Destaques

In this cohort study of more than 330,000 children, less than 5% were labeled with penicillin allergy with wide variation across practices, with 8% of those labeled despite not receiving any penicillin prescription. https://t.co/kvXcm1RKRd

— JAMA Network Open (@JAMANetworkOpen) March 15, 2022

M-A | Comparação da efetividade das estatinas sobre o colesterol não HDL em pessoas com diabetes e risco de doença cardiovascular.

25 Mar, 2022 | 16:17h

Comparative effectiveness of statins on non-high density lipoprotein cholesterol in people with diabetes and at risk of cardiovascular disease: systematic review and network meta-analysis – The BMJ

Comunicado de imprensa: Best statins for reducing cardiovascular risk in people with diabetes found – University of Manchester

Comentário no Twitter

This network meta-analysis indicated that rosuvastatin, at moderate and high intensity doses, and simvastatin and atorvastatin, at high intensity doses, were most effective at moderately reducing levels of non-HDL-C in patients with diabeteshttps://t.co/NwUf4sX5KA

— The BMJ (@bmj_latest) March 24, 2022

Estudo randomizado | Entre pacientes com insuficiência cardíaca e fibrilação atrial, uma estratégia de controle de ritmo baseada em ablação não foi significativamente melhor do que a estratégia de controle de frequência para melhorar a mortalidade por todas as causas e os eventos de insuficiência cardíaca (HR 0,71; 95% IC 0,49-1,03; p = 0,066).

25 Mar, 2022 | 16:15h

Randomized Ablation-Based Rhythm-Control Versus Rate-Control Trial in Patients with Heart Failure and Atrial Fibrillation: Results from the RAFT-AF trial – Circulation

Conteúdos relacionados:

Update on management of atrial fibrillation in heart failure: a focus on ablation.

Review: Cryoballoon ablation as initial treatment for atrial fibrillation.

Subgroup analysis of RCT suggests early rhythm control therapy is beneficial for patients with atrial fibrillation and heart failure.

Meta-Analysis: Catheter Ablation Improves Outcomes in Patients with Atrial Fibrillation Complicated with Heart Failure

Catheter Ablation for Atrial Fibrillation Improves Outcomes in Heart Failure with Reduced Ejection Fraction

M-A: In patients with atrial fibrillation, catheter ablation was associated with a 38% reduction in recurrence and a 68% reduction in hospitalizations. The rate of serious complications was 4.2% with ablation vs. 2.8% in the antiarrhythmic group, a difference that was not statistically significant.

CABANATrial: Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation

Estudos mostram que é factível dar alta hospitalar no mesmo dia após substituição de válvula aórtica transcateter.

25 Mar, 2022 | 16:14h

Estudo 1: Same-Day Discharge Post–Transcatheter Aortic Valve Replacement During the COVID-19 Pandemic: The Multicenter PROTECT TAVR Study – JACC: Cardiovascular Interventions (link para o resumo – $ para o texto completo)

Estudo 2: Feasibility and Safety of Same-Day Discharge Following Transfemoral Transcatheter Aortic Valve Replacement – JACC: Cardiovascular Interventions (link para o resumo – $ para o texto completo)

Editorial: Did the COVID-19 Pandemic Just Turn TAVR Into an Outpatient Procedure?

Comentário: ‘Right Time, Right Moment’: Same-Day Discharge After TAVI Safe, Feasible – TCTMD

Coleção Especial Cochrane | Diagnóstico de tuberculose.

25 Mar, 2022 | 16:12h

Diagnosing tuberculosis – Cochrane Library

Adoçantes artificiais e risco de câncer: resultados de estudo de coorte de base populacional do NutriNet-Santé.

25 Mar, 2022 | 16:11h

Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study – PLOS Medicine

Comentários:

Sweeteners may be linked to increased cancer risk – new research – The Conversation

Expert reaction to observational study of sweeteners and cancer risk – Science Media Centre

3 cirurgias ortopédicas que podem trazer mais prejuízo do que benefício aos pacientes (e seus bolsos).

25 Mar, 2022 | 16:06h

3 orthopaedic surgeries that might be doing patients (and their pockets) more harm than good – The Conversation

[Preprint] Estudo randomizado | Suplementação de vitamina D não evita Covid-19 ou outras infecções respiratórias agudas.

25 Mar, 2022 | 16:01h

Vitamin D Supplements for Prevention of Covid-19 or other Acute Respiratory Infections: a Phase 3 Randomized Controlled Trial (CORONAVIT) – medRxiv

Conteúdos relacionados:

M-A: Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19.

In a Mendelian randomization study, researchers found no genetic evidence to support an association between Vitamin D levels and COVID-19 susceptibility, severity, or hospitalization.

Living systematic review: The evidence is insufficient to determine the benefits and harms of vitamin D supplementation as a treatment of COVID‐19.

RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19

Comentário no Twitter (fio – clique para saber mais)

CORONAVIT trial (vitamin D supplements for Covid prevention) results are negative, but the implications are narrow and must not be misinterpreted.https://t.co/mnmDeOJFak
This was a well done trial in many ways. Here's what is reasonable to conclude from it & what isn't:

— Karl Pfleger, PhD (@KarlPfleger) March 24, 2022

Coorte retrospectiva | Um estudo de base populacional feito na Suécia e na Noruega não encontrou um risco aumentado de complicações gestacionais após vacinação contra COVID-19.

Como erramos em nossas opiniões sobre imunidade de rebanho.

Prevalência de rotulagem da alergia à penicilina variou de 0,9% a 10,2% entre práticas em uma ampla coorte pediátrica, levantando questões sobre a validade desses rótulos e o uso desnecessário de antibióticos de segunda linha que pode se seguir.