Hematologia
Primeiro caso de cura do HIV em uma mulher após transplante de célula tronco relatado no CROI-2022.
29 Mar, 2022 | 13:57hEstudo de coorte | Tratamento de longo prazo com clozapina está associado com risco aumentado de malignidades hematológicas.
29 Mar, 2022 | 13:56hLong-term treatment with clozapine and other antipsychotic drugs and the risk of haematological malignancies in people with schizophrenia: a nationwide case-control and cohort study in Finland – The Lancet Psychiatry (link para o resumo – $ para o texto completo)
Comentário no Twitter
Clozapine associated with an increased risk of haematological malignancies with a dose-response effect.
More deaths than from agranulocytosis, but absolute risk small compared to overall mortality benefit with clozapine.https://t.co/BK3P7GgPiv@TheLancetPsych
— Jonathan Rogers (@drjprogers) March 24, 2022
Estudo randomizado | Entre pacientes críticos com Covid-19, o tratamento com um agente antiplaquetário teve pouca propensão a melhorar os dias sem suporte de órgão em 21 dias.
24 Mar, 2022 | 12:33hEditorial: Thromboinflammation and Antithrombotics in COVID-19: Accumulating Evidence and Current Status – JAMA
Comentário: Aspirin may improve 3-month survival for patients critically ill with COVID-19 – Imperial College London
Comentários no Twitter
In this bayesian randomized clinical trial, among critically ill patients with #COVID19, there was a low likelihood that treatment with an antiplatelet agent provided improvement in organ support–free days within 21 days. https://t.co/CnyWoOTn3Q
— JAMA (@JAMA_current) March 22, 2022
Diretrizes sobre doença falciforme | Prevenção secundária de AVC em crianças e adolescentes.
23 Mar, 2022 | 11:47hConteúdo relacionado: RCT: In children with sickle cell anemia, hydroxyurea in moderate doses (20 mg/kg per day) is not better than low doses (10 mg/kg per day) for primary stroke prevention.
Debate Pró-Con | Transfusão sanguínea pré-hospitalar – deveria ser adotada para traumas em civis?
22 Mar, 2022 | 11:37hInfográfico: Pre-Hospital Blood Transfusion: A Pro-Con Debate – Anesthesia & Analgesia
Conteúdo relacionado: RCT: In patients with trauma-related hemorrhagic shock receiving prehospital care, there was no benefit from resuscitation with blood products compared to 0.9% sodium chloride.
Terapia genética com valoctocogene roxaparvovec para hemofilia A.
22 Mar, 2022 | 11:28hValoctocogene Roxaparvovec Gene Therapy for Hemophilia A – New England Journal of Medicine (link para o resumo – $ para o texto completo)
Comentários:
Valoctocogene Roxaparvovec Evaluated in Severe Hemophilia A – HealthDay
Hemophilia A Gene Therapy Reduced Bleeding Events, Need for Clotting Factors – AJMC
Estudo randomizado de fase 2 | Consolidação com venetoclax após duração fixa de venetoclax com obinutuzumabe para leucemia linfocítica crônica sem tratamento prévio.
22 Mar, 2022 | 11:23hVenetoclax consolidation after fixed-duration venetoclax plus obinutuzumab for previously untreated chronic lymphocytic leukaemia (HOVON 139/GiVe): primary endpoint analysis of a multicentre, open-label, randomised, parallel-group, phase 2 trial – The Lancet Haematology (link para o resumo – $ para o texto completo)
Comentário no Twitter
NEW: Results from the HOVON 139/GiVe, ph 2 trial show that consolidation with venetoclax after fixed-duration venetoclax + obinutuzumab in patients w/ previously untreated CLL increases known side-effects & does not prevent MRD and risk of relapse #lymsm https://t.co/VzCUSHPMrp pic.twitter.com/PB62XNLAIK
— The Lancet Haematology (@TheLancetHaem) March 2, 2022
Diretriz | Manejo de anticoagulantes e antiplaquetários durante sangramento gastrintestinal agudo e período periendoscópico.
21 Mar, 2022 | 16:38h
Comentário no Twitter
BREAKING 🔥
Antiplatelets, anticoagulants and #EndoscopyNew CPG & dissemination tool.
An @AmCollegeGastro @CanGastroAssn co-production @AmJGastro and #JCAG@GriLeont @BryanGSauer @NeenaSAbrahamMD @alan_barkun @ThrombosisCan @LorenLaine2 #JenTelfordhttps://t.co/Ijs4jgOkPC pic.twitter.com/uUfN2zj3RS
— Journal of the Canadian Assn of Gastroenterology (@JCanAssnGastro) March 17, 2022
Estudo randomizado | Eficácia de plinabulina vs. pegfilgrastima para prevenir neutropenia induzida por docetaxel em pacientes com tumores de órgãos sólidos.
21 Mar, 2022 | 16:01h
Comentário no Twitter
This RCT found that same-day plinabulin, a novel selective immunomodulating microtubule binding agent (SIMBA), is noninferior to next-day pegfilgrastim in chemotherapy-induced neutropenia prevention in patients receiving docetaxel chemotherapy. https://t.co/tUXuffISmB pic.twitter.com/LROsd3trPv
— JAMA Network Open (@JAMANetworkOpen) January 27, 2022
Estudo randomizado | Bortezomibe em leucemia linfoblástica aguda e linfoma de células T recém-diagnosticados.
21 Mar, 2022 | 15:56hChildren’s Oncology Group Trial AALL1231: A Phase III Clinical Trial Testing Bortezomib in Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia and Lymphoma – Journal of Clinical Oncology (link para o resumo – $ para o texto completo)