Clínica Médica

Estudo randomizado | Em pacientes não críticos internados com COVID-19, o uso de inibidor de P2Y12 (ticagrelor em 63% dos pacientes e clopidogrel em 37%) adicionado à dose terapêutica de heparina não melhorou a sobrevida livre de suporte de órgãos em comparação à heparina terapêutica isolada.

20 Jan, 2022 | 22:21h

Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non–Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial – JAMA

Editorial: Antiplatelet Therapy in Patients With COVID-19—More Is Less? – JAMA

Comentário: Adding a P2Y12 Inhibitor Does Not Improve Outcomes in COVID-19 – HealthDay

Checagem de fatos: sobre a teoria de que o SARS-CoV-2 está se tornando mais leve.

20 Jan, 2022 | 22:12h

Fact check: The theory that SARS-CoV-2 is becoming milder – NPR

Estudo randomizado | Em adultos com doença crítica, o uso de solução balanceada de multieletrólitos não reduziu o risco de morte ou lesão renal aguda em comparação à solução salina padrão.

20 Jan, 2022 | 22:05h

Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults – New England Journal of Medicine (link para o resumo – $ para o texto completo)

Comentário: Australian study set to guide the treatment of critically ill patients worldwide – George Institute for Global Health

Conteúdos relacionados:

BaSICS RCT: Among critically ill patients requiring fluid therapy, treatment with a balanced solution did not lead to reduced mortality compared to a 0.9% saline solution.

BaSICS RCT: Among critically ill patients requiring fluid therapy, there was no difference in mortality with slower (333 mL/h) vs. faster (999 mL/h) intravenous fluid bolus rates.

Cochrane Review: Buffered Solutions Do Not Improve Mortality in Critically Ill Adults and Children Compared to 0,9% Saline

Comentário no Twitter

Trial of critically ill patients compared balanced multielectrolyte solution (BMES) with saline as fluid therapy in the ICU. There was no evidence that the risk of death or acute kidney injury was lower with the use of BMES than with saline. https://t.co/bmlg4BYaw8 pic.twitter.com/OlKGOM0Dmm

— NEJM (@NEJM) January 18, 2022