Estudo de coorte | Risco de overdose de opioide é aumentado pelo uso concomitante de oxicodona e inibidores seletivos de recaptação de serotonina que inibem o metabolismo da oxicodona.

Risk of Opioid Overdose Associated With Concomitant Use of Oxycodone and Selective Serotonin Reuptake Inhibitors – JAMA Network Open

Comentário do autor: Taking certain opioids while on commonly prescribed antidepressants may increase the risk of overdose – The Conversation

Comentário no Twitter

This cohort study found that concomitant use of oxycodone with potent CYP2D6-inhibiting serotonin reuptake inhibitors (SSRIs, eg. fluoxetine or paroxetine) is associated with an increased risk of overdose. https://t.co/Eol89RHWAu

— JAMA Network Open (@JAMANetworkOpen) February 24, 2022