Hematologia

Recomendações do consenso de especialistas sobre o diagnóstico e o tratamento da histiocitose de células de Langerhans em adultos.

17 Mar, 2022 | 12:59h

Expert consensus recommendations for the diagnosis and treatment of Langerhans cell histiocytosis in adults – Blood

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Visão geral da ressuscitação no trauma e complicações de transfusão.

17 Mar, 2022 | 12:39h

Happy TRALIdays: An Overview of Trauma Resuscitation and Transfusion Complications – emDocs

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Diretriz NCCN | Linfomas de células T.

15 Mar, 2022 | 13:10h

T-Cell Lymphomas, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology – Journal of the National Comprehensive Cancer Network

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Metanálise de estudos randomizados comparando estratégias de transfusão de hemácias intraoperatória.

14 Mar, 2022 | 14:07h

A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing Intraoperative Red Blood Cell Transfusion Strategies – Annals of Surgery

Conteúdos relacionados:

Systematic Review: Restrictive transfusion thresholds can safely decrease transfusions by 41% across a broad range of clinical contexts.

RCT: Among patients with acute MI and anemia, a restrictive transfusion strategy resulted in a noninferior rate of major cardiovascular events compared to a liberal transfusion strategy

Randomized trial: Liberal vs. restrictive transfusion thresholds in extremely low-birth-weight infants

Meta-Analysis: Effects of Restrictive vs. Liberal Transfusion Strategies on Longer-term Outcomes After Cardiac Surgery

Randomized Trial: In Patients Undergoing Cardiac Surgery, A Restrictive Transfusion Approach Does Not Increase the Risk of Acute Kidney Injury

Effects of restrictive red blood cell transfusion on the prognoses of adult patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials – Critical Care

Research: Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery

Transfusion Requirements After Cardiac Surgery: The TRACS Randomized Controlled Trial – JAMA

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Metanálise de estudos randomizados | Benefícios e prejuízos de anticoagulantes orais diretos e da heparina de baixo peso molecular para a tromboprofilaxia de pacientes submetidos a cirurgia não cardíaca.

10 Mar, 2022 | 15:52h

Benefits and harms of direct oral anticoagulation and low molecular weight heparin for thromboprophylaxis in patients undergoing non-cardiac surgery: systematic review and network meta-analysis of randomised trials – The BMJ

 

Comentário no Twitter

Led by Maura Marcucci, network meta-analysis of of 68 surgery #RCT's (45,445 patients; mainly #ortho) found that #DOAC's & #LMWH reduce #VTE but probably increase major bleeding to a similar extent. DOACs probably prevent symptomatic VTE more than #LMWH. https://t.co/7vrgVpfD3s pic.twitter.com/H5Fuq7p1hi

— Kari Tikkinen (@KariTikkinen) March 9, 2022

 

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Perspectiva | Uma vez visto como um tratamento promissor da COVID-19, o plasma convalescente cai em desuso.

10 Mar, 2022 | 15:49h

Once Viewed as a Promising COVID-19 Treatment, Convalescent Plasma Falls Out of Favor – JAMA

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Segurança e eficácia do de-escalonamento e descontinuação de antibióticos em pacientes hematológicos de alto risco com neutropenia febril: experiência de centro único.

10 Mar, 2022 | 15:17h

Safety and Efficacy of Antibiotic De-escalation and Discontinuation in High-Risk Hematological Patients With Febrile Neutropenia: A Single-Center Experience – Open Forum Infectious Diseases

Conteúdo relacionado: Management of febrile neutropaenia: ESMO Clinical Practice Guidelines – Annals of Oncology

 

Comentário no Twitter

OFID: In high-risk hematological patients w/ febrile neutropenia, antibiotic de-escalation and discontinuation prior to neutrophil recovery did not lead to an increase in infectious complications. https://t.co/eUer1fmoc6 #IDSAJournals @PaulSaxMD @DrJLi @FungalDoc @jobadd pic.twitter.com/HuGRYA8YW3

— IDSA (@IDSAInfo) January 5, 2022

 

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Estudo randomizado | Em pacientes com choque hemorrágico relacionado a trauma recebendo cuidados pré-hospitalares, não houve benefício na ressuscitação com hemoderivados em comparação com o cloreto de sódio 0,9%.

9 Mar, 2022 | 13:49h

Resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care (RePHILL): a multicentre, open-label, randomised, controlled, phase 3 trial – The Lancet Haematology

Comentário convidado: Prehospital blood transfusion: who benefits? – The Lancet Haematology

 

Comentário no Twitter

NEW research—resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care: results of #RePHILL, a randomised, controlled, phase 3 trial #openaccess #EmergencyMedicine 🚑🩸https://t.co/Ci0lMMCryX pic.twitter.com/iWEtV12N1r

— The Lancet Haematology (@TheLancetHaem) March 8, 2022

 

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Revisão | Cardiotoxicidade da terapia com antígeno quimérico receptor de célula T para malignidades avançadas.

9 Mar, 2022 | 13:28h

Cardiotoxicity from chimeric antigen receptor-T cell therapy for advanced malignancies – European Heart Journal

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Revisão sistemática | Anticoagulantes para pessoas internadas com COVID-19.

8 Mar, 2022 | 17:53h

Anticoagulants for people hospitalised with COVID‐19 – Cochrane Library

Resumo: Do blood thinners prevent people who are hospitalised with COVID-19 from developing blood clots? – Cochrane Library

Conteúdo relacionado: Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week.

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