Alergia e Imunologia

Breve revisão ACP | Risco de reinfecção após contágio pelo SARS-CoV-2.

25 Jan, 2022 | 15:07h

Risk for Reinfection After SARS-CoV-2: A Living, Rapid Review for American College of Physicians Practice Points on the Role of the Antibody Response in Conferring Immunity Following SARS-CoV-2 Infection – Annals of Internal Medicine

 

Comentário no Twitter

Risk for Reinfection After #SARSCoV2: previous infection reduced risk for reinfection by 87% (95% CI, 84% to 90%). Protection remained above 80% for at least 7 months, but no study followed patients after the emergence of the Delta or #Omicron variant. https://t.co/eruEf1w8Vo

— Prof. Nick Talley (@Prof_NickTalley) January 25, 2022

 

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Estudo de caso-controle | 3 doses de vacinas de mRNA foram associadas com redução nas infecções pelas variantes Ômicron e Delta do SARS-CoV-2 em comparação com 2 doses ou nenhuma vacinação.

25 Jan, 2022 | 12:07h

Association Between 3 Doses of mRNA COVID-19 Vaccine and Symptomatic Infection Caused by the SARS-CoV-2 Omicron and Delta Variants – JAMA

Editorial: Booster Vaccination to Prevent COVID-19 in the Era of Omicron: An Effective Part of a Layered Public Health Approach – JAMA

Comentários: New data show booster doses protect against Omicron – CIDRAP

Boosters provide the best protection against Omicron variant, CDC studies show, raising new questions about what it means to be fully vaccinated – CNN

Estudos do CDC relacionados:

COVID-19 Incidence and Death Rates Among Unvaccinated and Fully Vaccinated Adults with and Without Booster Doses During Periods of Delta and Omicron Variant Emergence — 25 U.S. Jurisdictions, April 4–December 25, 2021 – CDC Morbidity and Mortality Weekly Report

Effectiveness of a Third Dose of mRNA Vaccines Against COVID-19–Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance — VISION Network, 10 States, August 2021–January 2022 – CDC Morbidity and Mortality Weekly Report

 

Comentário no Twitter

Study suggests receipt of 3 doses of mRNA #COVID19 vaccine, vs 2 doses or being unvaccinated, was associated with protection against both the Omicron and Delta variants; higher odds ratios for Omicron suggest less protection for Omicron than for Delta. https://t.co/kOZh0fq5TL

— JAMA (@JAMA_current) January 21, 2022

 

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Guia para imunoterapia na COVID-19.

25 Jan, 2022 | 11:57h

A guide to immunotherapy for COVID-19 – Nature Medicine

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Infecções por SARS-CoV-2 em indivíduos previamente vacinados induz resposta de anticorpos neutralizantes potente, ampla e duradoura.

25 Jan, 2022 | 11:54h

SARS-CoV-2 breakthrough infections elicit potent, broad and durable neutralizing antibody responses – Cell

Comunicado de imprensa: Breakthrough infections spur strong antibody responses – University of Washington School of Medicine

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Estudo randomizado | Em crianças alérgicas a amendoim, imunoterapia oral antes dos 4 anos de idade induziu dessensibilização em 71% dos pacientes e remissão em 21%.

25 Jan, 2022 | 11:47h

Efficacy and safety of oral immunotherapy in children aged 1–3 years with peanut allergy (the Immune Tolerance Network IMPACT trial): a randomised placebo-controlled study – The Lancet (link para o resumo – $ para o texto completo)

Comunicado de imprensa: Oral immunotherapy induces remission of peanut allergy in some young children – NIH News Releases

Comentário: Peanut Oral Immunotherapy at Younger Age Ups Desensitization in Children – HealthDay

 

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Longevidade do reforço: dados revelam quanto tempo dura a proteção da terceira dose.

20 Jan, 2022 | 23:19h

Booster longevity: Data reveals how long a third shot protects – NPR

Relatório original: SARS-CoV-2 variants of concern and variants under investigation in England – U.K. Health Security Agency

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Doença mais leve com a Ômicron: é o vírus ou é a imunidade pré-existente?

20 Jan, 2022 | 23:16h

Milder disease with Omicron: is it the virus or the pre-existing immunity? – Nature Reviews Immunology

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Como a Ômicron se dissemina tão rápido? Uma alta carga viral não é a resposta – “Dados sobre níveis virais apontam para evasão imunológica como causa da transmissibilidade da variante.”

20 Jan, 2022 | 23:15h

How does Omicron spread so fast? A high viral load isn’t the answer – Nature

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Amplo estudo observacional mostrou que pessoas com disfunção imunológica (HIV, transplante de órgão sólido, artrite reumatoide) estão sob risco aumentado de infecção por Covid-19 após a vacinação.

20 Jan, 2022 | 23:11h

Association Between Immune Dysfunction and COVID-19 Breakthrough Infection After SARS-CoV-2 Vaccination in the US – JAMA Internal Medicine

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Estudo traz evidências de causalidade entre vírus Epstein-Barr e esclerose múltipla.

17 Jan, 2022 | 13:05h

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis – Science (link para o resumo – $ para o texto completo)

Comentários:

Strong new evidence suggests a virus triggers multiple sclerosis – STAT

Study identifies Epstein-Barr as a leading candidate for cause of Multiple Sclerosis – Uniformed Services University of the Health Sciences (USU)

Epstein-Barr virus may be leading cause of multiple sclerosis – Harvard T.H. Chan School of Public Health

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