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Critérios de classificação ACR/EULAR 2022 para granulomatose com poliangiíte.

4 Fev, 2022 | 17:26h

2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for granulomatosis with polyangiitis – Annals of Rheumatic Diseases (link para o resumo – $ para o texto completo)

 

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Critérios de classificação ACR/EULAR 2022 para granulomatose eosinofílica com poliangiíte.

4 Fev, 2022 | 17:25h

2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis with Polyangiitis – Annals of Rheumatic Diseases (link para o resumo – $ para o texto completo)

 

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Diretriz de consenso | Manejo pré-operatório das medicações para doenças psiquiátricas.

4 Fev, 2022 | 16:54h

Preoperative Management of Medications for Psychiatric Diseases: Society for Perioperative Assessment and Quality Improvement Consensus Statement – Mayo Clinic Proceedings

Perspectiva | Desafios de inferir a gravidade intrínseca da variante Ômicron do SARS-CoV-2.

4 Fev, 2022 | 16:53h

Challenges in Inferring Intrinsic Severity of the SARS-CoV-2 Omicron Variant – New England Journal of Medicine (link para o resumo – $ para o texto completo)

 

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[Preprint] Variante Ômicron do vírus SARS-CoV-2 causa doença atenuada em ratos e hamsters.

4 Fev, 2022 | 16:52h

SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters – Nature

Ver também: [Preprint] Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron – Nature

Comentário: Omicron causes less severe illness in animal models than previous variants – University of Wisconsin–Madison

 

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[Preprint] Resultados do primeiro “challenge study” sobre Covid-19 em humanos (infectar indivíduos deliberadamente em um ambiente controlado).

4 Fev, 2022 | 16:50h

Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge – Research Square

Comentários:

Scientists deliberately gave people COVID — here’s what they learnt – Nature

Expert reaction to a preprint looking at the course of SARS-CoV-2 infection in a COVID-19 human challenge study – Science Media Centre

First COVID-19 human challenge study yields infection clues – CIDRAP

Exposure to one nasal droplet enough for Covid infection – study – The Guardian

Conteúdos relacionados:

Perspective | SARS-CoV-2 human challenge studies — establishing the model during an evolving pandemic.

World’s first coronavirus “Human Challenge” study receives ethics approval in the UK  (vários textos sobre o tema)

Are SARS-CoV-2 Human Challenge Trials Ethical? – “A clinical trial is underway in the UK in which young, healthy participants are exposed deliberately to SARS-CoV-2 to assess the viral inoculum needed to produce an infection and to test vaccine efficacy”.

Estudo randomizado | Em pacientes com carcinoma esofágico de células escamosas avançado, tanto o nivolumabe com quimioterapia quanto o nivolumabe com ipilimumabe resultaram em sobrevida geral mais longa do que a quimioterapia isolada.

4 Fev, 2022 | 16:48h

Nivolumab Combination Therapy in Advanced Esophageal Squamous-Cell Carcinoma – New England Journal of Medicine (link para o resumo – $ para o texto completo)

Comentário (Reunião anual da ASCO 2021): Nivolumab Plus Chemotherapy and Nivolumab Plus Ipilimumab as First-Line Treatment for Patients With Advanced Esophageal Cancer – The ASCO Post

 

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Estudo de coorte | Em ambientes de alta transmissão, o uso de redes de proteção contra o mosquito transmissor da malária durante a primeira infância foi associado com aumento da sobrevida décadas depois.

4 Fev, 2022 | 16:47h

Mosquito Net Use in Early Childhood and Survival to Adulthood in Tanzania – New England Journal of Medicine

Comentários:

Malaria-preventing bed nets save children’s lives—with impacts that can last for decades – Science

Mosquito nets in young children save lives into adulthood – University of Basel

Variante “irmã” da Ômicron se dissemina mais rápido. Então, por que a chamada Ômicron nos afetou primeiro?

4 Fev, 2022 | 16:46h

Omicron’s sister variant spreads faster. So why did the one we call Omicron hit first? – STAT

Conteúdos relacionados:

[Preprint] Study suggests SARS-CoV-2 Omicron subvariants BA.2 is even more transmissible than the original variant.

BA.2 is like Omicron’s sister. Here’s what we know about it so far – The Conversation

Estudo randomizado e controlado por cluster | Uma rede inovadora de telemedicina para melhorar o tratamento de doenças infecciosas em pacientes críticos e ambulatoriais.

4 Fev, 2022 | 16:45h

An innovative telemedical network to improve infectious disease management in critically ill patients and outpatients: a stepped-wedge, cluster randomized controlled trial (TELnet@NRW) – Journal of Medical Internet Research

Conteúdos relacionados:

The “Choosing Wisely” initiative in infectious diseases – German Society of Infectious Diseases (link para o resumo – $ para o texto completo)

Infectious Diseases Society of America: Five Things Physicians and Patients Should Question

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