Acesso livre
Acesso livre

Clínica Médica

Estudo randomizado | Estudo preliminar sugere que a neostigmina pode melhorar a hipertensão intra-abdominal e a defecação em pacientes com pancreatite aguda.

8 Mar, 2022 | 16:43h

Randomized controlled trial: neostigmine for intra-abdominal hypertension in acute pancreatitis – Critical Care

Revisão sistemática | Distribuição dos subtipos de delirium motor na UTI.

8 Mar, 2022 | 16:42h

Distribution of delirium motor subtypes in the intensive care unit: a systematic scoping review – Critical Care

M-A | Cirurgia bariátrica e doença cardiovascular.

8 Mar, 2022 | 16:39h

Bariatric surgery and cardiovascular disease: a systematic review and meta-analysis – European Heart Journal

[Preprint] Estudo RECOVERY mostra que baricitinibe reduz mortes em pacientes internados com COVID-19.

8 Mar, 2022 | 16:22h

Comunicado de imprensa: RECOVERY trial shows Baricitinib reduces deaths in patients hospitalised with COVID-19 – University of Oxford

Estudo original: Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis – medRxiv

Comentários:

Arthritis drug reduces mortality in severe COVID-19, huge clinical trial finds – Science

Covid-19: Anti-inflammatory treatment baricitinib reduces deaths in patients admitted to hospital, finds trial – The BMJ

Another life-saving Covid drug identified – BBC

Conteúdos relacionados:

WHO recommends two new drugs (Baricitinib and Sotrovimab) to treat COVID-19.

RCT: Baricitinib reduced mortality in hospitalized adults with COVID-19.

Randomized trial: Baricitinib plus remdesivir reduce recovery time in patients with COVID-19

 

Comentário do autor no Twitter (fio – clique para saber mais)

 

M-A | Eficácia das vacinas contra Covid-19 em pacientes imunocomprometidos.

8 Mar, 2022 | 16:16h

Efficacy of covid-19 vaccines in immunocompromised patients: systematic review and meta-analysis – The BMJ

Comunicado de imprensa: Study suggests additional covid-19 vaccine doses for immunocompromised patients – BMJ Newsroom

Conteúdos relacionados: Response to additional COVID-19 vaccine doses in people who are immunocompromised: a rapid review.

 

Comentário no Twitter

 

Diretriz atualizada da OMS recomenda condicionalmente o molnupiravir para pacientes com Covid-19 não grave sob alto risco de internação.

8 Mar, 2022 | 16:14h

Comunicado de imprensa BMJ: WHO recommends antiviral drug for patients with non-severe covid-19 at highest risk of hospital admission – BMJ

Comunicado de imprensa OMS: WHO updates its treatment guidelines to include molnupiravir

Ver diretriz atualizada: A living WHO guideline on drugs for covid-19 – BMJ

Conteúdos relacionados:

Editorial (recém-publicado): Molnupiravir’s authorisation was premature – The BMJ

RCT: Molnupiravir reduced the risk of hospitalization or death in at-risk (i.e., obesity, over 60 years, etc.) unvaccinated adults with Covid-19.

Merck’s COVID pill loses its luster: what that means for the pandemic – “Molnupiravir was initially heralded by public-health officials as a game-changer for COVID-19, but full clinical-trial data showed lower-than-expected efficacy”.

FDA panel narrowly recommends authorization of first antiviral pill to treat COVID.

[Press release – not published yet] Merck’s new Covid-19 pill Molnupiravir updated data shows reduced efficacy (30%) for preventing hospitalization and death compared to initial results (50%). Absolute risk reduction of hospitalization and death fell from 7% to 3%.

8 lingering questions about the new Covid pills from Merck and Pfizer.

COVID antiviral pills: what scientists still want to know – “Drugs like Molnupiravir and Paxlovid could change the course of the pandemic if clinical trial results hold up in the real world”.

[Press release – not published yet] RCT: Pfizer’s novel Covid-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR study.

A prominent virologist warns new COVID-19 pill could unleash dangerous mutants. Others see little cause for alarm.

The U.K. approves Merck’s COVID-19 antiviral pill, calling it a world first.

Merck to allow other nations to produce new COVID-19 antiviral.

Video: Merck’s Covid pill could transform treatment. Here’s how it works.

How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.

What we know — and don’t know — about Merck’s new Covid-19 pill.

[Press release – not published yet] Merck announces oral antiviral Molnupiravir reduced the risk of hospitalization or death by approximately 50 Percent compared to placebo for patients with mild or moderate COVID-19.

Merck’s Covid-19 pill is great news but may not be a game-changer.

Video | A Pill For COVID? A Doctor Explains Molnupiravir.

Ponto de vista | Compreensão e comunicação da incerteza na obtenção da excelência em diagnósticos.

8 Mar, 2022 | 16:11h

Understanding and Communicating Uncertainty in Achieving Diagnostic Excellence – JAMA (gratuito por tempo limitado)

Revisão sistemática | Artroscopia fornece pouco ou nenhum benefício clinicamente importante para pacientes com doença degenerativa no joelho.

8 Mar, 2022 | 16:06h

Arthroscopic surgery for degenerative knee disease (osteoarthritis including degenerative meniscal tears) – Cochrane Library

Resumo: Arthroscopic surgery for degenerative knee disease – Cochrane Library

Conteúdos relacionados:

Guideline: Arthroscopic Meniscal Surgery

Arthroscopic surgery for degenerative knee arthritis and meniscal tears: a clinical practice guideline

Randomized Trial: Early Surgery vs Physical Therapy on Knee Function Among Patients With Nonobstructive Meniscal Tears

Study: Adverse Outcomes After Arthroscopic Partial Meniscectomy

Estudo diagnóstico randomizado | Medidas domiciliares de pressão arterial se correlacionam melhor com medidas de monitoramento ambulatorial de 24 horas em comparação às medidas tomadas em clínicas e postos.

8 Mar, 2022 | 16:03h

Clinic, Home, and Kiosk Blood Pressure Measurements for Diagnosing Hypertension: a Randomized Diagnostic Study – Journal of General Internal Medicine

Comentário: Home blood pressure monitoring may provide the basis for accurate diagnoses of hypertension – Kaiser Permanente

Diretriz para acompanhamento ambulatorial do controle glicêmico em pessoas com câncer.

8 Mar, 2022 | 15:59h

A guideline for the outpatient management of glycaemic control in people with cancer – Diabetic Medicine

Mantenha-se atualizado em sua especialidade

 

Escolha quantas especialidades quiser.