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Saúde Pública em Pediatria

Novavax afirma que vacina proteica funciona para crianças a partir dos 12 anos de idade.

14 Fev, 2022 | 16:16h

Novavax says protein vaccine works for kids as young as 12 – Associated Press

Comunicado de imprensa: Novavax Announces Positive Results of COVID-19 Vaccine in Pediatric Population of PREVENT-19 Phase 3 Clinical Trial

Conteúdos relacionados:

Randomized trial with nearly 30.000 individuals showed Novavax vaccine was safe and had an overall efficacy of 90.4% against symptomatic infections.

RCT: Novavax vaccine conferred 89.7% protection against symptomatic SARS-CoV-2 infection and 100% protection against hospitalizations or deaths.

Opinion | The mRNA vaccines are extraordinary, but Novavax is even better.

(Press release – not published yet) Novavax COVID-19 vaccine demonstrates 90% overall efficacy and 100% protection against moderate and severe disease.

RCT: Novavax vaccine is 49.4% effective against B.1.351 SARS-CoV-2 variant.

[Press release – not published yet] Novavax reports 96% efficacy against original strain of COVID-19, 86% efficacy against B.1.1.7 variant, and 55% efficacy against B1.351 variant

New COVID-19 vaccines: here’s how the promising Novavax and Johnson & Johnson jabs work

Covid-19: Novavax vaccine efficacy is 86% against UK variant and 60% against South African variant

Pfizer e FDA recuam em relação ao plano para agilizar a avaliação de vacinas contra Covid-19 em crianças menores de 5 anos.

14 Fev, 2022 | 16:14h

Pfizer and FDA pull back from plan to expedite review of Covid-19 vaccine in young children – STAT

Ver também:

COVID-19 vaccine for kids under 5 delayed as Pfizer extends trial – CIDRAP

Pfizer postpones FDA request for Covid vaccine for kids under 5 – NBC News

Primeira definição para “long Covid” em crianças e jovens é formalmente elaborada.

14 Fev, 2022 | 16:10h

Comunicado de imprensa: First research definition for ‘Long COVID’ in kids and young people formally agreed – BMJ

Artigo original (preprint): Long COVID (Post-COVID-19 condition) in Children: a modified Delphi Process – Archives of Disease in Childhood

Comentários:

Expert reaction to Delphi consensus study on a long-COVID definition in children – Science Media Centre

Long covid: “Holistic” approach is best, given range of symptoms, say researchers – The BMJ

Conteúdos relacionados:

Cohort Study: Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England.

A nationwide cohort study in Denmark showed Long Covid in children is rare and mainly of short duration.

Editorial | Long covid in children and adolescents – “Risk appears low, but many questions remain”.

M-A: Persistent symptoms following SARS-CoV-2 infection among children and young people – “Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms”.

Review: Long COVID symptoms in children rarely persist beyond three months.

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Edição especial | Estratégias baseadas em evidências para melhor prescrição de antibióticos na atenção primária.

14 Fev, 2022 | 16:07h

Editorial: Antibiotic stewardship – Australian Journal of General Practice

Antibiotic stewardship: A review of successful, evidence-based primary care strategies – Australian Journal of General Practice

Evidence-based strategies for better antibiotic prescribing – Australian Journal of General Practice

How can general practitioners reduce antibiotic prescribing in collaboration with their patients? – Australian Journal of General Practice

Bebês nascidos durante o primeiro ano da pandemia tiveram um escore levemente menor em testes de avaliação de desenvolvimento.

11 Fev, 2022 | 14:21h

Comunicado de imprensa: Babies born during pandemic’s first year score slightly lower on a developmental screening test – Columbia University Irving Medical Center

Estudo original: Association of Birth During the COVID-19 Pandemic With Neurodevelopmental Status at 6 Months in Infants With and Without In Utero Exposure to Maternal SARS-CoV-2 Infection – JAMA Pediatrics

Editorial: Understanding the Effects of the Pandemic on Infant Development—The Preterm Problem

Comentários:

Covid-19: Babies born during the pandemic show slight development delays – The BMJ

Pandemic birth tied to poor development – CIDRAP

Estudo de coorte | Saúde mental e física 3 meses depois da infecção por SARS-CoV-2 (“long COVID”) entre adolescentes na Inglaterra.

10 Fev, 2022 | 13:15h

Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England (CLoCk): a national matched cohort study – The Lancet Child & Adolescent Health

Ver também: Long COVID symptoms in SARS-CoV-2-positive adolescents and matched controls (LongCOVIDKidsDK): a national, cross-sectional study – The Lancet Child & Adolescent Health

Editorial: Assessing the impact of the pandemic in children and adolescents: SARS-CoV-2 infection and beyond – The Lancet Child & Adolescent Health

Comentário: Long COVID and kids: more research is urgently needed – Nature

Conteúdos relacionados:

A nationwide cohort study in Denmark showed Long Covid in children is rare and mainly of short duration.

Editorial | Long covid in children and adolescents – “Risk appears low, but many questions remain”.

M-A: Persistent symptoms following SARS-CoV-2 infection among children and young people – “Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms”.

Review: Long COVID symptoms in children rarely persist beyond three months.

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

 

Comentário no Twitter (fio – clique para saber mais)

 

[Preprint] Vigilância ativa de miocardite e pericardite decorrentes da vacinação contra COVID-19 com vacinas do tipo mRNA em pessoas de 12-39 anos na Itália.

10 Fev, 2022 | 13:13h

Post-marketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12-39 years in Italy: a multi-database, self-controlled case series study -medRxiv

Conteúdos relacionados:

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

Comentário no Twitter

 

Apesar de raro, o risco de inflamação cardíaca foi maior em quem recebeu vacina contra Covid da Moderna do que naqueles que receberam a dose da Pfizer.

10 Fev, 2022 | 13:11h

Though rare, Moderna Covid vaccine recipients have higher risk of heart inflammation than Pfizer – CNBC

Conteúdos relacionados:

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Especialistas questionam uma proposta incomum para autorizar vacinação contra Covid em crianças menores de 5 anos.

4 Fev, 2022 | 17:30h

Experts question unusual authorization plan for Covid vaccine for kids under 5 – STAT

Conteúdos relacionados:

Pfizer and BioNTech seeking emergency use authorization from FDA for Covid-19 vaccine for children younger than 5 – CNN

Pfizer asks FDA to allow COVID-19 vaccine for kids under 5 – Associated Press

Pfizer Asks FDA to Approve Its Vaccine for the Youngest Children – HealthDay

M-A | Desfechos do parto de neonatos expostos a maconha in utero.

4 Fev, 2022 | 15:40h

Birth Outcomes of Neonates Exposed to Marijuana in Utero: A Systematic Review and Meta-analysis – JAMA Network Open

Comentário convidado: Reexamining Risks of Prenatal Cannabis Use—Mounting Evidence and a Call to Action – JAMA Network Open

 

Comentário no Twitter

 

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