Clínica Médica

Estudo randomizado | Em pacientes com enxaqueca crônica e uso excessivo de medicações sintomáticas, a terapia de prevenção de enxaqueca sem trocar ou limitar a frequência da medicação usada em excesso foi não inferior à substituição por um sintomático diferente com a limitação máxima de 2 dias de tratamento/semana.

25 Mar, 2022 | 15:41h

Patient-Centered Treatment of Chronic Migraine With Medication Overuse: A Prospective, Randomized, Pragmatic Clinical Trial – Neurology (link para o resumo – $ para o texto completo)

---

M-A | Mortalidade da bacteriemia por Staphylococcus aureus.

25 Mar, 2022 | 15:31h

Staphylococcus aureus bacteremia mortality: A systematic review and meta-analysis – Clinical Microbiology and Infection

---

M-A | Rastreamento da tuberculose entre pacientes HIV-positivos internados.

25 Mar, 2022 | 15:30h

Tuberculosis screening among HIV-positive inpatients: a systematic review and individual participant data meta-analysis – The Lancet HIV

 

Comentário no Twitter

Tuberculosis screening among HIV-positive inpatients: a systematic review and individual participant data meta-analysis https://t.co/DqTUr2JxHy In setting where TB prevalence is > 10%, WHO now strongly recommends molecular rapid diagnostic testing in all medical inpatient PWH.

— Carlos del Rio (@CarlosdelRio7) March 24, 2022

 

---

Estudo randomizado | Tratamento com dose única de anfotericina B lipossomal para meningite por criptococo.

25 Mar, 2022 | 15:01h

Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis – New England Journal of Medicine (link para o resumo – $ para o texto completo)

 

Comentário no Twitter

Cryptococcal meningitis is a major complication of HIV infection. Single-dose liposomal amphotericin B combined with flucytosine and fluconazole was noninferior to the WHO-recommended treatment and was associated with fewer adverse events. https://t.co/cg9DqSDhyN pic.twitter.com/SrKx4tDaph

— NEJM (@NEJM) March 23, 2022

 

---

Estudo observacional sugere que antieméticos antidopaminérgicos (domperidona, metopimazina e metoclopramida) estão associados com risco aumentado de AVC.

25 Mar, 2022 | 14:59h

Risk of first ischaemic stroke and use of antidopaminergic antiemetics: nationwide case-time-control study – The BMJ

Comunicado de imprensa: Widely used nausea drugs linked to heightened risk of stroke – BMJ

---

Estudo randomizado | Posição prona em pacientes não intubados não melhorou os desfechos em pacientes com hipoxemia moderada relacionada à Covid-19.

25 Mar, 2022 | 14:58h

Prone positioning of patients with moderate hypoxaemia due to covid-19: multicentre pragmatic randomised trial (COVID-PRONE) – The BMJ

Editorial: Awake prone positioning for patients with covid-19

Comunicado de imprensa: Lying prone long enough to improve outcomes is difficult for many covid-19 patients – BMJ

---

Revisão sistemática | Efetividade e segurança da oximetria de pulso no monitoramento remoto de pacientes com COVID-19.

25 Mar, 2022 | 14:54h

Effectiveness and safety of pulse oximetry in remote patient monitoring of patients with COVID-19: a systematic review – The Lancet Digital Health

Comentários:

Home blood oxygen monitoring can help COVID patients spot early warning signs – Imperial College London

Simple home oxygen monitors signal when to seek COVID care – CIDRAP

---

Estudo randomizado | Multivitamínicos não são benéficos para a prevenção do câncer.

25 Mar, 2022 | 14:50h

Multivitamins in the prevention of cancer and cardiovascular disease: The COSMOS randomized clinical trial – American Journal of Clinical Nutrition

Comentário: Daily Multivitamin Does Not Cut Cancer Incidence in Older Adults – HealthDay

Conteúdo relacionado: USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

---

Diretriz | Avaliação e tratamento médico do paciente com cálculo renal.

25 Mar, 2022 | 14:47h

Update – 2022 Canadian Urological Association guideline: Evaluation and medical management of the kidney stone patient – Canadian Urological Association Journal

Diretrizes relacionadas:

Canadian Urological Association guideline: Management of ureteral calculi – Abridged version – Canadian Urological Association Journal

Renal and ureteric stones: assessment and management – National Institute for Health and Care Excellence

Dietary and Pharmacologic Management to Prevent Recurrent Nephrolithiasis in Adults: A Clinical Practice Guideline From the American College of Physicians

Metabolic diagnosis and medical prevention of calcium nephrolithiasis and its systemic manifestations: a consensus statement – Journal of Nephrology

The Urological Association of Asia clinical guideline for urinary stone disease – International Journal of Urology

---

Delirium está associado a aumento de mortes hospitalares.

25 Mar, 2022 | 14:34h

Comunicado de imprensa: Delirium linked to increase in hospital deaths – University of Edinburgh

Estudo original: Positive scores on the 4AT delirium assessment tool at hospital admission are linked to mortality, length of stay and home time: two-centre study of 82,770 emergency admissions – Age and Ageing

 

Comentário no Twitter

Positive scores on the 4AT delirium assessment tool at hospital admission are linked to mortality, length of stay and home time: two-centre study of 82,770 emergency admissions.
Thank you @emmavardy2 @A_MacLullich @atula_tweets Michael Cheng, Temi Ibitoye https://t.co/bBjBQ3xpTd

— Age_and_Ageing (@Age_and_Ageing) March 16, 2022

 

---