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Clínica Médica

Perspectiva | As evidências sobre a 4ª dose das vacinas contra Covid & a questão complicada dos limites de idade.

6 Abr, 2022 | 12:53h

The Evidence On 4th Doses of Covid Vaccines & the Thorny Question of Age Thresholds – Absolutely Maybe Blog, by Hilda Bastian

Conteúdos relacionados:

U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.

[Preprint] Retrospective cohort study: second booster vaccine and Covid-19 mortality in adults 60 to 100 years old.

Among health care workers, a fourth dose vaccine effectiveness against any SARS-CoV-2 Omicron variant infection was 30% for the Pfizer–BioNTech and 11% for the Moderna.

[Preprint] Fourth dose of COVID vaccine offers only slight boost against Omicron infection.

Covid-19: Fourth vaccine doses—who needs them and why?

[Not published yet] Study in Israel finds fourth COVID booster has limited efficacy.

 

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Estudo de coorte | Níveis séricos elevados de sódio na meia-idade (pode haver correlação com baixa ingestão hídrica) estão associados a risco aumentado de hipertrofia ventricular e insuficiência cardíaca após 25 anos de seguimento.

6 Abr, 2022 | 12:51h

Middle age serum sodium levels in the upper part of normal range and risk of heart failure – European Heart journal (link para o resumo – $ para o texto completo)

Comunicado de imprensa: Good hydration may reduce long-term risks for heart failure – Serum sodium levels may help identify adults with a greater chance of experiencing heart disease. – National Institutes of Health

Opinião | Cannabis medicinal para dor crônica: o triângulo das Bermudas dos estudos de baixa qualidade, incontáveis metanálises e recomendações conflitantes.

6 Abr, 2022 | 12:49h

Medicinal Cannabis for Chronic Pain: The Bermuda Triangle of Low Quality Studies, Countless Meta-analyses and Conflicting Recommendations – European Journal of Pain

Conteúdos relacionados:

RCT: Effect of medical marijuana card ownership on pain, insomnia, and affective disorder symptoms in adults.

Cohort Study: Long-term cannabis use is associated with cognitive deficits and smaller hippocampal volume in midlife.

AHA Scientific Statement | How does cannabis use affect brain health? Caution advised, more research needed.

M-A: Birth outcomes of neonates exposed to marijuana in utero.

Cannabis-related allergies: an international overview and consensus recommendations.

Review: Cannabis-based medicines and medical cannabis for chronic neuropathic pain.

Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions.

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain.

The International Cannabis Toolkit (iCannToolkit): a multidisciplinary expert consensus on minimum standards for measuring cannabis use.

Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.

Guideline: Medical cannabis or cannabinoids for chronic pain.

Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.”

NICE Guideline: Cannabis-Based Medicinal Products

Consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Short Review: Drug Interactions with Cannabinoids

Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain

Review: Considerations for cannabinoids in perioperative care by anesthesiologists.

Review: Cannabis-based Medicines and the Perioperative Physician

Study: Cannabis Use Disorder May Increase the Risk of Cardiovascular Events in Major Elective Surgeries

Perspective: If You Smoke Pot, Your Anesthesiologist Needs To Know

Perioperative Care of Cannabis Users: A Comprehensive Review of Pharmacological and Anesthetic Considerations

Estudo de coorte | Mudança nas taxas de mortalidade por doença cardíaca e AVC antes e durante a pandemia de Covid-19.

6 Abr, 2022 | 12:46h

Age-Adjusted Mortality Rates and Age and Risk–Associated Contributions to Change in Heart Disease and Stroke Mortality, 2011-2019 and 2019-2020 – JAMA Network Open

Comentários:

Several-Fold Increase in Stroke and Heart Disease Deaths During COVID-19 Pandemic – NeurologyToday

2019 to 2020 Saw Risk-Linked Deaths From Heart Disease, Stroke Up – HealthDay

 

Comentário do autor no Twitter (fio – clique pra saber mais). Artigo e imagens sob CC-BY License

 

Guia prático EHRA | Como usar dispositivos digitais para detectar e tratar arritmias.

6 Abr, 2022 | 12:44h

How to use digital devices to detect and manage arrhythmias: an EHRA practical guide – EP Europace

Comunicado de imprensa: Advice on how to use digital devices to detect and manage arrhythmias published today – European Society of Cardiology

Revisão | Terapia antiplaquetária após intervenção coronariana percutânea.

6 Abr, 2022 | 12:39h

Antiplatelet therapy after percutaneous coronary intervention – EuroIntervention

 

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Estudo randomizado | Eficácia e segurança do daprodustate (medicamento oral) para tratar anemia na doença renal crônica em pacientes dialíticos.

6 Abr, 2022 | 12:35h

Efficacy and Safety of Daprodustat for Treatment of Anemia of Chronic Kidney Disease in Incident Dialysis Patients: A Randomized Clinical Trial – JAMA Internal Medicine

Conteúdos relacionados:

RCT: In patients with chronic kidney diseases and anemia undergoing dialysis, Daprodustat (oral drug) was noninferior to darbepoetin alfa to increase hemoglobin levels and regarding cardiovascular outcomes.

RCT: In patients with chronic kidney diseases and anemia not undergoing dialysis, Daprodustat (oral drug) was noninferior to darbepoetin alfa in increasing hemoglobin levels and regarding cardiovascular outcomes.

 

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M-A | Eficácia de intervenções para reduzir o tratamento de longo prazo com opioides para dor crônica não oncológica.

6 Abr, 2022 | 12:32h

Efficacy of interventions to reduce long term opioid treatment for chronic non-cancer pain: systematic review and meta-analysis – The BMJ

Podcast | Dicas sobre pancreatite aguda.

6 Abr, 2022 | 12:31h

#327 Acute Pancreatitis – The Curbsiders

Revisão | A perspectiva do intensivista sobre choque, gerenciamento de volume e monitoramento hemodinâmico.

6 Abr, 2022 | 12:28h

The Intensivist’s Perspective of Shock, Volume Management, and Hemodynamic Monitoring – Clinical Journal of the American Society of Nephrology

 

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