Estudos Randomizados

Estudo randomizado | Pequeno estudo sugere que a ablação híbrida é mais efetiva do que a ablação por cateter repetida na fibrilação atrial persistente

23 Jan, 2023 | 13:15h

Hybrid Ablation Versus Repeated Catheter Ablation in Persistent Atrial Fibrillation: A Randomized Controlled Trial – JACC: Clinical Electrophysiology

Comentário: Hybrid Versus Catheter Ablation in Persistent Atrial Fibrillation – HARTCAP-AF – American College of Cardiology

 

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Estudo randomizado | Fluvoxamina não é melhor que placebo em pacientes ambulatoriais com COVID-19 leve a moderada

16 Jan, 2023 | 11:12h

Effect of Fluvoxamine vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial – JAMA

Editorial: Lack of Benefit of Fluvoxamine for COVID-19 – JAMA

Entrevista com a autora: Fluvoxamine vs Placebo and Time to Sustained Recovery From Mild or Moderate COVID-19 – JAMA

Comentário: Trial finds that fluvoxamine doesn’t speed COVID recovery – CIDRAP

 

Comentário no Twitter

Among outpatients with mild to moderate #COVID19, treatment with 50 mg of fluvoxamine twice daily for 10 days, compared with placebo, did not improve time to sustained recovery. https://t.co/4QgBssqFSU pic.twitter.com/RMZ6mqlx6u

— JAMA (@JAMA_current) January 12, 2023

 

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Estudo randomizado | Ecopipam para síndrome de Tourette

16 Jan, 2023 | 10:49h

Ecopipam for Tourette Syndrome: A Randomized Trial – Pediatrics

Comentário: Ecopipam May Reduce Tics in Children With Tourette Syndrome – Psychiatric News Alert

 

Comentário no Twitter

Ecopipam, a selective D1-like receptor antagonist, is in development for children & adolescents with Tourette syndrome. Can ecopipam achieve a clinically meaningful reduction in tics without the disadvantages of D2-like receptor antagonists? https://t.co/GXxnPsP74C #Pediatrics pic.twitter.com/14fwu4npJi

— AAP Pediatrics (@aap_peds) January 11, 2023

 

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Estudo randomizado | Lebriquizumabe combinado com corticosteroides tópicos em adolescentes e adultos com dermatite atópica moderada a grave

16 Jan, 2023 | 10:48h

Efficacy and Safety of Lebrikizumab in Combination With Topical Corticosteroids in Adolescents and Adults With Moderate-to-Severe Atopic Dermatitis: A Randomized Clinical Trial (ADhere) – JAMA Dermatology

 

Comentário no Twitter

Does blocking the IL-13 cytokine w/ lebrikizumab combined w/ topical therapy provide clinical benefit in atopic eczema? This study reflecting real-world use patterns suggests a benefit. https://t.co/apUvYO3Jqv

— JAMA Dermatology (@JAMADerm) January 13, 2023

 

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Estudo randomizado | Radioterapia corpórea estereotáxica guiada por RM vs. guiada por TC para câncer de próstata

16 Jan, 2023 | 10:47h

Magnetic Resonance Imaging–Guided vs Computed Tomography–Guided Stereotactic Body Radiotherapy for Prostate Cancer: The MIRAGE Randomized Clinical Trial – JAMA Oncology

Comunicado de imprensa: MRI-guided radiotherapy produces fewer side effects and better quality of life for patients with localized prostate cancer – University of California

 

Comentário do autor no Twitter (fio – clique para saber mais)

Pleased to share the primary endpoint results of the randomized phase III MIRAGE trial evaluating whether aggressive margin reduction with MRI-guidance leads to reduced toxicity in the context of prostate SBRT, out today in @JAMAOncology https://t.co/5ZKElUR4uk (1/n)

— Amar Kishan (@AmarUKishan) January 12, 2023

 

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Estudo randomizado | Em pacientes submetidos a cirurgia cardíaca, alta dose de selênio intravenoso não reduziu a morbidade ou a mortalidade

16 Jan, 2023 | 10:43h

Effect of High-Dose Selenium on Postoperative Organ Dysfunction and Mortality in Cardiac Surgery Patients: The SUSTAIN CSX Randomized Clinical Trial – JAMA Surgery

 

Comentário no Twitter

In this study, high-dose sodium selenite was not effective in reducing the development of organ dysfunction and death in high-risk cardiac surgery patients. @CStoppe @CriticalCa https://t.co/H3HR1u1HhU

— JAMA Surgery (@JAMASurgery) January 12, 2023

 

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Estudo randomizado transversal | Estudo preliminar mostrou que a entrega de insulina em circuito fechado pode melhorar o controle glicêmico em alguns adultos com DM tipo 2

16 Jan, 2023 | 10:40h

Fully automated closed-loop insulin delivery in adults with type 2 diabetes: an open-label, single-center, randomized crossover trial – Nature Medicine

Comunicado de imprensa: Artificial pancreas successfully trialed for use by type 2 diabetes patients – University of Cambridge

Comentário: Artificial Pancreas Device May Help Folks With Type 2 Diabetes – HealthDay

 

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Estudo randomizado | Resultados cosméticos e efeitos adversos da irradiação acelerada parcial da mama vs. irradiação completa da mama para carcinoma mamário invasivo de baixo risco

16 Jan, 2023 | 10:39h

Cosmetic Results and Side Effects of Accelerated Partial-Breast Irradiation Versus Whole-Breast Irradiation for Low-Risk Invasive Carcinoma of the Breast: The Randomized Phase III IRMA Trial – Journal of Clinical Oncology (link para o resumo – $ para o texto completo)

 

Comentário do autor no Twitter

5yr results of the phase 3 #IRMAtrial: EBRT #APBI b.i.d. associated with slightly increased rate of moderate soft tissue and bone toxicity and a slightly inferior cosmesis, though overall toxicity was in an acceptable range @JCO_ASCO #BCSM @OncoAlert https://t.co/8LHE2ut3t2

— Bruno Meduri (@brunomeduri) January 9, 2023

 

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Estudo randomizado | Radioterapia torácica de alta dose 1 vez/dia em câncer de pulmão de pequenas células em estágio limitado

16 Jan, 2023 | 10:37h

High-Dose Once-Daily Thoracic Radiotherapy in Limited-Stage Small-Cell Lung Cancer: CALGB 30610 (Alliance)/RTOG 0538 – Journal of Clinical Oncology (link para o resumo – $ para o texto completo)

 

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Estudo randomizado | Uso de zinco por via oral 2 vezes/dia no tratamento de pacientes com COVID-19.

13 Dez, 2022 | 15:16h

Twice-Daily Oral Zinc in the Treatment of Patients With Coronavirus Disease 2019: A Randomized Double-Blind Controlled Trial – Clinical Infectious Diseases

 

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