Infectologia
Revisão | Dose de SARS-CoV-2, infecção e desfechos de doença para COVID-19.
18 Out, 2021 | 08:53hConteúdo relacionado: Seroconversion and fever are dose-dependent in a nonhuman primate model of inhalational COVID-19.
Comentário do autor no Twitter (fio – clique para saber mais)
SARS-CoV-2 Dose, Infection, and Disease Outcomes for COVID-19 – A Review @brosseau_lisa @KevinEscandonMD @AngelaKUlrich @angie_rasmussen Chad Roy @neuronerdsunite @SaskiaPopescu @mtosterholm
https://t.co/2rv0oH1OM5
Quick 🧵 1/ @CIDRAP @acinnacional pic.twitter.com/7lnNYu6eto— Kevin Escandón MD MSc (@KevinEscandonMD) October 15, 2021
[Preprint] Avanço das infecções por SARS-CoV-2 em 620.000 veteranos americanos, de 1/2/2021 a 13/8/2021 – “A proteção da vacina diminuiu de 91,9% em março para 53,9% em meados de agosto.”
18 Out, 2021 | 08:51hConteúdos relacionados:
Editorial | Covid-19 vaccination: evidence of waning immunity is overstated.
COVID vaccine effects wane over time but still prevent death and severe illness.
Perspective | What we actually know about waning immunity.
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
Studies: COVID vaccine protection waning against infection but not hospitalization.
Comentário no Twitter
New on breakthrough infections in 620,000 Veterans
"Vaccine protection declined by mid-August 2021, decreasing from 91.9% in March to 53.9%"https://t.co/xonBb4aEqJ highest reduction with J&J vaccine pic.twitter.com/rbhXOREFPP— Eric Topol (@EricTopol) October 15, 2021
Oito meses depois: pesquisadores comparam as respostas imunes elicitadas por 3 vacinas contra COVID-19.
18 Out, 2021 | 08:50hComunicado de imprensa: Eight months later: Researchers compare immune responses elicited by three COVID-19 vaccines – Beth Israel Deaconess Medical Center
Estudo original: Differential Kinetics of Immune Responses Elicited by Covid-19 Vaccines – New England Journal of Medicine
Comentário no Twitter
Just published @NEJM
Neutralizing antibody levels and T cells response out to 8 months for Pfizer, Moderna and J&J vaccines https://t.co/ghAgk3Y4kR
Moderna highest antibody response; J&J while lower doesn't fall off and best CD8 T-cell response at 8 months pic.twitter.com/uANSzAylMF— Eric Topol (@EricTopol) October 15, 2021
O que as máscaras podem fazer? Parte 2 | O que é preciso para se realizar um bom estudo sobre máscaras – e por que a maioria falha.
18 Out, 2021 | 08:48hCOMMENTARY: What can masks do? Part 2: What makes for a good mask study — and why most fail – CIDRAP
Ver também: COMMENTARY: What can masks do? Part 1: The science behind COVID-19 protection – CIDRAP
Revisão | Tratamento de emergências infecciosas para o dermatologista hospitalar.
18 Out, 2021 | 08:29hManagement of Infectious Emergencies for the Inpatient Dermatologist – Current Dermatology Reports (se este link tiver acesso pago, tente este)
Revisão | Momento da antibioticoterapia na UTI.
18 Out, 2021 | 08:27hTiming of antibiotic therapy in the ICU – Critical Care
Diretriz PHE | O papel das máscaras para atenuar a transmissão do vírus SARS-CoV-2.
15 Out, 2021 | 16:52h
Comentário no Twitter
A good, objective review and a very reasonable choice of words, all things considered: "the evidence suggests that all types of face coverings are, *to some extent*, effective in reducing transmission of SARS-CoV-2 in both HC & public, community settings". https://t.co/7DUD6BxemZ
— Jake Dunning (@OutbreakJake) October 14, 2021
O que as máscaras podem fazer? A ciência por trás da proteção contra COVID-19.
15 Out, 2021 | 16:50hCOMMENTARY: What can masks do? Part 1: The science behind COVID-19 protection – CIDRAP
Estudo avaliou diversos regimes heterólogos de vacinas contra o SARS-CoV-2; não há dados de eficácia, mas houve maior aumento na produção de anticorpos nos participantes 15 e 29 dias depois da dose de reforço com vacinas da Moderna e da Pfizer.
15 Out, 2021 | 16:49hHeterologous SARS-CoV-2 Booster Vaccinations: Preliminary Report – medRxiv
Comentário: Study: Mixing and Matching COVID-19 Booster Shots Is Effective, Safe – U.S. News
Comentário no Twitter
So yes, mRNA vaccines are great at generating antibodies but what does that mean? Where is the efficacy data? How come JnJ gets really great efficacy at preventing symptomatic COVID and severe disease with low antibodies? T-cells? Still much to learn. https://t.co/YwKUyogAhQ
— Daniel Griffin MD PhD (@DanielGriffinMD) October 13, 2021
Em grande estudo populacional, as estatinas estiveram associadas a risco reduzido de morte por COVID-19 – Os pesquisadores apontam que “estudos randomizados serão necessários para verificar se há uma relação causal.”
15 Out, 2021 | 16:48hComunicado de imprensa: Statins linked to reduced risk of death from COVID-19 in major population study – Karolinska Institutet
Estudo original: HMG-CoA reductase inhibitors and COVID-19 mortality in Stockholm, Sweden: A registry-based cohort study – PLOS Medicine
Comentários:
Expert reaction to study looking at statins and risk of death from COVID-19 – Science Media Centre
People taking statins less likely to die from Covid, study suggests – The Guardian