Alergia e Imunologia

Estudo mostra atividade reduzida de anticorpos neutralizantes, induzida pela vacina da Pfizer–BioNTech, contra as variantes de preocupação do SARS-CoV-2 B.1.617.2 (Delta) e B.1.351 (Beta).

7 Jun, 2021 | 10:31h

Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2  and B.1.351 (Beta) by BNT162b2 vaccination – The Lancet

Comentário: Pfizer-BioNTech vaccine recipients have lower antibody levels targeting the Delta variant – The Francis Crick Institute

 

Comentário no Twitter (fio – clique para saber mais)

“Immune escape” in #DeltaVariant. That’s the latest finding – that #B16172 is as bad for antibody neutralization as the Beta variant #B1351 from South Africa 🇿🇦. 1st dose alone very small effect— 2 doses needed, but weakest against Delta. Let’s walk through evidence 🧵 #COVID19 https://t.co/GurgkNVgiY pic.twitter.com/o0s9WIudCW

— Eric Feigl-Ding (@DrEricDing) June 5, 2021

 

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Relato de caso: Tratamento bem-sucedido da trombocitopenia imune protrombótica induzida por vacina (VIPIT – vaccine-induced prothrombotic immune thrombocytopenia).

7 Jun, 2021 | 10:28h

Successful treatment of vaccine-induced prothrombotic immune thrombocytopenia (VIPIT) – Journal of Thrombosis and Haemostasis

Comentário: COVID-19 vaccination: Thrombosis can be prevented by prompt treatment, researchers report – Medical University of Vienna

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Estudo de coorte mostrou boa recuperação na maioria das crianças 6 meses após síndrome multissistêmica inflamatória pediátrica (pediatric inflammatory multisystem syndrome – PIMS-TS) associada ao SARS-CoV-2.

3 Jun, 2021 | 10:07h

6-month multidisciplinary follow-up and outcomes of patients with paediatric inflammatory multisystem syndrome (PIMS-TS) at a UK tertiary paediatric hospital: a retrospective cohort study – The Lancet Child & Adolescent Health

Comentário: Most severe effects of MIS-C in children typically resolve within six months, new research suggests – CNN E Children who developed a rare inflammation disease after COVID-19 are mostly better after 6 months, but some still suffer fatigue and anxiety, a small UK study found – Insider E Most severe effects of PIMS-TS resolved at six months – HealthDay

 

Comentário no Twitter

New Research—A study of 46 patients with #PIMSTS found that most symptoms were resolved after 6 months, but fatigue, difficulty exercising, and emotional difficulties persisted in some childrenhttps://t.co/mHz3D8a11d #COVID19 @GreatOrmondSt @KarynMoshal pic.twitter.com/PJCxGGmJNo

— The Lancet Child & Adolescent Health (@LancetChildAdol) May 24, 2021

 

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Lado positivo da pandemia: o vírus da gripe se tornou menos diverso, simplificando a tarefa de produzir vacinas.

3 Jun, 2021 | 10:01h

A pandemic upside: The flu virus became less diverse, simplifying the task of making flu shots – STAT

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Israel relata ligação entre casos raros de inflamação cardíaca e vacinação contra COVID-19 em homens jovens.

2 Jun, 2021 | 10:26h

Israel reports link between rare cases of heart inflammation and COVID-19 vaccination in young men – Science (poucos artigos gratuitos por mês)

Relacionado: CDC is investigating several reports that teenagers and young adults may have developed myocarditis after receiving mRNA vaccines. Most cases were mild, more often in males than females, more often following dose 2 than dose 1, and typically, within 4 days after vaccination.

 

Comentário no Twitter

👇Paging ⁦@CDCgov⁩ and ⁦@US_FDA⁩

“In a report submitted today to the Israeli Ministry of Health, they conclude that between one in 3000 and one in 6000 men ages 16 to 24 who received the vaccine developed the rare condition.” https://t.co/aoz2rkgdwO

— Ramin Farzaneh-Far MD (@rfsquared) June 1, 2021

 

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Após os sucessos com a COVID-19, pesquisadores se esforçam para desenvolver vacinas de mRNA contra outras doenças infecciosas e câncer.

2 Jun, 2021 | 10:24h

After COVID-19 successes, researchers push to develop mRNA vaccines for other diseases – Nature Medicine

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Revisão: Variantes do SARS-CoV-2, mutações na proteína “Spike” e escape imunológico.

2 Jun, 2021 | 10:24h

SARS-CoV-2 variants, spike mutations and immune escape – Nature Reviews Microbiology

 

Comentário no Twitter

A new, exceptional review of the #SARSCoV2 major variants, zooming in on the culprit mutations, Δ epitopes/antigens.
It concludes there is a "high probability of future mutation-mediated escape from host immunity"https://t.co/D4mFot8Ot5@NatureRevMicro @_wharvey @robertson_lab pic.twitter.com/JgzAhpsviq

— Eric Topol (@EricTopol) June 1, 2021

 

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Perspectiva | Posso tomar a vacina da AstraZeneca agora e a da Pfizer depois? Misturar e combinar vacinas contra COVID-19 poderia ajudar a resolver muitos problemas de implementação.

1 Jun, 2021 | 10:28h

Can I get AstraZeneca now and Pfizer later? Why mixing and matching COVID vaccines could help solve many rollout problems – The Conversation

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Vacinas que protegem contra muitos coronavírus poderiam evitar outra pandemia.

1 Jun, 2021 | 10:21h

Vaccines that can protect against many coronaviruses could prevent another pandemic – Science (poucos artigos são gratuitos por mês)

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M-A: Terapia inalatória tripla vs. dupla em pacientes com asma moderada a grave – menos exacerbações com terapia tripla, mas sem diferenças significativas na qualidade de vida ou na mortalidade.

1 Jun, 2021 | 10:19h

Triple vs Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma: A Systematic Review and Meta-analysis – JAMA (gratuito por tempo limitado)

 

Comentário no Twitter

Among patients with moderate to severe asthma, triple therapy compared with dual therapy was significantly associated with fewer severe asthma exacerbations and modest improvements in asthma control but no significant difference in quality of life https://t.co/icKsWu0Md9 #ATS2021

— JAMA (@JAMA_current) May 19, 2021

 

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