Covid-19

Estudo RECOVERY | Por questões de segurança, o recrutamento de pacientes com Covid-19 apresentando hipóxia sem oxigênio ou recebendo oxigênio simples para doses mais altas de corticosteroides foi encerrado.

18 Mai, 2022 | 17:00h

Recruitment to higher dose corticosteroids closed for patients with hypoxia on no oxygen or receiving simple oxygen – University of Oxford

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Estudo de coorte | Trombose venosa ou arterial e mortes em casos de COVID-19.

18 Mai, 2022 | 16:58h

Venous or arterial thrombosis and deaths among COVID-19 cases: a European network cohort study – The Lancet Infectious Diseases

Comentário convidado: Risk of arterial and venous thromboses after COVID-19 – The Lancet Infectious Diseases

Comunicado de imprensa: COVID-19’s high blood clot risk – University of Oxford

 

Comentário no Twitter

Clots with Covid: Multi-national report of over 900,000 people indicates propensity of risk for arterial and venous thrombi is in men, with increasing age, and association with fatalities (4-fold in non-hospitalized) https://t.co/muGnDld4Um pic.twitter.com/6bLiHPLInm

— Eric Topol (@EricTopol) May 13, 2022

Sob licença de Creative Commons Attribution (CC BY 4.0)

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Estudo de coorte | Risco de morte e reinternação não planejada após alta hospitalar de internação por COVID-19.

18 Mai, 2022 | 16:56h

The risk of death or unplanned readmission after discharge from a COVID-19 hospitalization in Alberta and Ontario – Canadian Medical Association Journal

Comentário: Study: Readmission rate for COVID-19 is 11% – CIDRAP

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Estudo randomizado | Efeito da posição prona na entubação endotraqueal de pacientes com COVID-19 e insuficiência respiratória aguda.

17 Mai, 2022 | 12:13h

Effect of Awake Prone Positioning on Endotracheal Intubation in Patients With COVID-19 and Acute Respiratory Failure: A Randomized Clinical Trial – JAMA

Conteúdos relacionados:

Assessment of Awake Prone Positioning in Hospitalized Adults With COVID-19: A Nonrandomized Controlled Trial – JAMA Internal Medicine

Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxaemic respiratory failure: a systematic review and meta-analysis – The Lancet Respiratory Medicine

Prone positioning of patients with moderate hypoxaemia due to covid-19: multicentre pragmatic randomised trial (COVID-PRONE) – The BMJ

RCT: Prone positioning of patients with moderate hypoxia due to COVID-19 – medRxiv

Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial – The Lancet Respiratory Medicine

Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19: the PROFLO multicenter randomized clinical trial – Critical Care

Prone Positioning of Nonintubated Patients With Coronavirus Disease 2019—A Systematic Review and Meta-Analysis – Critical Care Medicine

 

Comentário no Twitter

In this trial, in patients with acute hypoxemic respiratory failure from #COVID19, prone positioning, compared with usual care without prone positioning, did not significantly reduce endotracheal intubation at 30 days. https://t.co/1RyYRtcrYj

— JAMA (@JAMA_current) May 15, 2022

 

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Estudo de caso-controle e teste negativo | Associação entre vacinação prévia com BNT162b2 contra COVID-19 e infecção sintomática por SARS-CoV-2 em crianças e adolescentes durante a predominância da variante Ômicron.

17 Mai, 2022 | 12:04h

Association of Prior BNT162b2 COVID-19 Vaccination With Symptomatic SARS-CoV-2 Infection in Children and Adolescents During Omicron Predominance – JAMA

Estudo relacionado: Risk of Infection and Hospitalization Among Vaccinated and Unvaccinated Children and Adolescents in New York After the Emergence of the Omicron Variant – JAMA

Editorial: Protecting Children Against Omicron – JAMA

 

Comentário no Twitter (fio – clique para saber mais)

This new JAMA study is worth discussing. It found that, this winter, vax effectiveness in 12-15 yos dropped to 0% after 3-5 months & vaccinated were MORE likely to test+ at month 7. May be confounded (see🧵)
But I don't see this as good reason for boostershttps://t.co/zpkIDdZhnn pic.twitter.com/bxAIDmiR8s

— Tracy Høeg, MD, PhD (@TracyBethHoeg) May 14, 2022

 

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Novas versões da variante Ômicron são mestres da evasão imunológica.

16 Mai, 2022 | 16:47h

New versions of Omicron are masters of immune evasion – Science

 

Comentário no Twitter

"Based on its immunological profile, it [Omicron & its subvariants] should be called SARS-3"https://t.co/zxV3T2SKIB@gretchenvogel @NewsfromScience
w/ @K_G_Andersen @Tuliodna @linfa_wang pic.twitter.com/ToKDqNGH74

— Eric Topol (@EricTopol) May 12, 2022

 

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Revisão | Manifestações da COVID-19 e outros coronavírus em exames de imagem torácica.

16 Mai, 2022 | 16:46h

Review of Thoracic Imaging Manifestations of COVID-19 and Other Pathologic Coronaviruses – Radiology Clinics of North America

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Diretrizes atualizadas da IDSA sobre tratamento e manejo de pacientes com COVID-19.

16 Mai, 2022 | 16:44h

IDSA Guidelines on the Treatment and Management of Patients with COVID-19 – Infectious Diseases Society of America

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[Preprint] Covid longa: revisão sistemática e metanálise de 120.970 pacientes.

16 Mai, 2022 | 16:41h

Long Covid: A Systematic Review and Meta-Analysis of 120,970 Patients – Preprints with The Lancet

 

Comentário no Twitter

A systematic #LongCovid review of nearly 200 studies and over 120,000 participants, reinforces the high frequency of symptoms > 6 months, not linked to severity of acute illness, and potential for marked disabilityhttps://t.co/9NYQT1P79G pic.twitter.com/WFzBqghbGI

— Eric Topol (@EricTopol) May 6, 2022

 

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Características clínicas e fatores de risco de COVID-19 grave ou fatal entre pessoas internadas que vivem com HIV: análise de dados da WHO Global Clinical Platform of COVID-19.

16 Mai, 2022 | 16:39h

Clinical features of, and risk factors for, severe or fatal COVID-19 among people living with HIV admitted to hospital: analysis of data from the WHO Global Clinical Platform of COVID-19 – The Lancet HIV

Comentário convidado: A collision of pandemics: HIV and COVID-19 – The Lancet HIV

 

Comentários no Twitter

New: Clinical features of, and risk factors for, severe or fatal COVID-19 among people living with HIV admitted to hospital: analysis of data from the WHO Global Clinical Platform of COVID-19 by Silvia Bertagnolio and colleagues https://t.co/hAyuWi7fMN #openaccess pic.twitter.com/VmjeYMLPHu

— The Lancet HIV (@TheLancetHIV) May 11, 2022

Clinical features of, and risk factors for, severe or fatal COVID-19 among PLWH admitted to hospital…. https://t.co/KKVKwroy4Z Compared with individuals without HIV, PLWH (96% living in Africa) had 15% ⬆️ odds of severe COVID-19 and were 38% more likely to die in hospital.

— Carlos del Rio (@CarlosdelRio7) May 12, 2022

 

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