Destaques

[Preprint] Risco de morte após infecção pelo SARS-CoV-2 ou vacinação contra COVID-19 em jovens na Inglaterra.

25 Mar, 2022 | 15:59h

Risk of death following SARS-CoV-2 infection or COVID-19 vaccination in young people in England: a self-controlled case series study – medRxiv

 

Comentário no Twitter

Pleased to share our study showing that there is no evidence of an increased risk of death in young people after COVID-19 vaccination in England

Great collaboration with @kamleshkhunti @amibanerjee1 and others not on twitter!https://t.co/EV4xmDWeyB pic.twitter.com/VQy2PtCxeC

— Vahé Nafilyan (@Vnafilyan) March 24, 2022

 

---

Os lockdowns contra COVID funcionam? Isto é o que se sabe depois de 2 anos.

25 Mar, 2022 | 15:58h

Did the COVID lockdowns work? Here’s what we know two years on – The Conversation

Conteúdos relacionados:

M-A: Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality.

Is the cure really worse than the disease? The health impacts of lockdowns during COVID-19 – “While there are certainly costs to be expected from intervening against COVID-19—every decision has a cost, after all—the counterfactual of an unmitigated epidemic makes these restrictions far less damaging than some have suggested”.

---

[Preprint] Efetividade de 2 e 3 doses de vacinas Pfizer e CoronaVac contra COVID-19 em Hong Kong.

25 Mar, 2022 | 15:56h

Vaccine effectiveness of two and three doses of BNT162b2 and CoronaVac against COVID-19 in Hong Kong – medRxiv

 

Comentário no Twitter

New data from Hong Kong on Coronavac and Pfizer vaccines implicates lack of vaccination and boosters in people of advanced age, not type of vaccine, for extreme fatality rates.
2 doses: Coronavac less protective than Pfizer
3 doses: equivalent VEhttps://t.co/BSOGscPvmc pic.twitter.com/UZqYhN7zP5

— Eric Topol (@EricTopol) March 23, 2022

 

---

Estudo randomizado | Entre prematuros com idade gestacional menor que 30 semanas e entubados por pelo menos 7 e nascidos de 14 a 28 dias, hidrocortisona não melhorou a sobrevida sem displasia broncopulmonar.

25 Mar, 2022 | 15:03h

Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia – New England Journal of Medicine (link para o resumo – $ para o texto completo)

Ver também: Visual Abstract

Conteúdos relacionados:

Randomized Trial: Effect of Hydrocortisone on Mortality or Bronchopulmonary Dysplasia Among Very Preterm Infants Receiving Mechanical Ventilation

Systematic Review: Late (after 6 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.

Systematic Review: Early (started within six days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants.

State of the Art Review: Diagnosis and management of bronchopulmonary dysplasia.

M-A: Assessment of postnatal corticosteroids for the prevention of bronchopulmonary dysplasia in preterm neonates

ERS Guideline on Long-term Management of Children with Bronchopulmonary Dysplasia

 

Comentário no Twitter

In this trial involving preterm infants, there was little difference in survival without bronchopulmonary dysplasia or in the occurrence of neurodevelopmental impairment with hydrocortisone as compared with placebo. https://t.co/wzGQ1gohjA pic.twitter.com/yfrIaG3JLv

— NEJM (@NEJM) March 23, 2022

 

---

Estudo randomizado | Tratamento com dose única de anfotericina B lipossomal para meningite por criptococo.

25 Mar, 2022 | 15:01h

Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis – New England Journal of Medicine (link para o resumo – $ para o texto completo)

 

Comentário no Twitter

Cryptococcal meningitis is a major complication of HIV infection. Single-dose liposomal amphotericin B combined with flucytosine and fluconazole was noninferior to the WHO-recommended treatment and was associated with fewer adverse events. https://t.co/cg9DqSDhyN pic.twitter.com/SrKx4tDaph

— NEJM (@NEJM) March 23, 2022

 

---

Estudo observacional sugere que antieméticos antidopaminérgicos (domperidona, metopimazina e metoclopramida) estão associados com risco aumentado de AVC.

25 Mar, 2022 | 14:59h

Risk of first ischaemic stroke and use of antidopaminergic antiemetics: nationwide case-time-control study – The BMJ

Comunicado de imprensa: Widely used nausea drugs linked to heightened risk of stroke – BMJ

---

Estudo randomizado | Posição prona em pacientes não intubados não melhorou os desfechos em pacientes com hipoxemia moderada relacionada à Covid-19.

25 Mar, 2022 | 14:58h

Prone positioning of patients with moderate hypoxaemia due to covid-19: multicentre pragmatic randomised trial (COVID-PRONE) – The BMJ

Editorial: Awake prone positioning for patients with covid-19

Comunicado de imprensa: Lying prone long enough to improve outcomes is difficult for many covid-19 patients – BMJ

---

Estudo randomizado | Segurança e eficácia da terceira dose de vacina da Pfizer contra Covid-19 durante a onda Delta.

25 Mar, 2022 | 14:56h

Safety and Efficacy of a Third Dose of BNT162b2 Covid-19 Vaccine – New England Journal of Medicine

 

Comentário no Twitter

A third dose of the BNT162b2 vaccine administered a median of 10.8 months after the second dose provided 95.3% efficacy against Covid-19 as compared with two doses. #COVID19 #IDTwitter https://t.co/IeHOgVhU8a pic.twitter.com/wValXSdyHX

— NEJM (@NEJM) March 23, 2022

 

---

Estudo de caso-controle | Efetividade da vacina da Pfizer contra COVID-19 em adolescentes.

25 Mar, 2022 | 14:55h

Effectiveness of BNT162b2 against COVID-19 in adolescents – The Lancet Infectious Diseases

 

Comentário no Twitter

Our paper on #COVID19 vaccine effectiveness in teenagers (12-17y) is published @TheLancetInfDis. Rapid waning of protection against symptomatic disease, esp with omicron. Vaccines did reduce delta hospitalisations but too early to assess omicron effects

👉https://t.co/1kkz7Ge9zf

— Shamez Ladhani (@ShamezLadhani) March 23, 2022

 

---

Revisão sistemática | Efetividade e segurança da oximetria de pulso no monitoramento remoto de pacientes com COVID-19.

25 Mar, 2022 | 14:54h

Effectiveness and safety of pulse oximetry in remote patient monitoring of patients with COVID-19: a systematic review – The Lancet Digital Health

Comentários:

Home blood oxygen monitoring can help COVID patients spot early warning signs – Imperial College London

Simple home oxygen monitors signal when to seek COVID care – CIDRAP

---