Clínica Médica

Evidências e fontes da Cochrane Library | Úlceras de pressão.

18 Jul, 2022 | 13:05h

Pressure ulcers (pressure injuries): evidence and resources – Evidently Cochrane

 

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Estudo randomizado | Teste farmacogenômico para interações medicamento-genes fornece pouco benefício à remissão de sintomas no transtorno depressivo maior.

18 Jul, 2022 | 13:04h

Effect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial – JAMA (gratuito por tempo limitado)

Editorial: Pharmacogenomic Testing for Next-Step Antidepressant Selection: Still a Work in Progress – JAMA (gratuito por tempo limitado)

Comentário: Does Pharmacogenomic Testing Improve Outcomes in Major Depressive Disorder? — The evidence is unclear – MedPage Today (necessário cadastro gratuito)

 

Comentário no Twitter

In this randomized clinical trial, pharmacogenomic testing for drug-gene interactions in major depressive disorder reduced prescription of medications with predicted drug-gene interactions but had small and nonpersistent effects on symptom remission. https://t.co/Z2OIK3h1Bo pic.twitter.com/8eKSipfBFN

— JAMA (@JAMA_current) July 12, 2022

 

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Diretriz de consenso | Indicações clínicas e triagem para ecocardiografia transtorácica em adultos.

18 Jul, 2022 | 12:51h

Clinical indications and triaging for adult transthoracic echocardiography: a consensus statement by the British Society of Echocardiography in collaboration with British Heart Valve Society

 

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Revisão sistemática | Terapias anti-IL-5 para asma.

18 Jul, 2022 | 12:46h

Anti‐IL‐5 therapies for asthma – Cochrane Library

Resumo: Mepolizumab, reslizumab or benralizumab for people already taking inhaled steroids and long-acting beta 2-agonists for their asthma – Cochrane Library

 

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Análise de conjunto de dados de registro nacional | Prevalência de doença cardiovascular em pacientes com malignidades potencialmente curáveis.

18 Jul, 2022 | 12:43h

Prevalence of Cardiovascular Disease in Patients With Potentially Curable Malignancies: A National Registry Dataset Analysis – JACC: CardioOncology

Editorial: How Common Is Pre-Existing Cardiovascular Disease in Cancer Patients: What Do We Know? Does It Matter? – JACC: CardioOncology

 

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M-A | Risco de desenvolvimento de câncer de vesícula biliar em pacientes com pólipos vesiculares detectados em ultrassonografia transabdominal.

18 Jul, 2022 | 12:30h

Risk of developing gallbladder cancer in patients with gallbladder polyps detected on Trans-Abdominal ultrasound: a systematic review and Meta-Analysis – British Journal of Radiology (link para o resumo – $ para o texto completo)

Conteúdos relacionados:

Critical Analysis of the Updated Guidelines for Management of Gallbladder Polyps – Annals of Surgical Oncology (se o acesso a este link for pago, tente este)

Guideline: Management and follow-up of gallbladder polyps – “If the patient has no risk factors for malignancy, and a gallbladder polypoid lesion of 5 mm or less, follow-up is not required”.

 

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Estudo randomizado | Trombectomia endovascular isoladamente NÃO é não inferior à ponte trombolítica padrão associada a trombectomia endovascular dentro de 4,5 horas do início do AVC.

14 Jul, 2022 | 12:05h

Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial – The Lancet (link para o resumo – $ para o texto completo)

Estudo relacionado: Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial – The Lancet (link para o resumo – $ para o texto completo)

 

Comentário no Twitter

Two new RCTs show we shouldn't skip bridging intravenous thrombolysis in eligible thrombectomy patients: DIRECT-SAFE (n=293) & SWIFT DIRECT (n=408) @TheLancet @SNISinfo@cvsection https://t.co/Tks14TlaVFhttps://t.co/WaTPn34diy pic.twitter.com/Gcddws8oDf

— Babak Jahromi MD PhD FRCSC (@babaksjahromi) July 9, 2022

 

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Estudo randomizado | Trombectomia isolada NÃO é não inferior a alteplase intravenosa com trombectomia em pacientes com AVC.

14 Jul, 2022 | 12:04h

Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial – The Lancet (link para o resumo – $ para o texto completo)

Estudo relacionado: Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial – The Lancet (link para o resumo – $ para o texto completo)

 

Comentário no Twitter

Two new RCTs show we shouldn't skip bridging intravenous thrombolysis in eligible thrombectomy patients: DIRECT-SAFE (n=293) & SWIFT DIRECT (n=408) @TheLancet @SNISinfo@cvsection https://t.co/Tks14TlaVFhttps://t.co/WaTPn34diy pic.twitter.com/Gcddws8oDf

— Babak Jahromi MD PhD FRCSC (@babaksjahromi) July 9, 2022

 

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Estudo randomizado | Inibição de miosina em pacientes com cardiomiopatia hipertrófica obstrutiva encaminhados para terapia de redução de septo.

14 Jul, 2022 | 12:02h

Myosin Inhibition in Patients With Obstructive Hypertrophic Cardiomyopathy Referred for Septal Reduction Therapy – Journal of the American College of Cardiology

Conteúdo relacionado: #ACC22 [Not published yet] – RCT: Mavacamten reduces the need for surgical intervention in patients with obstructive hypertrophic cardiomyopathy.

 

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Tratamento da febre em adultos: revisão sistemática com metanálise e análises de estudos sequenciais.

14 Jul, 2022 | 12:01h

Fever therapy in febrile adults: systematic review with meta-analyses and trial sequential analyses – The BMJ

 

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