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Recomendações de consenso | Atividades prioritárias para abordar a lesão renal aguda em crianças.

4 Out, 2022 | 12:37h

Consensus-Based Recommendations on Priority Activities to Address Acute Kidney Injury in Children: A Modified Delphi Consensus Statement – JAMA Network Open

Comentário convidado: Highlights of Consensus-Based Recommendations for Acute Kidney Injury in Children – JAMA Network Open

 

Comentário no Twitter

 

M-A de estudos randomizados | Colchicina e riscos de doença cardíaca coronariana.

4 Out, 2022 | 12:36h

Colchicine and coronary heart disease risks: A meta-analysis of randomized controlled clinical trials – Frontiers in Cardiovascular Medicine

Conteúdos relacionados:

M-A: Colchicine after percutaneous coronary intervention significantly reduces the risk of major adverse cardiovascular events in patients with symptomatic coronary artery disease.

Expert Analysis | Colchicine in acute coronary syndrome: when to commence?

M-A: Colchicine in patients with coronary artery disease – “colchicine reduces the risk of myocardial infarction and stroke, but has a higher rate of gastrointestinal upset with no influence on all‐cause mortality”.

Review: Colchicine and the heart.

M-A: Colchicine administration for percutaneous coronary intervention

M-A: Efficacy and safety of low-dose colchicine in patients with coronary disease

Meta-analysis: Colchicine reduces new cardiovascular events in patients with coronary artery disease

Expert analysis: Efficacy and safety of colchicine in patients with chronic stable coronary disease

#ESCCongress – [Abstract Only] Randomized trial: Colchicine in patients with chronic coronary disease

#ESCCongress – Randomized trial: Colchicine not beneficial for patients with acute coronary syndrome

#ESCCongress – Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT)

#AHA19 – [Abstract Only] Practice Changing? – Randomized Trial: Low-Dose Colchicine Improves Outcomes after Myocardial Infarction

Research: Colchicine Therapy and Plaque Stabilization in Patients With Acute Coronary Syndrome

 

Estudo randomizado | Hipotermia induzida não melhorou a sobrevida ou os desfechos funcionais após parada cardíaca em ambiente hospitalar.

3 Out, 2022 | 12:58h

Temperature Control After In-Hospital Cardiac Arrest: A Randomized Clinical Trial – Circulation (gratuito por tempo limitado)

Conteúdos relacionados:

Hypothermic versus Normothermic Temperature Control after Cardiac Arrest – NEJM Evidence

ERC-ESICM guidelines on temperature control after cardiac arrest in adults – Intensive Care Medicine (se o acesso a este link for pago, tente este)

Target temperature management following cardiac arrest: a systematic review and Bayesian meta-analysis – Critical Care

Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets – Intensive Care Medicine

Targeted Temperature Management for Cardiac Arrest Due to Non-shockable Rhythm: A Systematic Review and Meta-Analysis of Randomized Controlled Trials – Frontiers in Medicine

Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The CAPITAL CHILL Randomized Clinical Trial – JAMA

Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest – New England Journal of Medicine

 

Comentário no Twitter

 

Estudo randomizado | Não há benefício do uso de hidrocortisona, vitamina C e tiamina em pacientes adultos com choque séptico.

3 Out, 2022 | 12:56h

Early administration of hydrocortisone, vitamin C, and thiamine in adult patients with septic shock: a randomized controlled clinical trial – Critical Care

Conteúdos relacionados:

Parenteral Vitamin C in Patients with Severe Infection: A Systematic Review – NEJM Evidence

Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit – New England Journal of Medicine

Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis – Intensive Care Medicine

Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial – JAMA

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial – JAMA

 

Recomendações práticas | Como lidar com problemas do sono durante ondas de calor?

13 Set, 2022 | 12:12h

How to deal with sleep problems during heatwaves: practical recommendations from the European Insomnia Network – Journal of Sleep Research

Comentário: How to sleep in a heat wave, according to experts – CNN

 

Estudo randomizado | Em pacientes com queimaduras graves, a suplementação de glutamina não melhorou os desfechos.

13 Set, 2022 | 12:11h

A Randomized Trial of Enteral Glutamine for Treatment of Burn Injuries – New England Journal of Medicine (link para o resumo – $ para o texto completo)

 

Comentário no Twitter

 

Estudo randomizado | Em jovens com diabetes tipo 1 de início recente, o controle glicêmico intensivo por 24 meses com sistema de circuito fechado não ajudou a preservar a função pancreática.

13 Set, 2022 | 12:10h

Closed-Loop Therapy and Preservation of C-Peptide Secretion in Type 1 Diabetes – New England Journal of Medicine (link para o resumo – $ para o texto completo)

Comentários:

MedH researcher on new study on preserved insulin production in type 1 diabetes – Karolinska Institutet

Preservation of C-Peptide Secretion Examined in Youth With T1D – HealthDay

 

Comentário no Twitter (resumo em vídeo)

 

Dois grandes estudos clínicos mostraram que suplementos de vitamina D não reduzem o risco de Covid-19.

13 Set, 2022 | 12:08h

Estudo 1: Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT) – The BMJ

Estudo 2: Prevention of covid-19 and other acute respiratory infections with cod liver oil supplementation, a low dose vitamin D supplement: quadruple blinded, randomised placebo controlled trial – The BMJ

Editorial: Can vitamin D protect against covid-19? – The BMJ

Comunicado de imprensa: No link between vitamin D supplements and reduced risk of covid-19 – BMJ Newsroom

 

Estudo de coorte mostrou uma possível ligação entre adoçantes artificiais e doença cardíaca.

13 Set, 2022 | 12:07h

Comunicado de imprensa: Possible link between artificial sweeteners and heart disease – BMJ Newsroom

Estudo original: Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort – The BMJ

 

Varíola dos macacos: epidemiologia da doença, imunidade do hospedeiro e intervenções clínicas.

13 Set, 2022 | 12:05h

Monkeypox: disease epidemiology, host immunity and clinical interventions – Nature Reviews Immunology

 

Comentário no Twitter

 

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