Covid-19

Análise provisória | Sabizabulina oral para adultos de alto risco internados com Covid-19.

11 Jul, 2022 | 13:59h

Oral Sabizabulin for High-Risk, Hospitalized Adults with Covid-19: Interim Analysis – NEJM Evidence

 

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Estudo randomizado | Plasma convalescente neutralizante de COVID-19 não traz benefícios a adultos internados com a doença.

11 Jul, 2022 | 13:58h

Neutralizing COVID-19 Convalescent Plasma in Adults Hospitalized with COVID-19: A Blinded Randomized Placebo-Controlled Trial – CHEST

Comentário: Study shows convalescent plasma doesn’t benefit severely ill patients hospitalized with COVID-19 – Vanderbilt University Medical Center

 

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Estudo de caso controle e teste negativo | Efetividade da 4ª dose de vacina de mRNA contra Covid-19 causada pela variante Ômicron entre residentes de instituições de longa permanência em Ontário, Canadá.

8 Jul, 2022 | 11:30h

Effectiveness of a fourth dose of covid-19 mRNA vaccine against the omicron variant among long term care residents in Ontario, Canada: test negative design study – The BMJ

 

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Estudo de coorte retrospectiva | Viés racial e reprodutibilidade da oximetria de pulso entre pacientes internados clínicos e cirúrgicos.

8 Jul, 2022 | 11:24h

Racial bias and reproducibility in pulse oximetry among medical and surgical inpatients in general care in the Veterans Health Administration 2013-19: multicenter, retrospective cohort study – The BMJ

Comunicado de imprensa: Pulse oximeters missed low oxygen levels in more Black veterans than white veterans – University of Michigan

Conteúdos relacionados:

Racial and Ethnic Discrepancy in Pulse Oximetry and Delayed Identification of Treatment Eligibility Among Patients With COVID-19 – JAMA Internal Medicine

Racial Bias in Pulse Oximetry Measurement – New England Journal of Medicine

Pulse Oximetry for Monitoring Patients with Covid-19 at Home — A Pragmatic, Randomized Trial – New England Journal of Medicine

Effectiveness and safety of pulse oximetry in remote patient monitoring of patients with COVID-19: a systematic review – The Lancet Digital Health

FDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias – STAT

Pulse Oximeter Accuracy and Limitations: FDA Safety Communication – U.S. Food & Drug Administration

 

Comentário no Twitter

New research found that for individuals in general (medical and surgical) care in hospital, occult hypoxemia was more common for black patients than for white patients https://t.co/DrNlaIE7ho

— The BMJ (@bmj_latest) July 6, 2022

 

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Estudo randomizado | Alta dose de dexametasona e estratégias de suporte de oxigênio em pacientes na UTI com insuficiência respiratória hipoxêmica aguda grave por COVID-19.

7 Jul, 2022 | 12:23h

High-Dose Dexamethasone and Oxygen Support Strategies in Intensive Care Unit Patients With Severe COVID-19 Acute Hypoxemic Respiratory Failure: The COVIDICUS Randomized Clinical Trial – JAMA Internal Medicine

 

Comentário no Twitter

In this RCT, high-dose dexamethasone did not significantly improve the 60-day survival. The oxygenation strategy in initially non-intubated patients did not significantly modify the 28-day risk of invasive mechanical ventilation requirement. https://t.co/ZNajW2KBKR

— JAMA Internal Medicine (@JAMAInternalMed) July 5, 2022

 

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Revisão | O momento de hesitação da vacina.

7 Jul, 2022 | 12:21h

The Vaccine-Hesitant Moment – New England Journal of Medicine

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Riscos específicos relacionados a idade e sexo para miocardite e pericardite após vacinação contra Covid-19 com vacinas de RNA mensageiro.

7 Jul, 2022 | 12:20h

Age and sex-specific risks of myocarditis and pericarditis following Covid-19 messenger RNA vaccines – Nature Communications

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Revisão | Preenchendo as lacunas de conhecimento no diagnóstico e no tratamento de sequelas neuropsiquiátricas da COVID-19.

6 Jul, 2022 | 11:14h

Bridging Knowledge Gaps in the Diagnosis and Management of Neuropsychiatric Sequelae of COVID-19 – JAMA Psychiatry

 

Comentário no Twitter

Neuropsychiatric post-acute sequelae of #COVID19 appear common but heterogeneous. Studies such as the NIH RECOVER initiative are needed to clarify neuropsychiatric PASC epidemiology, pathophysiology, mechanisms of injury and targets for intervention. https://t.co/AjwoLrZXc7

— JAMA Psychiatry (@JAMAPsych) July 1, 2022

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Más notícias para a Paxlovid? Coronavírus pode encontrar múltiplas vias para escapar do medicamento para COVID-19.

5 Jul, 2022 | 12:01h

Bad news for Paxlovid? Coronavirus can find multiple ways to evade COVID-19 drug – Science

Ver também: SARS-CoV-2 can evade Paxlovid by multiple mechanisms – News Medical

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Opinião | FDA: não faça nenhum movimento para mudar a composição da vacina contra Covid-19.

5 Jul, 2022 | 11:59h

FDA: Don’t rush a move to change the Covid-19 vaccine composition – STAT

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