras.

10 Mai, 2022 | 12:40h

Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial – The Lancet (link para o resumo – $ para o texto completo)

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COVID longa: visando a um consenso.

10 Mai, 2022 | 12:38h

Long COVID: aiming for a consensus – The Lancet Respiratory Medicine

 

Comentário no Twitter

There is an urgent need for unification of terminology for the sequelae of #SARSCoV2 infection to ensure that research is directed towards and translated into interventional trials to improve outcomes

NEW Comment—#LongCOVID: aiming for a consensushttps://t.co/dZO4rBVCSY pic.twitter.com/H5ezqL0RLb

— The Lancet Respiratory Medicine (@LancetRespirMed) May 5, 2022

 

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Revisão | Patogênese do SARS-CoV-2.

10 Mai, 2022 | 12:37h

SARS-CoV-2 pathogenesis – Nature Reviews Microbiology

 

Comentário no Twitter

A Review published in @NatureRevMicro explores recent clinical and experimental advances in understanding SARS-CoV-2 pathogenesis, interactions with host cells and the involvement of the immune system in the development of severe disease. https://t.co/GTm0BZ3ikH pic.twitter.com/jPXFU05Pwm

— Nature Portfolio (@NaturePortfolio) April 23, 2022

 

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Revisão sistemática e metanálise de estudos randomizados controlados e estudos de coorte | Segurança do ezetimibe no tratamento de redução de lipídios.

10 Mai, 2022 | 12:36h

Safety of ezetimibe in lipid-lowering treatment: systematic review and meta-analysis of randomised controlled trials and cohort studies – BMJ Medicine

Conteúdos relacionados:

PCSK9 inhibitors and ezetimibe for the reduction of cardiovascular events: a clinical practice guideline with risk-stratified recommendations – The BMJ

PCSK9 inhibitors and ezetimibe with or without statin therapy for cardiovascular risk reduction: a systematic review and network meta-analysis – The BMJ

 

Comentário no Twitter

Read a new #systematicreview and meta-analysis of RCTs and cohort studies on the safety of #Ezetimibe in lipid-lowering treatment. ▶️ https://t.co/mr4H5MfVdP#VisualAbstract #RapidRecommendations@bmj_latest @theMAGICapp pic.twitter.com/OLg0HZr8D3

— BMJMedicine (@BMJMedicine) May 5, 2022

 

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10 dicas para melhorar o uso de vasopressores em pacientes críticos hipotensos.

6 Mai, 2022 | 17:46h

Ten tips to optimize vasopressors use in the critically ill patient with hypotension – Intensive Care Medicine (se o acesso a este link for pago, tente este)

 

Comentário no Twitter

Vasopressors in #ICU
1️⃣set MAP/DBP goals
2️⃣individualize
3️⃣may⬇️+ve fluid balance
4️⃣reassess fluid status/CO
5️⃣change mechanism as 2 line
6️⃣high doses?? hydrocortisone
7️⃣vasopressin in RV failure
8️⃣no MAX dose
9️⃣EN can be initiated
🔟can be safe in PVC
🖇 https://t.co/v6Q9nfy5KY pic.twitter.com/8YEDaOQBOQ

— Intensive Care Medicine (@yourICM) May 4, 2022

 

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Diretriz de prática clínica com recomendações estratificadas pelo risco | Inibidores de PCSK9 e ezetimibe para redução de eventos cardiovasculares.

6 Mai, 2022 | 17:45h

PCSK9 inhibitors and ezetimibe for the reduction of cardiovascular events: a clinical practice guideline with risk-stratified recommendations – The BMJ

Ver também: PCSK9 inhibitors and ezetimibe with or without statin therapy for cardiovascular risk reduction: a systematic review and network meta-analysis – The BMJ

Comunicado de imprensa: Experts recommend additional cholesterol lowering drugs for adults at high heart disease risk – British Medical Journal

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Estudo de coorte transversal | Variação no uso da revascularização e desfechos de pacientes internados com infarto agudo do miocárdio em 6 países de alta renda.

6 Mai, 2022 | 17:43h

Variation in revascularisation use and outcomes of patients in hospital with acute myocardial infarction across six high income countries: cross sectional cohort study – The BMJ

Comunicado de imprensa: Study finds large differences in heart attack care across six high income countries – British Medical Journal

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Estudo de efetividade comparativa | Oxigenação extracorpórea venovenosa em pacientes com insuficiência respiratória associada a Covid-19 aguda.

6 Mai, 2022 | 17:42h

Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness study – The BMJ

 

Comentário no Twitter

In this international, registry based cohort study of patients with covid-19 associated acute respiratory failure, extracorporeal membrane oxygenation was associated with a reduction in mortality by 7.1% compared with conventional mechanical ventilation https://t.co/VkNFeRDQ3j

— The BMJ (@bmj_latest) May 4, 2022

 

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Descartados os suspeitos comuns (Hepatites A-E), cientistas tentam desvendar o mistério dos casos de hepatite viral em crianças.

6 Mai, 2022 | 17:41h

With usual suspects ruled out, disease detectives try to crack mystery of viral hepatitis cases in kids – STAT

Conteúdos relacionados:

Acute Hepatitis and Adenovirus Infection Among Children — Alabama, October 2021–February 2022 – Morbidity and Mortality Weekly Report

The CDC and WHO Have Reported an Unusual Cluster of Severe Pediatric Hepatitis Cases – Science-Based Medicine

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing – UK Health Security Agency

Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization

WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT

CDC Alerts Providers to Hepatitis Cases of Unknown Origin – Centers for Disease Control and Prevention

Recommendations for Adenovirus Testing and Reporting of Children with Acute Hepatitis of Unknown Etiology – Centers for Disease Control and Prevention

Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch

Increase in hepatitis (liver inflammation) cases in children under investigation – UK Health Security Agency

U.S., U.K. investigating unusual cases of hepatitis in young children – STAT

Acute hepatitis of unknown aetiology – the United Kingdom of Great Britain and Northern Ireland – World Health Organization

Increase in acute hepatitis of unknown origin among children – United Kingdom – European Centre for Disease Prevention and Control

Mysterious liver illness seen in kids in US, Europe – Associated Press

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